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Gene: ARHGAP24 |
Gene summary for ARHGAP24 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ARHGAP24 | Gene ID | 83478 |
| Gene name | Rho GTPase activating protein 24 | |
| Gene Alias | FILGAP | |
| Cytomap | 4q21.23-q21.3 | |
| Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q8N264 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 83478 | ARHGAP24 | CA_HPV_3 | Human | Cervix | CC | 1.01e-07 | 2.42e-01 | 0.0414 |
| 83478 | ARHGAP24 | CCI_1 | Human | Cervix | CC | 6.50e-23 | 1.41e+00 | 0.528 |
| 83478 | ARHGAP24 | CCI_3 | Human | Cervix | CC | 1.02e-12 | 6.60e-01 | 0.516 |
| 83478 | ARHGAP24 | LZE7T | Human | Esophagus | ESCC | 8.33e-05 | 2.57e-01 | 0.0667 |
| 83478 | ARHGAP24 | LZE8T | Human | Esophagus | ESCC | 2.23e-08 | 3.30e-01 | 0.067 |
| 83478 | ARHGAP24 | P1T-E | Human | Esophagus | ESCC | 2.74e-03 | 1.58e-01 | 0.0875 |
| 83478 | ARHGAP24 | P2T-E | Human | Esophagus | ESCC | 1.07e-31 | 5.87e-01 | 0.1177 |
| 83478 | ARHGAP24 | P4T-E | Human | Esophagus | ESCC | 1.01e-13 | 3.66e-01 | 0.1323 |
| 83478 | ARHGAP24 | P8T-E | Human | Esophagus | ESCC | 2.29e-04 | 1.15e-01 | 0.0889 |
| 83478 | ARHGAP24 | P9T-E | Human | Esophagus | ESCC | 1.02e-10 | 3.06e-01 | 0.1131 |
| 83478 | ARHGAP24 | P10T-E | Human | Esophagus | ESCC | 3.65e-13 | 2.22e-01 | 0.116 |
| 83478 | ARHGAP24 | P11T-E | Human | Esophagus | ESCC | 1.79e-04 | 2.95e-01 | 0.1426 |
| 83478 | ARHGAP24 | P12T-E | Human | Esophagus | ESCC | 1.55e-29 | 5.66e-01 | 0.1122 |
| 83478 | ARHGAP24 | P15T-E | Human | Esophagus | ESCC | 1.22e-15 | 3.84e-01 | 0.1149 |
| 83478 | ARHGAP24 | P16T-E | Human | Esophagus | ESCC | 1.92e-06 | 1.12e-01 | 0.1153 |
| 83478 | ARHGAP24 | P19T-E | Human | Esophagus | ESCC | 2.84e-04 | 6.22e-01 | 0.1662 |
| 83478 | ARHGAP24 | P20T-E | Human | Esophagus | ESCC | 4.61e-13 | 3.04e-01 | 0.1124 |
| 83478 | ARHGAP24 | P22T-E | Human | Esophagus | ESCC | 8.81e-06 | 1.63e-01 | 0.1236 |
| 83478 | ARHGAP24 | P23T-E | Human | Esophagus | ESCC | 8.83e-18 | 4.35e-01 | 0.108 |
| 83478 | ARHGAP24 | P26T-E | Human | Esophagus | ESCC | 6.01e-41 | 8.11e-01 | 0.1276 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00906302 | Lung | MIAC | activation of GTPase activity | 14/967 | 115/18723 | 2.42e-03 | 3.56e-02 | 14 |
| GO:012003221 | Lung | MIAC | regulation of plasma membrane bounded cell projection assembly | 19/967 | 186/18723 | 3.58e-03 | 4.56e-02 | 19 |
| GO:006049121 | Lung | MIAC | regulation of cell projection assembly | 19/967 | 188/18723 | 4.03e-03 | 4.84e-02 | 19 |
| GO:00420606 | Stomach | GC | wound healing | 52/1159 | 422/18723 | 1.63e-06 | 7.50e-05 | 52 |
| GO:0031529 | Stomach | GC | ruffle organization | 13/1159 | 56/18723 | 2.85e-05 | 7.90e-04 | 13 |
| GO:0097178 | Stomach | GC | ruffle assembly | 10/1159 | 44/18723 | 2.85e-04 | 4.64e-03 | 10 |
| GO:1900027 | Stomach | GC | regulation of ruffle assembly | 8/1159 | 31/18723 | 4.61e-04 | 6.81e-03 | 8 |
| GO:004206011 | Stomach | CAG with IM | wound healing | 49/1050 | 422/18723 | 1.11e-06 | 5.44e-05 | 49 |
| GO:00315291 | Stomach | CAG with IM | ruffle organization | 13/1050 | 56/18723 | 9.98e-06 | 3.37e-04 | 13 |
| GO:00971781 | Stomach | CAG with IM | ruffle assembly | 10/1050 | 44/18723 | 1.27e-04 | 2.64e-03 | 10 |
