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Gene: TRIM2 |
Gene summary for TRIM2 |
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Gene information | Species | Human | Gene symbol | TRIM2 | Gene ID | 23321 |
Gene name | tripartite motif containing 2 | |
Gene Alias | CMT2R | |
Cytomap | 4q31.3 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9C040 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23321 | TRIM2 | CA_HPV_1 | Human | Cervix | CC | 8.99e-09 | -2.78e-01 | 0.0264 |
23321 | TRIM2 | CA_HPV_3 | Human | Cervix | CC | 2.44e-02 | -2.31e-01 | 0.0414 |
23321 | TRIM2 | N_HPV_1 | Human | Cervix | N_HPV | 4.34e-05 | -2.58e-01 | 0.0079 |
23321 | TRIM2 | N_HPV_2 | Human | Cervix | N_HPV | 1.34e-02 | -2.46e-01 | -0.0131 |
23321 | TRIM2 | CCI_1 | Human | Cervix | CC | 4.97e-02 | 6.42e-01 | 0.528 |
23321 | TRIM2 | CCI_2 | Human | Cervix | CC | 9.64e-04 | 7.16e-01 | 0.5249 |
23321 | TRIM2 | H2 | Human | Cervix | HSIL_HPV | 5.94e-07 | 3.49e-01 | 0.0632 |
23321 | TRIM2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.73e-08 | -4.24e-01 | 0.0155 |
23321 | TRIM2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.80e-19 | 8.02e-01 | -0.1954 |
23321 | TRIM2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.76e-03 | -5.61e-01 | -0.1207 |
23321 | TRIM2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.58e-05 | -5.05e-01 | 0.0528 |
23321 | TRIM2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.56e-02 | -2.87e-01 | 0.294 |
23321 | TRIM2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.94e-08 | 6.73e-01 | 0.281 |
23321 | TRIM2 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.14e-05 | -4.08e-01 | 0.3005 |
23321 | TRIM2 | A002-C-010 | Human | Colorectum | FAP | 1.57e-05 | 1.49e-01 | 0.242 |
23321 | TRIM2 | A015-C-203 | Human | Colorectum | FAP | 9.78e-29 | -2.81e-01 | -0.1294 |
23321 | TRIM2 | A014-C-040 | Human | Colorectum | FAP | 2.14e-02 | -2.98e-01 | -0.1184 |
23321 | TRIM2 | A002-C-201 | Human | Colorectum | FAP | 1.50e-08 | -2.20e-01 | 0.0324 |
23321 | TRIM2 | A001-C-119 | Human | Colorectum | FAP | 4.63e-10 | 2.65e-01 | -0.1557 |
23321 | TRIM2 | A001-C-108 | Human | Colorectum | FAP | 3.99e-13 | -1.20e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007233113 | Lung | AIS | signal transduction by p53 class mediator | 44/1849 | 163/18723 | 3.66e-10 | 8.87e-08 | 44 |
GO:001905813 | Lung | AIS | viral life cycle | 68/1849 | 317/18723 | 5.39e-10 | 1.16e-07 | 68 |
GO:003164713 | Lung | AIS | regulation of protein stability | 62/1849 | 298/18723 | 1.06e-08 | 1.63e-06 | 62 |
GO:004671813 | Lung | AIS | viral entry into host cell | 38/1849 | 144/18723 | 1.13e-08 | 1.68e-06 | 38 |
GO:005212613 | Lung | AIS | movement in host environment | 43/1849 | 175/18723 | 1.29e-08 | 1.88e-06 | 43 |
GO:005170113 | Lung | AIS | biological process involved in interaction with host | 47/1849 | 203/18723 | 2.09e-08 | 2.90e-06 | 47 |
GO:004316113 | Lung | AIS | proteasome-mediated ubiquitin-dependent protein catabolic process | 77/1849 | 412/18723 | 2.74e-08 | 3.47e-06 | 77 |
GO:001049813 | Lung | AIS | proteasomal protein catabolic process | 87/1849 | 490/18723 | 4.15e-08 | 5.03e-06 | 87 |
GO:004440913 | Lung | AIS | entry into host | 38/1849 | 151/18723 | 4.50e-08 | 5.24e-06 | 38 |
GO:004440313 | Lung | AIS | biological process involved in symbiotic interaction | 58/1849 | 290/18723 | 1.33e-07 | 1.44e-05 | 58 |
GO:190179613 | Lung | AIS | regulation of signal transduction by p53 class mediator | 27/1849 | 93/18723 | 1.78e-07 | 1.76e-05 | 27 |
GO:000020912 | Lung | AIS | protein polyubiquitination | 49/1849 | 236/18723 | 3.85e-07 | 3.16e-05 | 49 |
GO:003052213 | Lung | AIS | intracellular receptor signaling pathway | 53/1849 | 265/18723 | 4.57e-07 | 3.55e-05 | 53 |
GO:005079213 | Lung | AIS | regulation of viral process | 32/1849 | 164/18723 | 1.33e-04 | 2.97e-03 | 32 |
GO:007099713 | Lung | AIS | neuron death | 58/1849 | 361/18723 | 1.39e-04 | 3.05e-03 | 58 |
GO:004677711 | Lung | AIS | protein autophosphorylation | 39/1849 | 227/18723 | 4.30e-04 | 7.37e-03 | 39 |
GO:003166813 | Lung | AIS | cellular response to extracellular stimulus | 41/1849 | 246/18723 | 5.90e-04 | 9.03e-03 | 41 |
GO:190121413 | Lung | AIS | regulation of neuron death | 50/1849 | 319/18723 | 6.90e-04 | 1.02e-02 | 50 |
GO:007149613 | Lung | AIS | cellular response to external stimulus | 50/1849 | 320/18723 | 7.41e-04 | 1.07e-02 | 50 |
GO:005109011 | Lung | AIS | regulation of DNA-binding transcription factor activity | 64/1849 | 440/18723 | 1.04e-03 | 1.36e-02 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIM2 | SNV | Missense_Mutation | novel | c.1667N>T | p.Ser556Phe | p.S556F | Q9C040 | protein_coding | deleterious(0) | benign(0.352) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TRIM2 | SNV | Missense_Mutation | novel | c.230A>G | p.Tyr77Cys | p.Y77C | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A7VC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM2 | SNV | Missense_Mutation | rs780090814 | c.1793G>T | p.Gly598Val | p.G598V | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR |
TRIM2 | insertion | Frame_Shift_Ins | novel | c.211_212insCTCACCCAGGCTGGAGTGC | p.Glu71AlafsTer62 | p.E71Afs*62 | Q9C040 | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
TRIM2 | deletion | Frame_Shift_Del | novel | c.1234delN | p.Lys412ArgfsTer21 | p.K412Rfs*21 | Q9C040 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
TRIM2 | SNV | Missense_Mutation | rs759524701 | c.1876G>A | p.Val626Met | p.V626M | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRIM2 | SNV | Missense_Mutation | rs754843842 | c.733N>T | p.Arg245Cys | p.R245C | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM2 | SNV | Missense_Mutation | novel | c.1724N>A | p.Ile575Asn | p.I575N | Q9C040 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3979-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRIM2 | SNV | Missense_Mutation | novel | c.225N>T | p.Gln75His | p.Q75H | Q9C040 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRIM2 | SNV | Missense_Mutation | novel | c.1183N>A | p.Glu395Lys | p.E395K | Q9C040 | protein_coding | tolerated(0.23) | benign(0.253) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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