Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CCT7_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CCT7_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CCT7_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CCT7_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CCT7_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CCT7_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CCT7_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CCT7_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CCT7_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00322042 | Colorectum | MSS | regulation of telomere maintenance | 29/3467 | 80/18723 | 1.35e-04 | 2.04e-03 | 29 |
GO:00330441 | Colorectum | MSS | regulation of chromosome organization | 55/3467 | 187/18723 | 1.86e-04 | 2.63e-03 | 55 |
GO:00322062 | Colorectum | MSS | positive regulation of telomere maintenance | 21/3467 | 52/18723 | 1.98e-04 | 2.78e-03 | 21 |
GO:00108332 | Colorectum | MSS | telomere maintenance via telomere lengthening | 28/3467 | 81/18723 | 4.34e-04 | 5.23e-03 | 28 |
GO:19043582 | Colorectum | MSS | positive regulation of telomere maintenance via telomere lengthening | 16/3467 | 37/18723 | 4.51e-04 | 5.38e-03 | 16 |
GO:00322122 | Colorectum | MSS | positive regulation of telomere maintenance via telomerase | 15/3467 | 34/18723 | 5.22e-04 | 5.99e-03 | 15 |
GO:00007232 | Colorectum | MSS | telomere maintenance | 40/3467 | 131/18723 | 5.86e-04 | 6.49e-03 | 40 |
GO:19043562 | Colorectum | MSS | regulation of telomere maintenance via telomere lengthening | 22/3467 | 61/18723 | 9.05e-04 | 9.21e-03 | 22 |
GO:00070041 | Colorectum | MSS | telomere maintenance via telomerase | 24/3467 | 69/18723 | 9.79e-04 | 9.84e-03 | 24 |
GO:00718972 | Colorectum | MSS | DNA biosynthetic process | 50/3467 | 180/18723 | 1.45e-03 | 1.35e-02 | 50 |
GO:00702022 | Colorectum | MSS | regulation of establishment of protein localization to chromosome | 7/3467 | 12/18723 | 2.45e-03 | 1.97e-02 | 7 |
GO:00062781 | Colorectum | MSS | RNA-dependent DNA biosynthetic process | 24/3467 | 75/18723 | 3.51e-03 | 2.61e-02 | 24 |
GO:19048512 | Colorectum | MSS | positive regulation of establishment of protein localization to telomere | 6/3467 | 10/18723 | 4.25e-03 | 3.04e-02 | 6 |
GO:0032210 | Colorectum | MSS | regulation of telomere maintenance via telomerase | 18/3467 | 53/18723 | 5.38e-03 | 3.66e-02 | 18 |
GO:00702031 | Colorectum | MSS | regulation of establishment of protein localization to telomere | 6/3467 | 11/18723 | 7.89e-03 | 4.84e-02 | 6 |
GO:19048691 | Colorectum | MSS | regulation of protein localization to Cajal body | 6/3467 | 11/18723 | 7.89e-03 | 4.84e-02 | 6 |
GO:19048711 | Colorectum | MSS | positive regulation of protein localization to Cajal body | 6/3467 | 11/18723 | 7.89e-03 | 4.84e-02 | 6 |
GO:00725943 | Colorectum | MSI-H | establishment of protein localization to organelle | 63/1319 | 422/18723 | 1.10e-08 | 1.33e-06 | 63 |
GO:19001823 | Colorectum | MSI-H | positive regulation of protein localization to nucleus | 21/1319 | 87/18723 | 4.60e-07 | 3.50e-05 | 21 |
GO:00510543 | Colorectum | MSI-H | positive regulation of DNA metabolic process | 34/1319 | 201/18723 | 1.60e-06 | 1.03e-04 | 34 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCT7 | SNV | Missense_Mutation | novel | c.938G>C | p.Arg313Pro | p.R313P | Q99832 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-A2-A3XV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CCT7 | SNV | Missense_Mutation | | c.667N>C | p.Ala223Pro | p.A223P | Q99832 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT7 | SNV | Missense_Mutation | rs541718985 | c.1339N>T | p.Arg447Cys | p.R447C | Q99832 | protein_coding | deleterious(0) | benign(0.12) | TCGA-AR-A1AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT7 | SNV | Missense_Mutation | novel | c.256N>A | p.Gln86Lys | p.Q86K | Q99832 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CCT7 | SNV | Missense_Mutation | novel | c.257N>T | p.Gln86Leu | p.Q86L | Q99832 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CCT7 | insertion | Frame_Shift_Ins | novel | c.117_118insT | p.Leu40SerfsTer21 | p.L40Sfs*21 | Q99832 | protein_coding | | | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CCT7 | insertion | Frame_Shift_Ins | novel | c.118_119insAAGCTCTTGGCATCTTGCATTT | p.Leu40GlnfsTer28 | p.L40Qfs*28 | Q99832 | protein_coding | | | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CCT7 | SNV | Missense_Mutation | novel | c.1242N>C | p.Met414Ile | p.M414I | Q99832 | protein_coding | deleterious(0.04) | possibly_damaging(0.744) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
CCT7 | SNV | Missense_Mutation | | c.779N>C | p.Val260Ala | p.V260A | Q99832 | protein_coding | tolerated(0.18) | possibly_damaging(0.672) | TCGA-F5-6811-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT7 | SNV | Missense_Mutation | novel | c.656N>T | p.Thr219Ile | p.T219I | Q99832 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |