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Gene: ASCL2 |
Gene summary for ASCL2 |
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Gene information | Species | Human | Gene symbol | ASCL2 | Gene ID | 430 |
Gene name | achaete-scute family bHLH transcription factor 2 | |
Gene Alias | ASH2 | |
Cytomap | 11p15.5 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q99929 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
430 | ASCL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.61e-11 | 3.47e-01 | 0.0155 |
430 | ASCL2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.24e-12 | 9.82e-01 | 0.0216 |
430 | ASCL2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.00e-04 | 4.40e-01 | -0.0811 |
430 | ASCL2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.88e-02 | 3.69e-01 | -0.1207 |
430 | ASCL2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.29e-13 | 5.95e-01 | -0.1464 |
430 | ASCL2 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.98e-02 | 2.02e-01 | -0.1001 |
430 | ASCL2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.85e-19 | 9.21e-01 | -0.059 |
430 | ASCL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.29e-62 | 1.56e+00 | 0.096 |
430 | ASCL2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.79e-19 | 1.35e+00 | 0.0451 |
430 | ASCL2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.44e-10 | 7.35e-01 | 0.0528 |
430 | ASCL2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 9.65e-05 | 8.67e-01 | 0.0131 |
430 | ASCL2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.97e-31 | 1.17e+00 | 0.0338 |
430 | ASCL2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 9.60e-63 | 1.50e+00 | 0.0674 |
430 | ASCL2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.92e-15 | 1.20e+00 | 0.0112 |
430 | ASCL2 | HTA11_11156_2000001011 | Human | Colorectum | AD | 4.45e-12 | 1.26e+00 | 0.0397 |
430 | ASCL2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.50e-40 | 1.39e+00 | 0.0588 |
430 | ASCL2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.80e-27 | 7.49e-01 | 0.294 |
430 | ASCL2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.05e-05 | 9.32e-01 | 0.3487 |
430 | ASCL2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.20e-39 | 1.35e+00 | 0.281 |
430 | ASCL2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.40e-49 | 1.10e+00 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00987277 | Oral cavity | OSCC | maintenance of cell number | 81/7305 | 134/18723 | 3.96e-07 | 5.90e-06 | 81 |
GO:00198276 | Oral cavity | OSCC | stem cell population maintenance | 79/7305 | 131/18723 | 6.28e-07 | 8.96e-06 | 79 |
GO:004860816 | Oral cavity | OSCC | reproductive structure development | 214/7305 | 424/18723 | 8.58e-07 | 1.18e-05 | 214 |
GO:00420635 | Oral cavity | OSCC | gliogenesis | 154/7305 | 301/18723 | 1.10e-05 | 1.14e-04 | 154 |
GO:00507679 | Oral cavity | OSCC | regulation of neurogenesis | 179/7305 | 364/18723 | 4.49e-05 | 3.84e-04 | 179 |
GO:000189216 | Oral cavity | OSCC | embryonic placenta development | 50/7305 | 82/18723 | 4.58e-05 | 3.90e-04 | 50 |
GO:0014009 | Oral cavity | OSCC | glial cell proliferation | 34/7305 | 51/18723 | 5.83e-05 | 4.80e-04 | 34 |
GO:00519605 | Oral cavity | OSCC | regulation of nervous system development | 205/7305 | 443/18723 | 9.80e-04 | 5.11e-03 | 205 |
GO:0060251 | Oral cavity | OSCC | regulation of glial cell proliferation | 23/7305 | 36/18723 | 2.19e-03 | 9.95e-03 | 23 |
GO:0014013 | Oral cavity | OSCC | regulation of gliogenesis | 54/7305 | 103/18723 | 3.85e-03 | 1.57e-02 | 54 |
GO:000170117 | Oral cavity | LP | in utero embryonic development | 142/4623 | 367/18723 | 1.48e-09 | 6.75e-08 | 142 |
GO:0070482110 | Oral cavity | LP | response to oxygen levels | 122/4623 | 347/18723 | 7.10e-06 | 1.37e-04 | 122 |
GO:0001666110 | Oral cavity | LP | response to hypoxia | 106/4623 | 307/18723 | 6.38e-05 | 8.61e-04 | 106 |
GO:004206313 | Oral cavity | LP | gliogenesis | 104/4623 | 301/18723 | 7.21e-05 | 9.49e-04 | 104 |
GO:000189018 | Oral cavity | LP | placenta development | 56/4623 | 144/18723 | 1.09e-04 | 1.31e-03 | 56 |
GO:0036293110 | Oral cavity | LP | response to decreased oxygen levels | 109/4623 | 322/18723 | 1.25e-04 | 1.46e-03 | 109 |
GO:000189217 | Oral cavity | LP | embryonic placenta development | 33/4623 | 82/18723 | 1.34e-03 | 1.07e-02 | 33 |
GO:006145818 | Oral cavity | LP | reproductive system development | 128/4623 | 427/18723 | 6.91e-03 | 3.96e-02 | 128 |
GO:004860817 | Oral cavity | LP | reproductive structure development | 127/4623 | 424/18723 | 7.31e-03 | 4.08e-02 | 127 |
GO:000170120 | Skin | AK | in utero embryonic development | 75/1910 | 367/18723 | 3.09e-09 | 2.62e-07 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ASCL2 | SNV | Missense_Mutation | novel | c.127N>T | p.Ala43Ser | p.A43S | Q99929 | protein_coding | tolerated(0.97) | benign(0.003) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ASCL2 | SNV | Missense_Mutation | novel | c.298N>G | p.Arg100Gly | p.R100G | Q99929 | protein_coding | deleterious(0) | possibly_damaging(0.581) | TCGA-2Y-A9GW-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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