Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/BAG5_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/BAG5_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/BAG5_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/BAG5_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/BAG5_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332112 | Liver | Cirrhotic | negative regulation of protein modification by small protein conjugation or removal | 40/4634 | 95/18723 | 1.50e-04 | 1.44e-03 | 40 |
GO:19032017 | Liver | Cirrhotic | regulation of oxidative stress-induced cell death | 33/4634 | 74/18723 | 1.51e-04 | 1.45e-03 | 33 |
GO:005134812 | Liver | Cirrhotic | negative regulation of transferase activity | 93/4634 | 268/18723 | 1.55e-04 | 1.47e-03 | 93 |
GO:19021767 | Liver | Cirrhotic | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 13/4634 | 20/18723 | 1.63e-04 | 1.54e-03 | 13 |
GO:00420267 | Liver | Cirrhotic | protein refolding | 14/4634 | 23/18723 | 2.50e-04 | 2.26e-03 | 14 |
GO:200005912 | Liver | Cirrhotic | negative regulation of ubiquitin-dependent protein catabolic process | 23/4634 | 48/18723 | 4.19e-04 | 3.45e-03 | 23 |
GO:00708416 | Liver | Cirrhotic | inclusion body assembly | 14/4634 | 24/18723 | 4.64e-04 | 3.75e-03 | 14 |
GO:00900835 | Liver | Cirrhotic | regulation of inclusion body assembly | 11/4634 | 17/18723 | 5.66e-04 | 4.44e-03 | 11 |
GO:19004077 | Liver | Cirrhotic | regulation of cellular response to oxidative stress | 36/4634 | 89/18723 | 7.79e-04 | 5.73e-03 | 36 |
GO:190336311 | Liver | Cirrhotic | negative regulation of cellular protein catabolic process | 31/4634 | 75/18723 | 1.15e-03 | 7.84e-03 | 31 |
GO:1903332 | Liver | Cirrhotic | regulation of protein folding | 8/4634 | 12/18723 | 2.59e-03 | 1.53e-02 | 8 |
GO:190305111 | Liver | Cirrhotic | negative regulation of proteolysis involved in cellular protein catabolic process | 26/4634 | 64/18723 | 3.69e-03 | 2.03e-02 | 26 |
GO:005143812 | Liver | Cirrhotic | regulation of ubiquitin-protein transferase activity | 22/4634 | 53/18723 | 5.36e-03 | 2.73e-02 | 22 |
GO:19032027 | Liver | Cirrhotic | negative regulation of oxidative stress-induced cell death | 22/4634 | 53/18723 | 5.36e-03 | 2.73e-02 | 22 |
GO:19028827 | Liver | Cirrhotic | regulation of response to oxidative stress | 36/4634 | 98/18723 | 5.44e-03 | 2.77e-02 | 36 |
GO:003243511 | Liver | Cirrhotic | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 16/4634 | 35/18723 | 5.53e-03 | 2.80e-02 | 16 |
GO:005144412 | Liver | Cirrhotic | negative regulation of ubiquitin-protein transferase activity | 10/4634 | 19/18723 | 8.23e-03 | 3.83e-02 | 10 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
GO:004217622 | Liver | HCC | regulation of protein catabolic process | 267/7958 | 391/18723 | 2.45e-25 | 7.38e-23 | 267 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BAG5 | SNV | Missense_Mutation | | c.349N>C | p.Glu117Gln | p.E117Q | Q9UL15 | protein_coding | tolerated(0.48) | probably_damaging(0.951) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
BAG5 | SNV | Missense_Mutation | novel | c.574N>T | p.His192Tyr | p.H192Y | Q9UL15 | protein_coding | deleterious_low_confidence(0) | benign(0.003) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
BAG5 | SNV | Missense_Mutation | novel | c.977N>T | p.Arg326Ile | p.R326I | Q9UL15 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.667) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAG5 | SNV | Missense_Mutation | | c.981N>A | p.Met327Ile | p.M327I | Q9UL15 | protein_coding | tolerated_low_confidence(0.12) | benign(0.083) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BAG5 | SNV | Missense_Mutation | novel | c.1057N>A | p.Gly353Ser | p.G353S | Q9UL15 | protein_coding | tolerated(0.19) | benign(0.009) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
BAG5 | SNV | Missense_Mutation | | c.981N>C | p.Met327Ile | p.M327I | Q9UL15 | protein_coding | tolerated_low_confidence(0.12) | benign(0.083) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAG5 | SNV | Missense_Mutation | | c.81N>C | p.Trp27Cys | p.W27C | Q9UL15 | protein_coding | deleterious_low_confidence(0) | benign(0.023) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAG5 | SNV | Missense_Mutation | novel | c.1431N>G | p.Ser477Arg | p.S477R | Q9UL15 | protein_coding | tolerated(0.07) | possibly_damaging(0.734) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BAG5 | insertion | Frame_Shift_Ins | novel | c.260_261insCT | p.Thr88Ter | p.T88* | Q9UL15 | protein_coding | | | TCGA-LP-A7HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
BAG5 | SNV | Missense_Mutation | | c.1438N>A | p.Asp480Asn | p.D480N | Q9UL15 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |