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Gene: ADAMTS9 |
Gene summary for ADAMTS9 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ADAMTS9 | Gene ID | 56999 |
| Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 9 | |
| Gene Alias | ADAMTS9 | |
| Cytomap | 3p14.1 | |
| Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q9P2N4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 56999 | ADAMTS9 | P2T-E | Human | Esophagus | ESCC | 1.76e-53 | 1.02e+00 | 0.1177 |
| 56999 | ADAMTS9 | P16T-E | Human | Esophagus | ESCC | 5.05e-19 | 4.43e-01 | 0.1153 |
| 56999 | ADAMTS9 | P56T-E | Human | Esophagus | ESCC | 2.00e-05 | 8.99e-01 | 0.1613 |
| 56999 | ADAMTS9 | P76T-E | Human | Esophagus | ESCC | 1.03e-05 | 1.87e-01 | 0.1207 |
| 56999 | ADAMTS9 | C21 | Human | Oral cavity | OSCC | 1.31e-07 | -6.00e-01 | 0.2678 |
| 56999 | ADAMTS9 | C43 | Human | Oral cavity | OSCC | 1.80e-11 | -6.00e-01 | 0.1704 |
| 56999 | ADAMTS9 | C46 | Human | Oral cavity | OSCC | 1.57e-13 | -6.00e-01 | 0.1673 |
| 56999 | ADAMTS9 | C57 | Human | Oral cavity | OSCC | 5.39e-09 | -6.00e-01 | 0.1679 |
| 56999 | ADAMTS9 | C08 | Human | Oral cavity | OSCC | 3.58e-12 | -5.83e-01 | 0.1919 |
| 56999 | ADAMTS9 | C09 | Human | Oral cavity | OSCC | 4.40e-02 | -3.68e-01 | 0.1431 |
| 56999 | ADAMTS9 | LN46 | Human | Oral cavity | OSCC | 1.36e-05 | -6.00e-01 | 0.1666 |
| 56999 | ADAMTS9 | EOLP-2 | Human | Oral cavity | EOLP | 9.21e-03 | -3.18e-01 | -0.0203 |
| 56999 | ADAMTS9 | NEOLP-3 | Human | Oral cavity | NEOLP | 2.06e-02 | 4.05e-01 | -0.0191 |
| 56999 | ADAMTS9 | SYSMH1 | Human | Oral cavity | OSCC | 3.41e-13 | -6.00e-01 | 0.1127 |
| 56999 | ADAMTS9 | SYSMH2 | Human | Oral cavity | OSCC | 2.36e-11 | -5.87e-01 | 0.2326 |
| 56999 | ADAMTS9 | SYSMH3 | Human | Oral cavity | OSCC | 3.09e-14 | -6.00e-01 | 0.2442 |
| 56999 | ADAMTS9 | SYSMH4 | Human | Oral cavity | OSCC | 3.08e-12 | -6.00e-01 | 0.1226 |
| 56999 | ADAMTS9 | SYSMH5 | Human | Oral cavity | OSCC | 6.15e-15 | -5.98e-01 | 0.0647 |
| 56999 | ADAMTS9 | SYSMH6 | Human | Oral cavity | OSCC | 3.44e-12 | -5.70e-01 | 0.1275 |
| 56999 | ADAMTS9 | 047563_1562-all-cells | Human | Prostate | BPH | 3.39e-27 | 6.74e-01 | 0.0791 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:009013016 | Prostate | BPH | tissue migration | 105/3107 | 365/18723 | 3.21e-09 | 1.24e-07 | 105 |
| GO:001063116 | Prostate | BPH | epithelial cell migration | 103/3107 | 357/18723 | 3.80e-09 | 1.44e-07 | 103 |
| GO:000166717 | Prostate | BPH | ameboidal-type cell migration | 128/3107 | 475/18723 | 5.69e-09 | 2.05e-07 | 128 |
| GO:001063216 | Prostate | BPH | regulation of epithelial cell migration | 87/3107 | 292/18723 | 1.18e-08 | 3.87e-07 | 87 |
| GO:000716010 | Prostate | BPH | cell-matrix adhesion | 72/3107 | 233/18723 | 4.17e-08 | 1.16e-06 | 72 |
| GO:00512715 | Prostate | BPH | negative regulation of cellular component movement | 94/3107 | 367/18723 | 6.18e-06 | 9.00e-05 | 94 |
| GO:20001465 | Prostate | BPH | negative regulation of cell motility | 91/3107 | 359/18723 | 1.34e-05 | 1.76e-04 | 91 |
| GO:00605377 | Prostate | BPH | muscle tissue development | 100/3107 | 403/18723 | 1.35e-05 | 1.76e-04 | 100 |
| GO:00435429 | Prostate | BPH | endothelial cell migration | 73/3107 | 279/18723 | 3.03e-05 | 3.46e-04 | 73 |
