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Gene: CTDSPL |
Gene summary for CTDSPL |
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Gene information | Species | Human | Gene symbol | CTDSPL | Gene ID | 10217 |
Gene name | CTD small phosphatase like | |
Gene Alias | C3orf8 | |
Cytomap | 3p22.2 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | O15194 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10217 | CTDSPL | CA_HPV_3 | Human | Cervix | CC | 5.93e-05 | 1.67e-01 | 0.0414 |
10217 | CTDSPL | CCI_2 | Human | Cervix | CC | 9.93e-05 | 7.93e-01 | 0.5249 |
10217 | CTDSPL | HTA11_347_2000001011 | Human | Colorectum | AD | 7.57e-12 | 6.53e-01 | -0.1954 |
10217 | CTDSPL | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.92e-11 | 9.03e-01 | 0.0131 |
10217 | CTDSPL | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.40e-03 | 6.63e-01 | -0.0124 |
10217 | CTDSPL | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.15e-06 | 1.06e+00 | 0.3487 |
10217 | CTDSPL | F007 | Human | Colorectum | FAP | 1.11e-08 | -5.51e-01 | 0.1176 |
10217 | CTDSPL | A001-C-207 | Human | Colorectum | FAP | 5.78e-04 | -3.69e-01 | 0.1278 |
10217 | CTDSPL | A015-C-203 | Human | Colorectum | FAP | 1.90e-24 | -5.20e-01 | -0.1294 |
10217 | CTDSPL | A015-C-204 | Human | Colorectum | FAP | 4.08e-07 | -4.46e-01 | -0.0228 |
10217 | CTDSPL | A014-C-040 | Human | Colorectum | FAP | 1.57e-05 | -6.08e-01 | -0.1184 |
10217 | CTDSPL | A002-C-201 | Human | Colorectum | FAP | 7.41e-17 | -5.22e-01 | 0.0324 |
10217 | CTDSPL | A002-C-203 | Human | Colorectum | FAP | 9.80e-03 | -2.32e-01 | 0.2786 |
10217 | CTDSPL | A001-C-119 | Human | Colorectum | FAP | 3.04e-10 | -6.42e-01 | -0.1557 |
10217 | CTDSPL | A001-C-108 | Human | Colorectum | FAP | 6.46e-20 | -5.36e-01 | -0.0272 |
10217 | CTDSPL | A002-C-205 | Human | Colorectum | FAP | 3.49e-29 | -7.11e-01 | -0.1236 |
10217 | CTDSPL | A001-C-104 | Human | Colorectum | FAP | 1.36e-05 | -3.73e-01 | 0.0184 |
10217 | CTDSPL | A015-C-005 | Human | Colorectum | FAP | 6.54e-03 | -2.86e-01 | -0.0336 |
10217 | CTDSPL | A015-C-006 | Human | Colorectum | FAP | 9.56e-19 | -6.40e-01 | -0.0994 |
10217 | CTDSPL | A015-C-106 | Human | Colorectum | FAP | 1.41e-12 | -3.37e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000717810 | Esophagus | ESCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 195/8552 | 355/18723 | 2.58e-04 | 1.58e-03 | 195 |
GO:004682713 | Esophagus | ESCC | positive regulation of protein export from nucleus | 14/8552 | 17/18723 | 2.22e-03 | 9.78e-03 | 14 |
GO:00423267 | Liver | NAFLD | negative regulation of phosphorylation | 67/1882 | 385/18723 | 5.49e-06 | 1.98e-04 | 67 |
GO:00512227 | Liver | NAFLD | positive regulation of protein transport | 55/1882 | 303/18723 | 1.07e-05 | 3.35e-04 | 55 |
GO:00459367 | Liver | NAFLD | negative regulation of phosphate metabolic process | 73/1882 | 441/18723 | 1.31e-05 | 3.93e-04 | 73 |
GO:00105637 | Liver | NAFLD | negative regulation of phosphorus metabolic process | 73/1882 | 442/18723 | 1.42e-05 | 4.17e-04 | 73 |
GO:00163115 | Liver | NAFLD | dephosphorylation | 69/1882 | 417/18723 | 2.27e-05 | 6.23e-04 | 69 |
GO:00064706 | Liver | NAFLD | protein dephosphorylation | 50/1882 | 281/18723 | 4.53e-05 | 1.09e-03 | 50 |
