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Gene: CAPG |
Gene summary for CAPG |
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Gene information | Species | Human | Gene symbol | CAPG | Gene ID | 822 |
Gene name | capping actin protein, gelsolin like | |
Gene Alias | AFCP | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | B2R9S4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
822 | CAPG | GSM4909282 | Human | Breast | IDC | 5.46e-30 | 6.45e-01 | -0.0288 |
822 | CAPG | GSM4909285 | Human | Breast | IDC | 3.73e-11 | 4.36e-01 | 0.21 |
822 | CAPG | GSM4909286 | Human | Breast | IDC | 6.18e-12 | -3.39e-01 | 0.1081 |
822 | CAPG | GSM4909294 | Human | Breast | IDC | 3.77e-05 | -1.80e-01 | 0.2022 |
822 | CAPG | GSM4909296 | Human | Breast | IDC | 8.95e-10 | 3.10e-01 | 0.1524 |
822 | CAPG | GSM4909297 | Human | Breast | IDC | 1.58e-08 | 1.44e-02 | 0.1517 |
822 | CAPG | GSM4909302 | Human | Breast | IDC | 4.91e-02 | -2.20e-01 | 0.1545 |
822 | CAPG | GSM4909305 | Human | Breast | IDC | 3.86e-04 | 3.37e-01 | 0.0436 |
822 | CAPG | GSM4909311 | Human | Breast | IDC | 1.83e-24 | -2.04e-01 | 0.1534 |
822 | CAPG | GSM4909312 | Human | Breast | IDC | 7.13e-09 | -3.35e-02 | 0.1552 |
822 | CAPG | GSM4909319 | Human | Breast | IDC | 1.46e-26 | -1.54e-01 | 0.1563 |
822 | CAPG | GSM4909320 | Human | Breast | IDC | 1.11e-03 | 6.14e-02 | 0.1575 |
822 | CAPG | GSM4909321 | Human | Breast | IDC | 6.99e-13 | 1.16e-01 | 0.1559 |
822 | CAPG | brca1 | Human | Breast | Precancer | 1.44e-16 | 5.48e-01 | -0.0338 |
822 | CAPG | brca2 | Human | Breast | Precancer | 7.22e-09 | 4.55e-01 | -0.024 |
822 | CAPG | brca3 | Human | Breast | Precancer | 2.17e-20 | 5.42e-01 | -0.0263 |
822 | CAPG | brca10 | Human | Breast | Precancer | 4.29e-05 | 3.95e-01 | -0.0029 |
822 | CAPG | NCCBC14 | Human | Breast | DCIS | 1.16e-08 | 3.47e-01 | 0.2021 |
822 | CAPG | NCCBC3 | Human | Breast | DCIS | 8.93e-25 | 6.45e-01 | 0.1198 |
822 | CAPG | NCCBC5 | Human | Breast | DCIS | 3.25e-15 | 3.51e-01 | 0.2046 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:011005325 | Cervix | N_HPV | regulation of actin filament organization | 16/534 | 278/18723 | 6.37e-03 | 4.37e-02 | 16 |
GO:005149413 | Cervix | N_HPV | negative regulation of cytoskeleton organization | 11/534 | 163/18723 | 7.17e-03 | 4.72e-02 | 11 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0010639 | Colorectum | AD | negative regulation of organelle organization | 114/3918 | 348/18723 | 1.41e-07 | 6.49e-06 | 114 |
GO:0032272 | Colorectum | AD | negative regulation of protein polymerization | 36/3918 | 80/18723 | 1.13e-06 | 3.72e-05 | 36 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CAPG | SNV | Missense_Mutation | c.181N>G | p.Leu61Val | p.L61V | P40121 | protein_coding | tolerated(0.11) | benign(0.04) | TCGA-D8-A1JD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CAPG | insertion | Frame_Shift_Ins | novel | c.463_464insAGCACAGCTGCATGCAAGCAGGGTGGAGGGGAGA | p.Leu155GlnfsTer58 | p.L155Qfs*58 | P40121 | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CAPG | SNV | Missense_Mutation | rs566538644 | c.967N>A | p.Ala323Thr | p.A323T | P40121 | protein_coding | deleterious(0.01) | benign(0) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CAPG | SNV | Missense_Mutation | c.902N>T | p.Ala301Val | p.A301V | P40121 | protein_coding | deleterious(0) | possibly_damaging(0.836) | TCGA-A6-2684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CAPG | SNV | Missense_Mutation | rs566538644 | c.967N>A | p.Ala323Thr | p.A323T | P40121 | protein_coding | deleterious(0.01) | benign(0) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
CAPG | SNV | Missense_Mutation | c.172G>T | p.Val58Phe | p.V58F | P40121 | protein_coding | tolerated(0.72) | benign(0.022) | TCGA-DM-A1D7-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CAPG | deletion | Frame_Shift_Del | c.19delN | p.Gln7ArgfsTer23 | p.Q7Rfs*23 | P40121 | protein_coding | TCGA-DC-5869-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |||
CAPG | SNV | Missense_Mutation | novel | c.103N>A | p.Ala35Thr | p.A35T | P40121 | protein_coding | deleterious(0) | benign(0.011) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CAPG | SNV | Missense_Mutation | novel | c.460N>T | p.Ala154Ser | p.A154S | P40121 | protein_coding | tolerated(0.15) | benign(0.083) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CAPG | SNV | Missense_Mutation | rs768616851 | c.955C>T | p.Arg319Cys | p.R319C | P40121 | protein_coding | tolerated(0.05) | possibly_damaging(0.809) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
822 | CAPG | NA | vincristine | VINCRISTINE |
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