| GO:00400135 | Prostate | BPH | negative regulation of locomotion | 96/3107 | 391/18723 | 3.11e-05 | 3.54e-04 | 96 |
| GO:00303365 | Prostate | BPH | negative regulation of cell migration | 86/3107 | 344/18723 | 3.93e-05 | 4.25e-04 | 86 |
| GO:00105946 | Prostate | BPH | regulation of endothelial cell migration | 61/3107 | 232/18723 | 1.13e-04 | 1.03e-03 | 61 |
| GO:0003170 | Prostate | BPH | heart valve development | 23/3107 | 65/18723 | 1.87e-04 | 1.55e-03 | 23 |
| GO:00147066 | Prostate | BPH | striated muscle tissue development | 91/3107 | 384/18723 | 1.90e-04 | 1.57e-03 | 91 |
| GO:0003179 | Prostate | BPH | heart valve morphogenesis | 20/3107 | 55/18723 | 3.18e-04 | 2.43e-03 | 20 |
| GO:19013424 | Prostate | BPH | regulation of vasculature development | 78/3107 | 348/18723 | 2.76e-03 | 1.46e-02 | 78 |
| GO:00457654 | Prostate | BPH | regulation of angiogenesis | 76/3107 | 342/18723 | 3.90e-03 | 1.95e-02 | 76 |
| GO:00430621 | Prostate | BPH | extracellular structure organization | 67/3107 | 302/18723 | 6.67e-03 | 3.00e-02 | 67 |
| GO:00301981 | Prostate | BPH | extracellular matrix organization | 66/3107 | 301/18723 | 9.20e-03 | 3.92e-02 | 66 |
| GO:00452291 | Prostate | BPH | external encapsulating structure organization | 66/3107 | 304/18723 | 1.15e-02 | 4.66e-02 | 66 |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ADAMTS9 | SNV | Missense_Mutation | c.1226N>A | p.Gly409Glu | p.G409E | Q9P2N4 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| ADAMTS9 | SNV | Missense_Mutation | c.5698N>C | p.Ser1900Pro | p.S1900P | Q9P2N4 | protein_coding | tolerated(0.13) | possibly_damaging(0.718) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
| ADAMTS9 | SNV | Missense_Mutation | novel | c.2728N>G | p.Gln910Glu | p.Q910E | Q9P2N4 | protein_coding | tolerated(0.07) | benign(0.096) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
| ADAMTS9 | SNV | Missense_Mutation | c.3422N>T | p.Ser1141Leu | p.S1141L | Q9P2N4 | protein_coding | tolerated(0.1) | benign(0.044) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| ADAMTS9 | SNV | Missense_Mutation | rs775861579 | c.4717N>A | p.Glu1573Lys | p.E1573K | Q9P2N4 | protein_coding | tolerated(0.94) | benign(0.044) | TCGA-AC-A5XU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
| ADAMTS9 | SNV | Missense_Mutation | rs749861523 | c.4837N>A | p.Glu1613Lys | p.E1613K | Q9P2N4 | protein_coding | tolerated(0.87) | benign(0.007) | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| ADAMTS9 | SNV | Missense_Mutation | novel | c.5272A>G | p.Ile1758Val | p.I1758V | Q9P2N4 | protein_coding | tolerated(1) | benign(0.009) | TCGA-AO-A1KT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
| ADAMTS9 | SNV | Missense_Mutation | c.4658G>A | p.Arg1553Gln | p.R1553Q | Q9P2N4 | protein_coding | tolerated(0.29) | benign(0) | TCGA-B6-A408-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
| ADAMTS9 | SNV | Missense_Mutation | c.4495C>T | p.Pro1499Ser | p.P1499S | Q9P2N4 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
| ADAMTS9 | SNV | Missense_Mutation | c.2533N>T | p.Ile845Phe | p.I845F | Q9P2N4 | protein_coding | deleterious(0.01) | probably_damaging(0.914) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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