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Gene: CD151 |
Gene summary for CD151 |
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Gene information | Species | Human | Gene symbol | CD151 | Gene ID | 977 |
Gene name | CD151 molecule (Raph blood group) | |
Gene Alias | GP27 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A0A024RCB3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
977 | CD151 | GSM4909285 | Human | Breast | IDC | 1.96e-14 | -4.54e-01 | 0.21 |
977 | CD151 | GSM4909286 | Human | Breast | IDC | 5.12e-04 | -2.71e-01 | 0.1081 |
977 | CD151 | GSM4909294 | Human | Breast | IDC | 1.91e-03 | -2.98e-01 | 0.2022 |
977 | CD151 | GSM4909296 | Human | Breast | IDC | 1.42e-06 | -3.07e-02 | 0.1524 |
977 | CD151 | GSM4909297 | Human | Breast | IDC | 1.21e-14 | -1.85e-01 | 0.1517 |
977 | CD151 | GSM4909301 | Human | Breast | IDC | 1.70e-03 | -3.19e-01 | 0.1577 |
977 | CD151 | GSM4909305 | Human | Breast | IDC | 2.24e-03 | 2.66e-01 | 0.0436 |
977 | CD151 | GSM4909311 | Human | Breast | IDC | 2.21e-31 | -3.30e-01 | 0.1534 |
977 | CD151 | GSM4909312 | Human | Breast | IDC | 1.22e-15 | -4.60e-01 | 0.1552 |
977 | CD151 | GSM4909316 | Human | Breast | IDC | 9.20e-04 | 1.15e-02 | 0.21 |
977 | CD151 | GSM4909317 | Human | Breast | IDC | 7.71e-19 | 5.06e-01 | 0.1355 |
977 | CD151 | GSM4909319 | Human | Breast | IDC | 3.32e-39 | -1.47e-01 | 0.1563 |
977 | CD151 | GSM4909320 | Human | Breast | IDC | 1.73e-05 | -3.07e-01 | 0.1575 |
977 | CD151 | GSM4909321 | Human | Breast | IDC | 1.28e-13 | -1.26e-02 | 0.1559 |
977 | CD151 | brca1 | Human | Breast | Precancer | 3.30e-31 | 5.99e-01 | -0.0338 |
977 | CD151 | brca2 | Human | Breast | Precancer | 2.06e-22 | 4.75e-01 | -0.024 |
977 | CD151 | brca3 | Human | Breast | Precancer | 1.13e-17 | 4.73e-01 | -0.0263 |
977 | CD151 | brca10 | Human | Breast | Precancer | 1.94e-02 | 2.22e-01 | -0.0029 |
977 | CD151 | NCCBC14 | Human | Breast | DCIS | 2.57e-20 | -2.80e-01 | 0.2021 |
977 | CD151 | NCCBC2 | Human | Breast | DCIS | 3.91e-03 | -1.04e-01 | 0.1554 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00706618 | Oral cavity | OSCC | leukocyte proliferation | 145/7305 | 318/18723 | 9.31e-03 | 3.33e-02 | 145 |
GO:00466517 | Oral cavity | OSCC | lymphocyte proliferation | 131/7305 | 288/18723 | 1.41e-02 | 4.67e-02 | 131 |
GO:003010017 | Oral cavity | LP | regulation of endocytosis | 81/4623 | 211/18723 | 6.57e-06 | 1.29e-04 | 81 |
GO:0042060110 | Oral cavity | LP | wound healing | 139/4623 | 422/18723 | 7.10e-05 | 9.48e-04 | 139 |
GO:004211017 | Oral cavity | LP | T cell activation | 146/4623 | 487/18723 | 4.13e-03 | 2.66e-02 | 146 |
GO:004580717 | Oral cavity | LP | positive regulation of endocytosis | 36/4623 | 100/18723 | 7.54e-03 | 4.16e-02 | 36 |
GO:004206018 | Prostate | BPH | wound healing | 123/3107 | 422/18723 | 5.74e-11 | 3.59e-09 | 123 |
GO:00443195 | Prostate | BPH | wound healing, spreading of cells | 19/3107 | 34/18723 | 2.09e-07 | 4.59e-06 | 19 |
GO:00905055 | Prostate | BPH | epiboly involved in wound healing | 19/3107 | 34/18723 | 2.09e-07 | 4.59e-06 | 19 |
