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Gene: ABHD3 |
Gene summary for ABHD3 |
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Gene information | Species | Human | Gene symbol | ABHD3 | Gene ID | 171586 |
Gene name | abhydrolase domain containing 3, phospholipase | |
Gene Alias | LABH3 | |
Cytomap | 18q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | J3KTE1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
171586 | ABHD3 | CCI_1 | Human | Cervix | CC | 4.92e-05 | 9.10e-01 | 0.528 |
171586 | ABHD3 | CCI_3 | Human | Cervix | CC | 1.76e-05 | 6.00e-01 | 0.516 |
171586 | ABHD3 | T1 | Human | Cervix | CC | 1.06e-05 | 3.96e-01 | 0.0918 |
171586 | ABHD3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.73e-04 | 4.19e-01 | -0.1808 |
171586 | ABHD3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.06e-04 | 6.12e-01 | -0.0811 |
171586 | ABHD3 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.19e-10 | 4.92e-01 | -0.1954 |
171586 | ABHD3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-03 | 9.44e-01 | -0.2602 |
171586 | ABHD3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.80e-02 | 4.38e-01 | -0.059 |
171586 | ABHD3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.54e-11 | -5.00e-01 | 0.3859 |
171586 | ABHD3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.21e-15 | -5.42e-01 | 0.3005 |
171586 | ABHD3 | A002-C-010 | Human | Colorectum | FAP | 1.30e-03 | 2.50e-01 | 0.242 |
171586 | ABHD3 | A015-C-203 | Human | Colorectum | FAP | 1.09e-15 | -3.32e-01 | -0.1294 |
171586 | ABHD3 | A015-C-204 | Human | Colorectum | FAP | 1.54e-02 | -2.89e-01 | -0.0228 |
171586 | ABHD3 | A002-C-201 | Human | Colorectum | FAP | 2.46e-05 | -1.90e-01 | 0.0324 |
171586 | ABHD3 | A001-C-119 | Human | Colorectum | FAP | 6.01e-07 | -4.83e-01 | -0.1557 |
171586 | ABHD3 | A001-C-108 | Human | Colorectum | FAP | 3.70e-10 | -2.52e-01 | -0.0272 |
171586 | ABHD3 | A002-C-205 | Human | Colorectum | FAP | 1.41e-13 | -4.72e-01 | -0.1236 |
171586 | ABHD3 | A015-C-006 | Human | Colorectum | FAP | 9.81e-11 | -5.49e-01 | -0.0994 |
171586 | ABHD3 | A015-C-106 | Human | Colorectum | FAP | 2.10e-06 | -2.82e-01 | -0.0511 |
171586 | ABHD3 | A002-C-114 | Human | Colorectum | FAP | 3.40e-08 | -3.20e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00450174 | Liver | NAFLD | glycerolipid biosynthetic process | 43/1882 | 252/18723 | 3.83e-04 | 5.73e-03 | 43 |
GO:00066334 | Liver | NAFLD | fatty acid biosynthetic process | 29/1882 | 163/18723 | 1.67e-03 | 1.74e-02 | 29 |
GO:0006656 | Liver | NAFLD | phosphatidylcholine biosynthetic process | 8/1882 | 29/18723 | 6.40e-03 | 4.69e-02 | 8 |
GO:00464742 | Liver | NAFLD | glycerophospholipid biosynthetic process | 33/1882 | 211/18723 | 6.93e-03 | 4.88e-02 | 33 |
GO:000663112 | Liver | Cirrhotic | fatty acid metabolic process | 165/4634 | 390/18723 | 1.29e-14 | 1.26e-12 | 165 |
GO:001605312 | Liver | Cirrhotic | organic acid biosynthetic process | 139/4634 | 316/18723 | 4.28e-14 | 3.83e-12 | 139 |
GO:004639412 | Liver | Cirrhotic | carboxylic acid biosynthetic process | 137/4634 | 314/18723 | 1.40e-13 | 1.14e-11 | 137 |
GO:004428211 | Liver | Cirrhotic | small molecule catabolic process | 151/4634 | 376/18723 | 2.20e-11 | 1.34e-09 | 151 |
GO:001605411 | Liver | Cirrhotic | organic acid catabolic process | 104/4634 | 240/18723 | 1.91e-10 | 9.53e-09 | 104 |
GO:004639511 | Liver | Cirrhotic | carboxylic acid catabolic process | 102/4634 | 236/18723 | 3.41e-10 | 1.63e-08 | 102 |
GO:007233011 | Liver | Cirrhotic | monocarboxylic acid biosynthetic process | 93/4634 | 214/18723 | 1.43e-09 | 6.16e-08 | 93 |
GO:000663311 | Liver | Cirrhotic | fatty acid biosynthetic process | 70/4634 | 163/18723 | 2.57e-07 | 6.41e-06 | 70 |
GO:007232911 | Liver | Cirrhotic | monocarboxylic acid catabolic process | 56/4634 | 122/18723 | 2.87e-07 | 7.01e-06 | 56 |
GO:000906211 | Liver | Cirrhotic | fatty acid catabolic process | 48/4634 | 100/18723 | 3.87e-07 | 9.13e-06 | 48 |
GO:004424212 | Liver | Cirrhotic | cellular lipid catabolic process | 82/4634 | 214/18723 | 6.91e-06 | 1.08e-04 | 82 |
GO:001604212 | Liver | Cirrhotic | lipid catabolic process | 112/4634 | 320/18723 | 2.31e-05 | 3.03e-04 | 112 |
GO:001605321 | Liver | HCC | organic acid biosynthetic process | 200/7958 | 316/18723 | 5.24e-14 | 3.22e-12 | 200 |
GO:000663122 | Liver | HCC | fatty acid metabolic process | 238/7958 | 390/18723 | 8.24e-14 | 4.84e-12 | 238 |
GO:004639421 | Liver | HCC | carboxylic acid biosynthetic process | 198/7958 | 314/18723 | 1.19e-13 | 6.78e-12 | 198 |
GO:004428221 | Liver | HCC | small molecule catabolic process | 225/7958 | 376/18723 | 6.50e-12 | 2.80e-10 | 225 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ABHD3 | SNV | Missense_Mutation | c.926N>T | p.Thr309Ile | p.T309I | Q8WU67 | protein_coding | deleterious(0.04) | possibly_damaging(0.702) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
ABHD3 | SNV | Missense_Mutation | c.189N>T | p.Glu63Asp | p.E63D | Q8WU67 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ABHD3 | SNV | Missense_Mutation | c.74N>A | p.Val25Glu | p.V25E | Q8WU67 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-AF-A56L-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
ABHD3 | SNV | Missense_Mutation | c.1073C>T | p.Thr358Ile | p.T358I | Q8WU67 | protein_coding | tolerated(0.12) | benign(0.021) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ABHD3 | SNV | Missense_Mutation | c.469A>C | p.Ile157Leu | p.I157L | Q8WU67 | protein_coding | deleterious(0.02) | possibly_damaging(0.53) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ABHD3 | SNV | Missense_Mutation | novel | c.448N>A | p.Gly150Arg | p.G150R | Q8WU67 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABHD3 | SNV | Missense_Mutation | novel | c.448N>A | p.Gly150Arg | p.G150R | Q8WU67 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ABHD3 | SNV | Missense_Mutation | novel | c.662N>C | p.Met221Thr | p.M221T | Q8WU67 | protein_coding | deleterious(0) | possibly_damaging(0.864) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ABHD3 | SNV | Missense_Mutation | c.842N>G | p.Lys281Arg | p.K281R | Q8WU67 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ABHD3 | SNV | Missense_Mutation | novel | c.223N>A | p.Val75Met | p.V75M | Q8WU67 | protein_coding | deleterious(0.03) | benign(0.371) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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