Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ANKFY1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ANKFY1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ANKFY1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ANKFY1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004580716 | Prostate | Tumor | positive regulation of endocytosis | 33/3246 | 100/18723 | 1.04e-04 | 1.00e-03 | 33 |
GO:001619713 | Prostate | Tumor | endosomal transport | 62/3246 | 230/18723 | 1.65e-04 | 1.47e-03 | 62 |
GO:000704113 | Prostate | Tumor | lysosomal transport | 34/3246 | 114/18723 | 7.00e-04 | 4.92e-03 | 34 |
GO:00485481 | Prostate | Tumor | regulation of pinocytosis | 6/3246 | 12/18723 | 9.63e-03 | 4.10e-02 | 6 |
GO:004214712 | Prostate | Tumor | retrograde transport, endosome to Golgi | 25/3246 | 91/18723 | 1.05e-02 | 4.38e-02 | 25 |
GO:004819320 | Thyroid | PTC | Golgi vesicle transport | 186/5968 | 296/18723 | 3.09e-28 | 1.22e-25 | 186 |
GO:001605017 | Thyroid | PTC | vesicle organization | 163/5968 | 300/18723 | 4.74e-16 | 3.69e-14 | 163 |
GO:001619718 | Thyroid | PTC | endosomal transport | 128/5968 | 230/18723 | 6.26e-14 | 3.52e-12 | 128 |
GO:000689218 | Thyroid | PTC | post-Golgi vesicle-mediated transport | 66/5968 | 104/18723 | 3.36e-11 | 1.24e-09 | 66 |
GO:0007034110 | Thyroid | PTC | vacuolar transport | 90/5968 | 157/18723 | 3.74e-11 | 1.35e-09 | 90 |
GO:001648217 | Thyroid | PTC | cytosolic transport | 92/5968 | 168/18723 | 6.41e-10 | 1.97e-08 | 92 |
GO:003010020 | Thyroid | PTC | regulation of endocytosis | 108/5968 | 211/18723 | 3.92e-09 | 1.04e-07 | 108 |
GO:004580720 | Thyroid | PTC | positive regulation of endocytosis | 58/5968 | 100/18723 | 6.11e-08 | 1.28e-06 | 58 |
GO:000704115 | Thyroid | PTC | lysosomal transport | 63/5968 | 114/18723 | 1.97e-07 | 3.54e-06 | 63 |
GO:00482846 | Thyroid | PTC | organelle fusion | 71/5968 | 141/18723 | 3.68e-06 | 4.70e-05 | 71 |
GO:00421479 | Thyroid | PTC | retrograde transport, endosome to Golgi | 48/5968 | 91/18723 | 2.86e-05 | 2.78e-04 | 48 |
GO:00610256 | Thyroid | PTC | membrane fusion | 77/5968 | 163/18723 | 2.86e-05 | 2.78e-04 | 77 |
GO:00069065 | Thyroid | PTC | vesicle fusion | 54/5968 | 106/18723 | 3.39e-05 | 3.21e-04 | 54 |
GO:00901745 | Thyroid | PTC | organelle membrane fusion | 55/5968 | 110/18723 | 5.64e-05 | 4.99e-04 | 55 |
GO:00069074 | Thyroid | PTC | pinocytosis | 14/5968 | 22/18723 | 2.16e-03 | 1.15e-02 | 14 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKFY1 | SNV | Missense_Mutation | | c.470T>C | p.Met157Thr | p.M157T | Q9P2R3 | protein_coding | tolerated(0.41) | benign(0.023) | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ANKFY1 | SNV | Missense_Mutation | | c.793N>T | p.His265Tyr | p.H265Y | Q9P2R3 | protein_coding | deleterious(0) | benign(0.421) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKFY1 | SNV | Missense_Mutation | rs768383868 | c.923G>A | p.Arg308Gln | p.R308Q | Q9P2R3 | protein_coding | tolerated(0.58) | benign(0.003) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKFY1 | SNV | Missense_Mutation | novel | c.1851N>A | p.Asn617Lys | p.N617K | Q9P2R3 | protein_coding | tolerated(0.27) | benign(0.124) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ANKFY1 | SNV | Missense_Mutation | rs745379002 | c.712N>A | p.Asp238Asn | p.D238N | Q9P2R3 | protein_coding | tolerated(0.08) | benign(0.311) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKFY1 | SNV | Missense_Mutation | | c.2159G>C | p.Gly720Ala | p.G720A | Q9P2R3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKFY1 | insertion | Nonsense_Mutation | novel | c.2211_2212insGCTGCCTGAGCTCCTGTAGTCACG | p.Ala737_Leu738insAlaAlaTerAlaProValValThr | p.A737_L738insAA*APVVT | Q9P2R3 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
ANKFY1 | insertion | Nonsense_Mutation | novel | c.2161_2162insTCTTGGCATGCCAGTAGCCGGCTTGACTTTCACAGTTAAGGTTATCA | p.Ala721ValfsTer6 | p.A721Vfs*6 | Q9P2R3 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
ANKFY1 | insertion | Nonsense_Mutation | novel | c.915_916insACGTAGACATCAAAGAGAGAATCTA | p.Leu306ThrfsTer2 | p.L306Tfs*2 | Q9P2R3 | protein_coding | | | TCGA-AN-A0AS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ANKFY1 | insertion | Frame_Shift_Ins | novel | c.3043_3044insTTTATCCACCATCACAGAGTTCAGAAAATTCT | p.Asn1015IlefsTer31 | p.N1015Ifs*31 | Q9P2R3 | protein_coding | | | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |