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Gene: AURKB |
Gene summary for AURKB |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | AURKB | Gene ID | 9212 |
| Gene name | aurora kinase B | |
| Gene Alias | AIK2 | |
| Cytomap | 17p13.1 | |
| Gene Type | protein-coding | GO ID | GO:0000022 | UniProtAcc | Q96GD4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9212 | AURKB | P2T-E | Human | Esophagus | ESCC | 9.44e-07 | 4.81e-01 | 0.1177 |
| 9212 | AURKB | P4T-E | Human | Esophagus | ESCC | 1.49e-09 | 3.93e-01 | 0.1323 |
| 9212 | AURKB | P5T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.77e-01 | 0.1327 |
| 9212 | AURKB | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 1.55e-01 | 0.0889 |
| 9212 | AURKB | P9T-E | Human | Esophagus | ESCC | 6.74e-06 | 2.10e-01 | 0.1131 |
| 9212 | AURKB | P10T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.30e-01 | 0.116 |
| 9212 | AURKB | P16T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.55e-01 | 0.1153 |
| 9212 | AURKB | P17T-E | Human | Esophagus | ESCC | 3.52e-10 | 8.08e-01 | 0.1278 |
| 9212 | AURKB | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 9.56e-01 | 0.1662 |
| 9212 | AURKB | P20T-E | Human | Esophagus | ESCC | 2.18e-03 | 2.45e-01 | 0.1124 |
| 9212 | AURKB | P21T-E | Human | Esophagus | ESCC | 4.12e-11 | 3.60e-01 | 0.1617 |
| 9212 | AURKB | P24T-E | Human | Esophagus | ESCC | 5.30e-21 | 6.19e-01 | 0.1287 |
| 9212 | AURKB | P28T-E | Human | Esophagus | ESCC | 1.33e-02 | 1.58e-01 | 0.1149 |
| 9212 | AURKB | P31T-E | Human | Esophagus | ESCC | 2.03e-09 | 3.49e-01 | 0.1251 |
| 9212 | AURKB | P32T-E | Human | Esophagus | ESCC | 2.56e-16 | 5.84e-01 | 0.1666 |
| 9212 | AURKB | P36T-E | Human | Esophagus | ESCC | 1.12e-05 | 3.33e-01 | 0.1187 |
| 9212 | AURKB | P37T-E | Human | Esophagus | ESCC | 1.03e-11 | 4.07e-01 | 0.1371 |
| 9212 | AURKB | P38T-E | Human | Esophagus | ESCC | 1.45e-09 | 5.86e-01 | 0.127 |
| 9212 | AURKB | P42T-E | Human | Esophagus | ESCC | 2.62e-05 | 2.92e-01 | 0.1175 |
| 9212 | AURKB | P44T-E | Human | Esophagus | ESCC | 6.93e-04 | 2.60e-01 | 0.1096 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:003209116 | Esophagus | ESCC | negative regulation of protein binding | 65/8552 | 94/18723 | 3.46e-06 | 3.82e-05 | 65 |
| GO:190199113 | Esophagus | ESCC | negative regulation of mitotic cell cycle phase transition | 112/8552 | 179/18723 | 3.69e-06 | 4.03e-05 | 112 |
| GO:00517831 | Esophagus | ESCC | regulation of nuclear division | 90/8552 | 139/18723 | 4.30e-06 | 4.60e-05 | 90 |
| GO:00900689 | Esophagus | ESCC | positive regulation of cell cycle process | 142/8552 | 236/18723 | 4.79e-06 | 5.08e-05 | 142 |
| GO:20012513 | Esophagus | ESCC | negative regulation of chromosome organization | 60/8552 | 86/18723 | 5.20e-06 | 5.45e-05 | 60 |
| GO:00086081 | Esophagus | ESCC | attachment of spindle microtubules to kinetochore | 29/8552 | 35/18723 | 6.61e-06 | 6.75e-05 | 29 |
| GO:00513151 | Esophagus | ESCC | attachment of mitotic spindle microtubules to kinetochore | 15/8552 | 15/18723 | 7.81e-06 | 7.69e-05 | 15 |
| GO:00458393 | Esophagus | ESCC | negative regulation of mitotic nuclear division | 37/8552 | 48/18723 | 8.99e-06 | 8.65e-05 | 37 |
| GO:00103891 | Esophagus | ESCC | regulation of G2/M transition of mitotic cell cycle | 64/8552 | 94/18723 | 9.21e-06 | 8.82e-05 | 64 |
| GO:19027491 | Esophagus | ESCC | regulation of cell cycle G2/M phase transition | 68/8552 | 102/18723 | 1.48e-05 | 1.33e-04 | 68 |
| GO:003220014 | Esophagus | ESCC | telomere organization | 99/8552 | 159/18723 | 1.77e-05 | 1.57e-04 | 99 |
| GO:000941611 | Esophagus | ESCC | response to light stimulus | 183/8552 | 320/18723 | 2.03e-05 | 1.76e-04 | 183 |
| GO:00513042 | Esophagus | ESCC | chromosome separation | 64/8552 | 96/18723 | 2.61e-05 | 2.20e-04 | 64 |
| GO:00517843 | Esophagus | ESCC | negative regulation of nuclear division | 41/8552 | 56/18723 | 2.64e-05 | 2.21e-04 | 41 |
| GO:00519882 | Esophagus | ESCC | regulation of attachment of spindle microtubules to kinetochore | 13/8552 | 13/18723 | 3.75e-05 | 3.04e-04 | 13 |
| GO:19043532 | Esophagus | ESCC | regulation of telomere capping | 22/8552 | 26/18723 | 4.88e-05 | 3.83e-04 | 22 |
| GO:00315772 | Esophagus | ESCC | spindle checkpoint | 30/8552 | 39/18723 | 6.93e-05 | 5.25e-04 | 30 |
| GO:00330472 | Esophagus | ESCC | regulation of mitotic sister chromatid segregation | 34/8552 | 46/18723 | 9.39e-05 | 6.70e-04 | 34 |
| GO:00070942 | Esophagus | ESCC | mitotic spindle assembly checkpoint | 29/8552 | 38/18723 | 1.18e-04 | 8.13e-04 | 29 |
| GO:00711732 | Esophagus | ESCC | spindle assembly checkpoint | 29/8552 | 38/18723 | 1.18e-04 | 8.13e-04 | 29 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
| hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
| hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
| hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| AURKB | SNV | Missense_Mutation | c.386N>C | p.Ile129Thr | p.I129T | Q96GD4 | protein_coding | deleterious(0) | possibly_damaging(0.566) | TCGA-D8-A1XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide+tamoxifen | SD | |
| AURKB | SNV | Missense_Mutation | rs749454960 | c.745N>T | p.Arg249Cys | p.R249C | Q96GD4 | protein_coding | deleterious(0.02) | benign(0.012) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| AURKB | SNV | Missense_Mutation | rs772022668 | c.481N>A | p.Gly161Arg | p.G161R | Q96GD4 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| AURKB | SNV | Missense_Mutation | c.371G>A | p.Arg124His | p.R124H | Q96GD4 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| AURKB | SNV | Missense_Mutation | c.595C>T | p.His199Tyr | p.H199Y | Q96GD4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| AURKB | SNV | Missense_Mutation | rs768656332 | c.897G>T | p.Met299Ile | p.M299I | Q96GD4 | protein_coding | tolerated(0.17) | benign(0) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| AURKB | SNV | Missense_Mutation | rs201709756 | c.1033N>A | p.Ala345Thr | p.A345T | Q96GD4 | protein_coding | deleterious_low_confidence(0.04) | benign(0.015) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| AURKB | SNV | Missense_Mutation | rs780771169 | c.89N>A | p.Arg30Gln | p.R30Q | Q96GD4 | protein_coding | tolerated(0.68) | benign(0.007) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| AURKB | SNV | Missense_Mutation | rs55871613 | c.539N>T | p.Thr180Met | p.T180M | Q96GD4 | protein_coding | deleterious(0.02) | benign(0.228) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| AURKB | SNV | Missense_Mutation | novel | c.50N>T | p.Ala17Val | p.A17V | Q96GD4 | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | ZM-447439 | CHEMBL202721 | ||
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | 178102344 | TOZASERTIB | |
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | LINIFANIB | LINIFANIB | ||
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | PAZOPANIB | PAZOPANIB | ||
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | CHEMBL495727 | AT-9283 | |
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | 249565620 | DANUSERTIB | |
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | CYC116 | |||
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | CHEMBL3545327 | TTP-607 | |
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | BAY-613606 | CHEMBL541400 | ||
| 9212 | AURKB | ENZYME, CLINICALLY ACTIONABLE, SERINE THREONINE KINASE, HISTONE MODIFICATION, DRUGGABLE GENOME, KINASE | inhibitor | 249565688 | CHEMBL1765740 |
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