Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CIT

Gene summary for CIT

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CIT

Gene ID

11113

Gene namecitron rho-interacting serine/threonine kinase
Gene AliasCITK
Cytomap12q24.23
Gene Typeprotein-coding
GO ID

GO:0000278

UniProtAcc

O14578


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11113CITTD9HumanLungIAC1.02e-025.71e-010.088
11113CITRNA-P6T1-P6T1-1HumanLungMIAC6.67e-049.05e-01-0.0238
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00017015LiverCirrhoticin utero embryonic development134/4634367/187232.78e-076.86e-06134
GO:004873212LiverCirrhoticgland development154/4634436/187234.03e-079.42e-06154
GO:00704827LiverCirrhoticresponse to oxygen levels125/4634347/187231.55e-063.02e-05125
GO:003009912LiverCirrhoticmyeloid cell differentiation135/4634381/187231.69e-063.22e-05135
GO:007155911LiverCirrhoticresponse to transforming growth factor beta96/4634256/187233.55e-066.09e-0596
GO:007156011LiverCirrhoticcellular response to transforming growth factor beta stimulus93/4634250/187237.34e-061.13e-0493
GO:003410112LiverCirrhoticerythrocyte homeostasis54/4634129/187231.41e-051.97e-0454
GO:00362937LiverCirrhoticresponse to decreased oxygen levels113/4634322/187231.87e-052.52e-04113
GO:00016667LiverCirrhoticresponse to hypoxia108/4634307/187232.51e-053.26e-04108
GO:000756812LiverCirrhoticaging117/4634339/187233.13e-053.91e-04117
GO:00302187LiverCirrhoticerythrocyte differentiation50/4634120/187233.35e-054.13e-0450
GO:00018905LiverCirrhoticplacenta development57/4634144/187235.74e-056.58e-0457
GO:00714536LiverCirrhoticcellular response to oxygen levels67/4634177/187237.10e-057.98e-0467
GO:004361812LiverCirrhoticregulation of transcription from RNA polymerase II promoter in response to stress24/463447/187239.00e-059.67e-0424
GO:004362012LiverCirrhoticregulation of DNA-templated transcription in response to stress26/463453/187231.11e-041.12e-0326
GO:00457857LiverCirrhoticpositive regulation of cell adhesion141/4634437/187232.05e-041.89e-03141
GO:000226212LiverCirrhoticmyeloid cell homeostasis59/4634157/187232.33e-042.11e-0359
GO:000717911LiverCirrhotictransforming growth factor beta receptor signaling pathway71/4634198/187233.02e-042.65e-0371
GO:00714563LiverCirrhoticcellular response to hypoxia56/4634151/187234.86e-043.90e-0356
GO:00362946LiverCirrhoticcellular response to decreased oxygen levels59/4634161/187234.98e-043.98e-0359
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CITSNVMissense_Mutationrs779515686c.4130N>Tp.Pro1377Leup.P1377LO14578protein_codingdeleterious(0)benign(0.248)TCGA-A2-A0EW-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinPD
CITSNVMissense_Mutationc.5132C>Tp.Ser1711Phep.S1711FO14578protein_codingdeleterious(0)probably_damaging(0.972)TCGA-A2-A0SV-01Breastbreast invasive carcinomaFemale<65III/IVOther, specify in notesBisphosphonate therapyzometaPD
CITSNVMissense_Mutationnovelc.2482N>Ap.Glu828Lysp.E828KO14578protein_codingdeleterious(0.04)possibly_damaging(0.628)TCGA-A2-A25C-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereSD
CITSNVMissense_Mutationc.3097G>Tp.Val1033Leup.V1033LO14578protein_codingtolerated(0.08)probably_damaging(0.978)TCGA-A8-A076-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
CITSNVMissense_Mutationrs747447396c.2839C>Tp.Arg947Cysp.R947CO14578protein_codingdeleterious(0.02)possibly_damaging(0.446)TCGA-A8-A09X-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
CITSNVMissense_Mutationrs747447396c.2839N>Tp.Arg947Cysp.R947CO14578protein_codingdeleterious(0.02)possibly_damaging(0.446)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
CITSNVMissense_Mutationc.242N>Tp.Ser81Phep.S81FO14578protein_codingdeleterious(0.02)benign(0.17)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
CITSNVMissense_Mutationnovelc.637N>Tp.His213Tyrp.H213YO14578protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AC-A5XS-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyfemaraSD
CITSNVMissense_Mutationrs368981957c.5590N>Ap.Asp1864Asnp.D1864NO14578protein_codingdeleterious(0)probably_damaging(0.964)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CITSNVMissense_Mutationnovelc.1771N>Ap.Glu591Lysp.E591KO14578protein_codingtolerated(0.31)benign(0.019)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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