GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:01100534 | Colorectum | FAP | regulation of actin filament organization | 75/2622 | 278/18723 | 8.11e-09 | 1.10e-06 | 75 |
GO:00329564 | Colorectum | FAP | regulation of actin cytoskeleton organization | 90/2622 | 358/18723 | 1.20e-08 | 1.39e-06 | 90 |
GO:00510562 | Colorectum | FAP | regulation of small GTPase mediated signal transduction | 78/2622 | 302/18723 | 3.25e-08 | 2.85e-06 | 78 |
GO:00615723 | Colorectum | FAP | actin filament bundle organization | 49/2622 | 161/18723 | 5.69e-08 | 4.30e-06 | 49 |
GO:00510173 | Colorectum | FAP | actin filament bundle assembly | 48/2622 | 157/18723 | 6.62e-08 | 4.56e-06 | 48 |
GO:19029034 | Colorectum | FAP | regulation of supramolecular fiber organization | 92/2622 | 383/18723 | 8.48e-08 | 5.77e-06 | 92 |
GO:19029054 | Colorectum | FAP | positive regulation of supramolecular fiber organization | 57/2622 | 209/18723 | 3.28e-07 | 1.83e-05 | 57 |
GO:00514954 | Colorectum | FAP | positive regulation of cytoskeleton organization | 60/2622 | 226/18723 | 4.45e-07 | 2.37e-05 | 60 |
GO:00310323 | Colorectum | FAP | actomyosin structure organization | 51/2622 | 196/18723 | 5.89e-06 | 1.88e-04 | 51 |
GO:00322313 | Colorectum | FAP | regulation of actin filament bundle assembly | 30/2622 | 105/18723 | 7.54e-05 | 1.37e-03 | 30 |
GO:00069843 | Colorectum | FAP | ER-nucleus signaling pathway | 17/2622 | 46/18723 | 8.85e-05 | 1.57e-03 | 17 |
GO:00300383 | Colorectum | FAP | contractile actin filament bundle assembly | 30/2622 | 106/18723 | 9.12e-05 | 1.59e-03 | 30 |
GO:00431493 | Colorectum | FAP | stress fiber assembly | 30/2622 | 106/18723 | 9.12e-05 | 1.59e-03 | 30 |
GO:01100203 | Colorectum | FAP | regulation of actomyosin structure organization | 28/2622 | 100/18723 | 1.88e-04 | 2.76e-03 | 28 |
GO:00514922 | Colorectum | FAP | regulation of stress fiber assembly | 25/2622 | 91/18723 | 5.55e-04 | 6.22e-03 | 25 |
GO:00322333 | Colorectum | FAP | positive regulation of actin filament bundle assembly | 18/2622 | 63/18723 | 1.95e-03 | 1.65e-02 | 18 |
GO:00070155 | Colorectum | CRC | actin filament organization | 104/2078 | 442/18723 | 4.75e-14 | 7.12e-11 | 104 |
GO:00329705 | Colorectum | CRC | regulation of actin filament-based process | 89/2078 | 397/18723 | 5.25e-11 | 3.14e-08 | 89 |
GO:00510563 | Colorectum | CRC | regulation of small GTPase mediated signal transduction | 69/2078 | 302/18723 | 3.34e-09 | 9.08e-07 | 69 |
GO:19029035 | Colorectum | CRC | regulation of supramolecular fiber organization | 80/2078 | 383/18723 | 1.52e-08 | 2.75e-06 | 80 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARHGEF10L | SNV | Missense_Mutation | | c.1639N>T | p.Val547Leu | p.V547L | Q9HCE6 | protein_coding | deleterious(0.03) | probably_damaging(0.97) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD |
ARHGEF10L | SNV | Missense_Mutation | | c.1094N>A | p.Arg365His | p.R365H | Q9HCE6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF10L | SNV | Missense_Mutation | | c.1489G>A | p.Ala497Thr | p.A497T | Q9HCE6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARHGEF10L | SNV | Missense_Mutation | | c.1042N>A | p.Glu348Lys | p.E348K | Q9HCE6 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-E2-A1L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
ARHGEF10L | SNV | Missense_Mutation | | c.2288N>G | p.Pro763Arg | p.P763R | Q9HCE6 | protein_coding | tolerated(0.22) | probably_damaging(0.983) | TCGA-E9-A1NF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
ARHGEF10L | insertion | Nonsense_Mutation | novel | c.2470_2471insTAGTCATTCAGGAGCAGGTACTCTCAGAAAATTCTTTGTGACGAT | p.Gly824delinsValValIleGlnGluGlnValLeuSerGluAsnSerLeuTerArgCys | p.G824delinsVVIQEQVLSENSL*RC | Q9HCE6 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARHGEF10L | deletion | Frame_Shift_Del | | c.186delN | p.Pro64HisfsTer2 | p.P64Hfs*2 | Q9HCE6 | protein_coding | | | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
ARHGEF10L | deletion | Frame_Shift_Del | novel | c.1008delG | p.Lys336AsnfsTer11 | p.K336Nfs*11 | Q9HCE6 | protein_coding | | | TCGA-LL-A740-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ARHGEF10L | SNV | Missense_Mutation | rs776413301 | c.1384T>C | p.Phe462Leu | p.F462L | Q9HCE6 | protein_coding | deleterious(0.02) | benign(0.073) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ARHGEF10L | SNV | Missense_Mutation | | c.2334N>G | p.Phe778Leu | p.F778L | Q9HCE6 | protein_coding | tolerated(0.67) | possibly_damaging(0.81) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |