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Gene: ACOT1 |
Gene summary for ACOT1 |
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Gene information | Species | Human | Gene symbol | ACOT1 | Gene ID | 641371 |
Gene name | acyl-CoA thioesterase 1 | |
Gene Alias | ACH2 | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000038 | UniProtAcc | E9KL42 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
641371 | ACOT1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.23e-02 | 1.22e-01 | 0.0155 |
641371 | ACOT1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.79e-03 | 2.40e-01 | -0.1808 |
641371 | ACOT1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.01e-04 | 2.64e-01 | -0.0811 |
641371 | ACOT1 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.53e-08 | 2.69e-01 | -0.1088 |
641371 | ACOT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.48e-14 | 3.67e-01 | -0.1954 |
641371 | ACOT1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.25e-03 | 4.37e-01 | -0.2602 |
641371 | ACOT1 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.76e-05 | 2.69e-01 | -0.1526 |
641371 | ACOT1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.35e-07 | 2.27e-01 | -0.1464 |
641371 | ACOT1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-07 | 1.63e-01 | -0.1001 |
641371 | ACOT1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.07e-10 | 2.96e-01 | -0.059 |
641371 | ACOT1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.31e-03 | 2.57e-01 | -0.2061 |
641371 | ACOT1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.25e-04 | 2.59e-01 | -0.0842 |
641371 | ACOT1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.55e-03 | 1.64e-01 | 0.096 |
641371 | ACOT1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.03e-02 | 2.05e-01 | -0.0177 |
641371 | ACOT1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.00e-05 | 1.54e-01 | 0.0674 |
641371 | ACOT1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.29e-02 | 2.72e-01 | 0.0112 |
641371 | ACOT1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.17e-05 | 1.85e-01 | 0.294 |
641371 | ACOT1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.16e-05 | 2.55e-01 | 0.281 |
641371 | ACOT1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.62e-04 | 1.11e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:01201613 | Liver | NAFLD | regulation of cold-induced thermogenesis | 25/1882 | 144/18723 | 4.66e-03 | 3.74e-02 | 25 |
GO:000663112 | Liver | Cirrhotic | fatty acid metabolic process | 165/4634 | 390/18723 | 1.29e-14 | 1.26e-12 | 165 |
GO:000675312 | Liver | Cirrhotic | nucleoside phosphate metabolic process | 190/4634 | 497/18723 | 1.10e-11 | 6.96e-10 | 190 |
GO:000911712 | Liver | Cirrhotic | nucleotide metabolic process | 187/4634 | 489/18723 | 1.55e-11 | 9.63e-10 | 187 |
GO:001969312 | Liver | Cirrhotic | ribose phosphate metabolic process | 156/4634 | 396/18723 | 5.83e-11 | 3.23e-09 | 156 |
GO:000925912 | Liver | Cirrhotic | ribonucleotide metabolic process | 151/4634 | 385/18723 | 1.72e-10 | 8.70e-09 | 151 |
GO:007252112 | Liver | Cirrhotic | purine-containing compound metabolic process | 156/4634 | 416/18723 | 3.74e-09 | 1.52e-07 | 156 |
GO:000915012 | Liver | Cirrhotic | purine ribonucleotide metabolic process | 141/4634 | 368/18723 | 4.22e-09 | 1.70e-07 | 141 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:000616312 | Liver | Cirrhotic | purine nucleotide metabolic process | 146/4634 | 396/18723 | 4.12e-08 | 1.34e-06 | 146 |
GO:0006084 | Liver | Cirrhotic | acetyl-CoA metabolic process | 19/4634 | 35/18723 | 1.70e-04 | 1.60e-03 | 19 |
GO:00338651 | Liver | Cirrhotic | nucleoside bisphosphate metabolic process | 50/4634 | 128/18723 | 2.32e-04 | 2.11e-03 | 50 |
GO:00338751 | Liver | Cirrhotic | ribonucleoside bisphosphate metabolic process | 50/4634 | 128/18723 | 2.32e-04 | 2.11e-03 | 50 |
GO:00340321 | Liver | Cirrhotic | purine nucleoside bisphosphate metabolic process | 50/4634 | 128/18723 | 2.32e-04 | 2.11e-03 | 50 |
GO:00066371 | Liver | Cirrhotic | acyl-CoA metabolic process | 38/4634 | 96/18723 | 9.23e-04 | 6.57e-03 | 38 |
GO:00353831 | Liver | Cirrhotic | thioester metabolic process | 38/4634 | 96/18723 | 9.23e-04 | 6.57e-03 | 38 |
GO:000911722 | Liver | HCC | nucleotide metabolic process | 300/7958 | 489/18723 | 1.61e-17 | 1.71e-15 | 300 |
GO:000675322 | Liver | HCC | nucleoside phosphate metabolic process | 304/7958 | 497/18723 | 1.78e-17 | 1.85e-15 | 304 |
GO:001969322 | Liver | HCC | ribose phosphate metabolic process | 248/7958 | 396/18723 | 3.15e-16 | 2.70e-14 | 248 |
GO:000925922 | Liver | HCC | ribonucleotide metabolic process | 240/7958 | 385/18723 | 2.07e-15 | 1.51e-13 | 240 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00062 | Colorectum | SER | Fatty acid elongation | 11/1580 | 27/8465 | 6.38e-03 | 3.68e-02 | 2.67e-02 | 11 |
hsa000621 | Colorectum | SER | Fatty acid elongation | 11/1580 | 27/8465 | 6.38e-03 | 3.68e-02 | 2.67e-02 | 11 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ACOT1 | SNV | Missense_Mutation | novel | c.1009G>A | p.Glu337Lys | p.E337K | Q86TX2 | protein_coding | tolerated(0.51) | benign(0.028) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
ACOT1 | SNV | Missense_Mutation | rs778993401 | c.46N>A | p.Asp16Asn | p.D16N | Q86TX2 | protein_coding | deleterious(0.03) | probably_damaging(0.915) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
ACOT1 | SNV | Missense_Mutation | c.689N>A | p.Gly230Glu | p.G230E | Q86TX2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ACOT1 | SNV | Missense_Mutation | novel | c.261N>T | p.Glu87Asp | p.E87D | Q86TX2 | protein_coding | tolerated(0.55) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ACOT1 | SNV | Missense_Mutation | c.539N>T | p.Gly180Val | p.G180V | Q86TX2 | protein_coding | deleterious(0) | possibly_damaging(0.783) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
ACOT1 | SNV | Missense_Mutation | rs757997047 | c.766G>A | p.Gly256Ser | p.G256S | Q86TX2 | protein_coding | tolerated(0.07) | possibly_damaging(0.893) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACOT1 | SNV | Missense_Mutation | novel | c.1204C>T | p.Leu402Phe | p.L402F | Q86TX2 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACOT1 | SNV | Missense_Mutation | rs753448518 | c.757G>A | p.Val253Ile | p.V253I | Q86TX2 | protein_coding | tolerated(0.59) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACOT1 | SNV | Missense_Mutation | novel | c.999C>A | p.Phe333Leu | p.F333L | Q86TX2 | protein_coding | tolerated(0.69) | benign(0.018) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ACOT1 | SNV | Missense_Mutation | novel | c.781N>A | p.Val261Ile | p.V261I | Q86TX2 | protein_coding | tolerated(0.19) | benign(0.01) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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