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Gene: ARL8B |
Gene summary for ARL8B |
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Gene information | Species | Human | Gene symbol | ARL8B | Gene ID | 55207 |
Gene name | ADP ribosylation factor like GTPase 8B | |
Gene Alias | ARL10C | |
Cytomap | 3p26.1 | |
Gene Type | protein-coding | GO ID | GO:0001778 | UniProtAcc | A0A024R2D4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55207 | ARL8B | CCI_1 | Human | Cervix | CC | 1.98e-02 | 5.86e-01 | 0.528 |
55207 | ARL8B | CCI_2 | Human | Cervix | CC | 3.38e-05 | 8.49e-01 | 0.5249 |
55207 | ARL8B | CCI_3 | Human | Cervix | CC | 2.20e-06 | 9.81e-01 | 0.516 |
55207 | ARL8B | sample3 | Human | Cervix | CC | 4.99e-04 | 1.84e-01 | 0.1387 |
55207 | ARL8B | T3 | Human | Cervix | CC | 9.18e-04 | 2.03e-01 | 0.1389 |
55207 | ARL8B | LZE4T | Human | Esophagus | ESCC | 1.37e-17 | 7.25e-01 | 0.0811 |
55207 | ARL8B | LZE7T | Human | Esophagus | ESCC | 5.00e-03 | 2.78e-01 | 0.0667 |
55207 | ARL8B | LZE8T | Human | Esophagus | ESCC | 7.27e-04 | 4.46e-02 | 0.067 |
55207 | ARL8B | LZE20T | Human | Esophagus | ESCC | 6.17e-07 | 2.10e-01 | 0.0662 |
55207 | ARL8B | LZE24T | Human | Esophagus | ESCC | 3.92e-10 | 3.23e-01 | 0.0596 |
55207 | ARL8B | LZE21T | Human | Esophagus | ESCC | 3.54e-02 | 2.40e-02 | 0.0655 |
55207 | ARL8B | LZE6T | Human | Esophagus | ESCC | 1.16e-02 | 1.09e-01 | 0.0845 |
55207 | ARL8B | P2T-E | Human | Esophagus | ESCC | 1.27e-25 | 1.06e-01 | 0.1177 |
55207 | ARL8B | P4T-E | Human | Esophagus | ESCC | 3.63e-29 | 9.03e-01 | 0.1323 |
55207 | ARL8B | P5T-E | Human | Esophagus | ESCC | 2.37e-68 | 1.63e+00 | 0.1327 |
55207 | ARL8B | P8T-E | Human | Esophagus | ESCC | 7.72e-27 | 1.40e-01 | 0.0889 |
55207 | ARL8B | P9T-E | Human | Esophagus | ESCC | 4.25e-11 | 3.60e-01 | 0.1131 |
55207 | ARL8B | P10T-E | Human | Esophagus | ESCC | 1.46e-16 | 2.92e-01 | 0.116 |
55207 | ARL8B | P11T-E | Human | Esophagus | ESCC | 1.19e-06 | 5.70e-01 | 0.1426 |
55207 | ARL8B | P12T-E | Human | Esophagus | ESCC | 3.38e-24 | 7.13e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070401 | Liver | HCC | lysosome organization | 47/7958 | 74/18723 | 2.13e-04 | 1.63e-03 | 47 |
GO:00801711 | Liver | HCC | lytic vacuole organization | 47/7958 | 74/18723 | 2.13e-04 | 1.63e-03 | 47 |
GO:00901741 | Liver | HCC | organelle membrane fusion | 63/7958 | 110/18723 | 1.24e-03 | 6.85e-03 | 63 |
GO:00069061 | Liver | HCC | vesicle fusion | 61/7958 | 106/18723 | 1.25e-03 | 6.90e-03 | 61 |
GO:00083331 | Liver | HCC | endosome to lysosome transport | 35/7958 | 55/18723 | 1.26e-03 | 6.92e-03 | 35 |
GO:0008089 | Liver | HCC | anterograde axonal transport | 32/7958 | 50/18723 | 1.76e-03 | 9.12e-03 | 32 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
GO:0061025 | Liver | HCC | membrane fusion | 88/7958 | 163/18723 | 1.98e-03 | 1.00e-02 | 88 |
GO:000250411 | Liver | HCC | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 24/7958 | 36/18723 | 2.95e-03 | 1.38e-02 | 24 |
GO:00303012 | Liver | HCC | cholesterol transport | 65/7958 | 117/18723 | 2.95e-03 | 1.38e-02 | 65 |
GO:00159182 | Liver | HCC | sterol transport | 71/7958 | 130/18723 | 3.49e-03 | 1.58e-02 | 71 |
GO:00160328 | Lung | IAC | viral process | 94/2061 | 415/18723 | 5.11e-12 | 4.27e-09 | 94 |
GO:00190588 | Lung | IAC | viral life cycle | 77/2061 | 317/18723 | 1.23e-11 | 4.83e-09 | 77 |
GO:00521268 | Lung | IAC | movement in host environment | 48/2061 | 175/18723 | 1.30e-09 | 2.21e-07 | 48 |
