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Gene: ANXA1 |
Gene summary for ANXA1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ANXA1 | Gene ID | 301 |
Gene name | annexin A1 | |
Gene Alias | ANX1 | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P04083 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
301 | ANXA1 | GSM4909281 | Human | Breast | IDC | 9.72e-06 | -3.81e-01 | 0.21 |
301 | ANXA1 | GSM4909282 | Human | Breast | IDC | 9.16e-07 | -1.64e-01 | -0.0288 |
301 | ANXA1 | GSM4909285 | Human | Breast | IDC | 6.68e-16 | -5.41e-01 | 0.21 |
301 | ANXA1 | GSM4909286 | Human | Breast | IDC | 3.03e-23 | -8.52e-01 | 0.1081 |
301 | ANXA1 | GSM4909287 | Human | Breast | IDC | 8.76e-03 | -3.28e-01 | 0.2057 |
301 | ANXA1 | GSM4909290 | Human | Breast | IDC | 5.24e-23 | -9.23e-01 | 0.2096 |
301 | ANXA1 | GSM4909291 | Human | Breast | IDC | 1.57e-23 | -1.00e+00 | 0.1753 |
301 | ANXA1 | GSM4909292 | Human | Breast | IDC | 2.62e-07 | -1.08e+00 | 0.1236 |
301 | ANXA1 | GSM4909293 | Human | Breast | IDC | 1.21e-21 | -7.81e-01 | 0.1581 |
301 | ANXA1 | GSM4909294 | Human | Breast | IDC | 1.44e-29 | -8.53e-01 | 0.2022 |
301 | ANXA1 | GSM4909296 | Human | Breast | IDC | 1.71e-36 | -9.89e-01 | 0.1524 |
301 | ANXA1 | GSM4909297 | Human | Breast | IDC | 6.02e-27 | -7.85e-01 | 0.1517 |
301 | ANXA1 | GSM4909298 | Human | Breast | IDC | 1.37e-29 | -8.73e-01 | 0.1551 |
301 | ANXA1 | GSM4909299 | Human | Breast | IDC | 1.47e-07 | 4.25e-01 | 0.035 |
301 | ANXA1 | GSM4909301 | Human | Breast | IDC | 2.31e-49 | -1.06e+00 | 0.1577 |
301 | ANXA1 | GSM4909302 | Human | Breast | IDC | 1.39e-28 | -9.03e-01 | 0.1545 |
301 | ANXA1 | GSM4909303 | Human | Breast | IDC | 5.04e-07 | -8.20e-01 | 0.0438 |
301 | ANXA1 | GSM4909304 | Human | Breast | IDC | 4.09e-44 | -1.05e+00 | 0.1636 |
301 | ANXA1 | GSM4909306 | Human | Breast | IDC | 5.39e-14 | -6.64e-01 | 0.1564 |
301 | ANXA1 | GSM4909307 | Human | Breast | IDC | 1.98e-15 | -6.60e-01 | 0.1569 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00158336 | Breast | Precancer | peptide transport | 27/1080 | 264/18723 | 2.84e-03 | 2.49e-02 | 27 |
GO:00620126 | Breast | Precancer | regulation of small molecule metabolic process | 32/1080 | 334/18723 | 3.45e-03 | 2.87e-02 | 32 |
GO:19030348 | Breast | Precancer | regulation of response to wounding | 19/1080 | 167/18723 | 3.60e-03 | 2.98e-02 | 19 |
GO:0030217 | Breast | Precancer | T cell differentiation | 26/1080 | 257/18723 | 3.89e-03 | 3.10e-02 | 26 |
GO:0045620 | Breast | Precancer | negative regulation of lymphocyte differentiation | 9/1080 | 55/18723 | 3.95e-03 | 3.15e-02 | 9 |
GO:00703013 | Breast | Precancer | cellular response to hydrogen peroxide | 13/1080 | 98/18723 | 4.09e-03 | 3.22e-02 | 13 |
GO:00300736 | Breast | Precancer | insulin secretion | 21/1080 | 195/18723 | 4.38e-03 | 3.42e-02 | 21 |
GO:00716926 | Breast | Precancer | protein localization to extracellular region | 34/1080 | 368/18723 | 4.65e-03 | 3.58e-02 | 34 |
GO:0033028 | Breast | Precancer | myeloid cell apoptotic process | 6/1080 | 29/18723 | 5.49e-03 | 4.01e-02 | 6 |
GO:00506704 | Breast | Precancer | regulation of lymphocyte proliferation | 23/1080 | 225/18723 | 5.62e-03 | 4.08e-02 | 23 |
GO:00093067 | Breast | Precancer | protein secretion | 33/1080 | 359/18723 | 5.65e-03 | 4.08e-02 | 33 |
GO:00355927 | Breast | Precancer | establishment of protein localization to extracellular region | 33/1080 | 360/18723 | 5.89e-03 | 4.21e-02 | 33 |
GO:00706655 | Breast | Precancer | positive regulation of leukocyte proliferation | 17/1080 | 150/18723 | 5.92e-03 | 4.21e-02 | 17 |
GO:0006925 | Breast | Precancer | inflammatory cell apoptotic process | 5/1080 | 21/18723 | 5.93e-03 | 4.21e-02 | 5 |
GO:00329443 | Breast | Precancer | regulation of mononuclear cell proliferation | 23/1080 | 227/18723 | 6.24e-03 | 4.40e-02 | 23 |
GO:00423044 | Breast | Precancer | regulation of fatty acid biosynthetic process | 8/1080 | 49/18723 | 6.53e-03 | 4.51e-02 | 8 |
GO:2000106 | Breast | Precancer | regulation of leukocyte apoptotic process | 11/1080 | 81/18723 | 6.65e-03 | 4.57e-02 | 11 |
GO:00027904 | Breast | Precancer | peptide secretion | 24/1080 | 242/18723 | 6.87e-03 | 4.67e-02 | 24 |
GO:00226049 | Breast | Precancer | regulation of cell morphogenesis | 29/1080 | 309/18723 | 6.88e-03 | 4.67e-02 | 29 |