GO:19049517 | Liver | NAFLD | positive regulation of establishment of protein localization | 55/1882 | 319/18723 | 4.79e-05 | 1.14e-03 | 55 |
GO:0044772 | Liver | NAFLD | mitotic cell cycle phase transition | 67/1882 | 424/18723 | 1.25e-04 | 2.39e-03 | 67 |
GO:00069137 | Liver | NAFLD | nucleocytoplasmic transport | 51/1882 | 301/18723 | 1.39e-04 | 2.62e-03 | 51 |
GO:00511697 | Liver | NAFLD | nuclear transport | 51/1882 | 301/18723 | 1.39e-04 | 2.62e-03 | 51 |
GO:0044843 | Liver | NAFLD | cell cycle G1/S phase transition | 43/1882 | 241/18723 | 1.40e-04 | 2.63e-03 | 43 |
GO:0000082 | Liver | NAFLD | G1/S transition of mitotic cell cycle | 39/1882 | 214/18723 | 1.78e-04 | 3.14e-03 | 39 |
GO:00071784 | Liver | NAFLD | transmembrane receptor protein serine/threonine kinase signaling pathway | 56/1882 | 355/18723 | 4.50e-04 | 6.62e-03 | 56 |
GO:00903166 | Liver | NAFLD | positive regulation of intracellular protein transport | 29/1882 | 160/18723 | 1.24e-03 | 1.41e-02 | 29 |
GO:00511687 | Liver | NAFLD | nuclear export | 28/1882 | 154/18723 | 1.42e-03 | 1.58e-02 | 28 |
GO:00019337 | Liver | NAFLD | negative regulation of protein phosphorylation | 52/1882 | 342/18723 | 1.63e-03 | 1.74e-02 | 52 |
GO:00468227 | Liver | NAFLD | regulation of nucleocytoplasmic transport | 21/1882 | 106/18723 | 1.81e-03 | 1.86e-02 | 21 |
GO:00331576 | Liver | NAFLD | regulation of intracellular protein transport | 37/1882 | 229/18723 | 2.55e-03 | 2.36e-02 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTDSPL | SNV | Missense_Mutation | novel | c.154G>A | p.Asp52Asn | p.D52N | O15194 | protein_coding | tolerated(0.55) | benign(0) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
CTDSPL | SNV | Missense_Mutation | c.292N>A | p.Glu98Lys | p.E98K | O15194 | protein_coding | tolerated(0.17) | benign(0.139) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
CTDSPL | SNV | Missense_Mutation | novel | c.385N>C | p.Asp129His | p.D129H | O15194 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
CTDSPL | SNV | Missense_Mutation | c.166G>C | p.Glu56Gln | p.E56Q | O15194 | protein_coding | tolerated(0.2) | benign(0.043) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CTDSPL | SNV | Missense_Mutation | c.415N>G | p.Thr139Ala | p.T139A | O15194 | protein_coding | deleterious(0.03) | benign(0.097) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CTDSPL | SNV | Missense_Mutation | novel | c.226N>T | p.Leu76Phe | p.L76F | O15194 | protein_coding | tolerated(0.16) | benign(0.001) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CTDSPL | SNV | Missense_Mutation | c.485N>G | p.Phe162Cys | p.F162C | O15194 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CTDSPL | SNV | Missense_Mutation | rs370003443 | c.551N>A | p.Arg184His | p.R184H | O15194 | protein_coding | deleterious(0.03) | possibly_damaging(0.571) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CTDSPL | SNV | Missense_Mutation | rs567415488 | c.94N>A | p.Val32Ile | p.V32I | O15194 | protein_coding | tolerated(0.3) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CTDSPL | SNV | Missense_Mutation | rs747525595 | c.152G>A | p.Arg51His | p.R51H | O15194 | protein_coding | tolerated(0.11) | benign(0.02) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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