GO:00517018 | Lung | IAC | biological process involved in interaction with host | 52/2061 | 203/18723 | 3.74e-09 | 5.84e-07 | 52 |
GO:00444038 | Lung | IAC | biological process involved in symbiotic interaction | 63/2061 | 290/18723 | 8.57e-08 | 8.34e-06 | 63 |
GO:00420608 | Lung | IAC | wound healing | 76/2061 | 422/18723 | 1.01e-05 | 3.23e-04 | 76 |
GO:00164826 | Lung | IAC | cytosolic transport | 37/2061 | 168/18723 | 2.74e-05 | 7.26e-04 | 37 |
GO:00307056 | Lung | IAC | cytoskeleton-dependent intracellular transport | 40/2061 | 195/18723 | 7.30e-05 | 1.54e-03 | 40 |
GO:00161976 | Lung | IAC | endosomal transport | 43/2061 | 230/18723 | 3.53e-04 | 5.50e-03 | 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132110 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa0513242 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513252 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513216 | Lung | IAC | Salmonella infection | 52/1053 | 249/8465 | 9.46e-05 | 1.28e-03 | 8.50e-04 | 52 |
hsa0513217 | Lung | IAC | Salmonella infection | 52/1053 | 249/8465 | 9.46e-05 | 1.28e-03 | 8.50e-04 | 52 |
hsa0513223 | Lung | AIS | Salmonella infection | 50/961 | 249/8465 | 3.47e-05 | 5.62e-04 | 3.59e-04 | 50 |
hsa0513233 | Lung | AIS | Salmonella infection | 50/961 | 249/8465 | 3.47e-05 | 5.62e-04 | 3.59e-04 | 50 |
hsa0513230 | Oral cavity | OSCC | Salmonella infection | 174/3704 | 249/8465 | 2.67e-17 | 1.49e-15 | 7.58e-16 | 174 |
hsa05132114 | Oral cavity | OSCC | Salmonella infection | 174/3704 | 249/8465 | 2.67e-17 | 1.49e-15 | 7.58e-16 | 174 |
hsa05132210 | Oral cavity | LP | Salmonella infection | 128/2418 | 249/8465 | 1.17e-14 | 2.79e-13 | 1.80e-13 | 128 |
hsa0513238 | Oral cavity | LP | Salmonella infection | 128/2418 | 249/8465 | 1.17e-14 | 2.79e-13 | 1.80e-13 | 128 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARL8B | SNV | Missense_Mutation | c.515N>G | p.Ile172Ser | p.I172S | Q9NVJ2 | protein_coding | tolerated(0.21) | benign(0.031) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ARL8B | SNV | Missense_Mutation | rs766948599 | c.323G>A | p.Arg108Gln | p.R108Q | Q9NVJ2 | protein_coding | tolerated(0.06) | benign(0.006) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ARL8B | SNV | Missense_Mutation | c.344N>C | p.Leu115Pro | p.L115P | Q9NVJ2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ARL8B | SNV | Missense_Mutation | rs780847749 | c.460N>A | p.Asp154Asn | p.D154N | Q9NVJ2 | protein_coding | tolerated(0.19) | benign(0.031) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
ARL8B | SNV | Missense_Mutation | c.150N>G | p.Ile50Met | p.I50M | Q9NVJ2 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL8B | SNV | Missense_Mutation | novel | c.308N>G | p.Lys103Arg | p.K103R | Q9NVJ2 | protein_coding | tolerated(0.09) | probably_damaging(0.966) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARL8B | SNV | Missense_Mutation | rs747994602 | c.193G>A | p.Val65Ile | p.V65I | Q9NVJ2 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-F4-6704-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ARL8B | SNV | Missense_Mutation | novel | c.538N>T | p.His180Tyr | p.H180Y | Q9NVJ2 | protein_coding | tolerated(0.09) | possibly_damaging(0.855) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARL8B | SNV | Missense_Mutation | novel | c.398A>G | p.Asp133Gly | p.D133G | Q9NVJ2 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARL8B | SNV | Missense_Mutation | rs747994602 | c.193G>A | p.Val65Ile | p.V65I | Q9NVJ2 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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