GO:004854514 | Breast | IDC | response to steroid hormone | 70/1434 | 339/18723 | 1.34e-14 | 4.23e-12 | 70 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Breast | DCIS |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Breast | IDC |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | Cervix | ADJ |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Cervix | ADJ |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | Cervix | CC |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Cervix | CC |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | Cervix | Healthy |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Cervix | Healthy |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | Cervix | Precancer |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Cervix | Precancer |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | CRC | AD |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | CRC | MSI-H |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Endometrium | ADJ |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Endometrium | AEH |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Endometrium | EEC |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | GC | ADJ |
ANXA1 | FPR2 | ANXA1_FPR2 | ANNEXIN | HNSCC | ADJ |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | HNSCC | ADJ |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | HNSCC | Healthy |
ANXA1 | FPR1 | ANXA1_FPR1 | ANNEXIN | Liver | HCC |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ANXA1 | PANIN | Pancreas | Healthy | VIM,LMNA,CAV1, etc. | 2.06e-01 | |
ANXA1 | LYMEND | Thyroid | ADJ | TPSB2,S100A10,ANXA2, etc. | 4.63e-01 |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANXA1 | SNV | Missense_Mutation | novel | c.428C>T | p.Ser143Leu | p.S143L | P04083 | protein_coding | deleterious(0) | possibly_damaging(0.794) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
ANXA1 | SNV | Missense_Mutation | novel | c.37N>C | p.Phe13Leu | p.F13L | P04083 | protein_coding | tolerated(0.4) | benign(0.162) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
ANXA1 | SNV | Missense_Mutation | c.80C>T | p.Ser27Leu | p.S27L | P04083 | protein_coding | tolerated(0.15) | benign(0) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ANXA1 | SNV | Missense_Mutation | novel | c.598G>A | p.Asp200Asn | p.D200N | P04083 | protein_coding | deleterious(0.02) | possibly_damaging(0.71) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
ANXA1 | SNV | Missense_Mutation | novel | c.168N>A | p.Met56Ile | p.M56I | P04083 | protein_coding | deleterious(0.01) | benign(0.04) | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
ANXA1 | SNV | Missense_Mutation | c.604G>A | p.Asp202Asn | p.D202N | P04083 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AY-A71X-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ANXA1 | SNV | Missense_Mutation | c.831C>A | p.Phe277Leu | p.F277L | P04083 | protein_coding | deleterious(0.01) | possibly_damaging(0.5) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
ANXA1 | SNV | Missense_Mutation | novel | c.881A>G | p.Lys294Arg | p.K294R | P04083 | protein_coding | tolerated(0.41) | benign(0.021) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ANXA1 | SNV | Missense_Mutation | rs142849845 | c.97N>A | p.Gly33Arg | p.G33R | P04083 | protein_coding | tolerated(0.27) | benign(0.037) | TCGA-CK-4948-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ANXA1 | SNV | Missense_Mutation | c.901N>A | p.Val301Ile | p.V301I | P04083 | protein_coding | deleterious(0.02) | probably_damaging(0.945) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | RIMEXOLONE | RIMEXOLONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | CLOCORTOLONE | CLOCORTOLONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | PREDNISOLONE | PREDNISOLONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | BECLOMETHASONE | BECLOMETHASONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | MOMETASONE | MOMETASONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | METHYLPREDNISOLONE | METHYLPREDNISOLONE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | AMCINONIDE | AMCINONIDE | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | PPD | 11468004 | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | CLOBETASOL | CLOBETASOL | ||
301 | ANXA1 | CELL SURFACE, DRUGGABLE GENOME | HYDROCORTISONE | HYDROCORTISONE | 1712816 |
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