| GO:19000271 | Stomach | CAG with IM | regulation of ruffle assembly | 8/1050 | 31/18723 | 2.36e-04 | 4.25e-03 | 8 |
| GO:01200325 | Stomach | CAG with IM | regulation of plasma membrane bounded cell projection assembly | 20/1050 | 186/18723 | 3.99e-03 | 3.46e-02 | 20 |
| GO:00604914 | Stomach | CAG with IM | regulation of cell projection assembly | 20/1050 | 188/18723 | 4.50e-03 | 3.77e-02 | 20 |
| GO:004206021 | Stomach | CSG | wound healing | 49/1034 | 422/18723 | 7.12e-07 | 3.77e-05 | 49 |
| GO:00315292 | Stomach | CSG | ruffle organization | 13/1034 | 56/18723 | 8.46e-06 | 3.00e-04 | 13 |
| GO:00971782 | Stomach | CSG | ruffle assembly | 10/1034 | 44/18723 | 1.12e-04 | 2.42e-03 | 10 |
| GO:19000272 | Stomach | CSG | regulation of ruffle assembly | 8/1034 | 31/18723 | 2.13e-04 | 4.04e-03 | 8 |
| GO:012003211 | Stomach | CSG | regulation of plasma membrane bounded cell projection assembly | 20/1034 | 186/18723 | 3.36e-03 | 3.04e-02 | 20 |
| GO:006049111 | Stomach | CSG | regulation of cell projection assembly | 20/1034 | 188/18723 | 3.80e-03 | 3.36e-02 | 20 |
| GO:004206030 | Thyroid | HT | wound healing | 60/1272 | 422/18723 | 4.06e-08 | 2.69e-06 | 60 |
| Page: 1 2 3 4 5 6 7 8 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ARHGAP24 | SNV | Missense_Mutation | novel | c.2090N>C | p.Ile697Thr | p.I697T | Q8N264 | protein_coding | deleterious(0) | benign(0.039) | TCGA-AC-A2FE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
| ARHGAP24 | SNV | Missense_Mutation | c.1666N>C | p.Ser556Pro | p.S556P | Q8N264 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ARHGAP24 | SNV | Missense_Mutation | rs553105622 | c.869C>T | p.Thr290Met | p.T290M | Q8N264 | protein_coding | deleterious(0) | probably_damaging(0.916) | TCGA-BH-A0HB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
| ARHGAP24 | SNV | Missense_Mutation | c.2070G>C | p.Glu690Asp | p.E690D | Q8N264 | protein_coding | deleterious(0.02) | probably_damaging(0.978) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| ARHGAP24 | SNV | Missense_Mutation | c.298N>T | p.His100Tyr | p.H100Y | Q8N264 | protein_coding | deleterious(0.04) | benign(0.026) | TCGA-D8-A1JL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| ARHGAP24 | SNV | Missense_Mutation | rs768287557 | c.424C>T | p.Arg142Cys | p.R142C | Q8N264 | protein_coding | deleterious(0.03) | possibly_damaging(0.84) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
| ARHGAP24 | SNV | Missense_Mutation | c.1816G>T | p.Asp606Tyr | p.D606Y | Q8N264 | protein_coding | deleterious(0) | possibly_damaging(0.656) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| ARHGAP24 | insertion | Frame_Shift_Ins | novel | c.1419_1420insTCCATTT | p.Thr474SerfsTer43 | p.T474Sfs*43 | Q8N264 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
| ARHGAP24 | insertion | Frame_Shift_Ins | novel | c.1421_1422insAGATGCCACTAAAATATCTT | p.His475AspfsTer20 | p.H475Dfs*20 | Q8N264 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
| ARHGAP24 | insertion | Frame_Shift_Ins | novel | c.1455_1456insAATATAAATAA | p.Ile486AsnfsTer6 | p.I486Nfs*6 | Q8N264 | protein_coding | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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