GO:00905045 | Prostate | BPH | epiboly | 19/3107 | 35/18723 | 3.86e-07 | 8.02e-06 | 19 |
GO:00020113 | Prostate | BPH | morphogenesis of an epithelial sheet | 25/3107 | 57/18723 | 1.19e-06 | 2.10e-05 | 25 |
GO:003010010 | Prostate | BPH | regulation of endocytosis | 60/3107 | 211/18723 | 1.06e-05 | 1.45e-04 | 60 |
GO:00458079 | Prostate | BPH | positive regulation of endocytosis | 32/3107 | 100/18723 | 1.09e-04 | 9.95e-04 | 32 |
GO:004211010 | Prostate | BPH | T cell activation | 111/3107 | 487/18723 | 2.11e-04 | 1.72e-03 | 111 |
GO:004209810 | Prostate | BPH | T cell proliferation | 46/3107 | 199/18723 | 1.05e-02 | 4.39e-02 | 46 |
GO:004206019 | Prostate | Tumor | wound healing | 127/3246 | 422/18723 | 5.32e-11 | 3.41e-09 | 127 |
GO:004431912 | Prostate | Tumor | wound healing, spreading of cells | 17/3246 | 34/18723 | 1.28e-05 | 1.78e-04 | 17 |
GO:009050512 | Prostate | Tumor | epiboly involved in wound healing | 17/3246 | 34/18723 | 1.28e-05 | 1.78e-04 | 17 |
GO:009050412 | Prostate | Tumor | epiboly | 17/3246 | 35/18723 | 2.09e-05 | 2.71e-04 | 17 |
GO:000201112 | Prostate | Tumor | morphogenesis of an epithelial sheet | 23/3246 | 57/18723 | 3.51e-05 | 4.11e-04 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CD151 | SNV | Missense_Mutation | c.645C>A | p.Phe215Leu | p.F215L | P48509 | protein_coding | deleterious(0.05) | possibly_damaging(0.837) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CD151 | deletion | Frame_Shift_Del | novel | c.369delN | p.Glu124ArgfsTer3 | p.E124Rfs*3 | P48509 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CD151 | SNV | Missense_Mutation | c.188N>G | p.Ile63Ser | p.I63S | P48509 | protein_coding | deleterious(0.04) | possibly_damaging(0.643) | TCGA-FU-A3TX-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CD151 | SNV | Missense_Mutation | rs534240443 | c.619G>A | p.Gly207Ser | p.G207S | P48509 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CD151 | SNV | Missense_Mutation | c.641N>T | p.Thr214Ile | p.T214I | P48509 | protein_coding | deleterious(0.04) | benign(0.062) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CD151 | deletion | Frame_Shift_Del | c.533delN | p.Arg178LeufsTer43 | p.R178Lfs*43 | P48509 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
CD151 | SNV | Missense_Mutation | novel | c.209N>C | p.Val70Ala | p.V70A | P48509 | protein_coding | deleterious(0) | possibly_damaging(0.489) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CD151 | SNV | Missense_Mutation | rs758951148 | c.272N>A | p.Arg91His | p.R91H | P48509 | protein_coding | tolerated(0.56) | possibly_damaging(0.806) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CD151 | SNV | Missense_Mutation | novel | c.364N>T | p.Leu122Phe | p.L122F | P48509 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CD151 | SNV | Missense_Mutation | rs766766478 | c.337N>A | p.Ala113Thr | p.A113T | P48509 | protein_coding | deleterious(0) | benign(0.017) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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