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Gene: RPL11 |
Gene summary for RPL11 |
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Gene information | Species | Human | Gene symbol | RPL11 | Gene ID | 6135 |
Gene name | ribosomal protein L11 | |
Gene Alias | DBA7 | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0000027 | UniProtAcc | P62913 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6135 | RPL11 | CA_HPV_1 | Human | Cervix | CC | 4.23e-06 | -1.71e-01 | 0.0264 |
6135 | RPL11 | CA_HPV_2 | Human | Cervix | CC | 3.55e-20 | -2.45e-01 | 0.0391 |
6135 | RPL11 | CCI_1 | Human | Cervix | CC | 2.52e-76 | -2.06e+00 | 0.528 |
6135 | RPL11 | CCI_2 | Human | Cervix | CC | 1.16e-77 | -1.96e+00 | 0.5249 |
6135 | RPL11 | CCI_3 | Human | Cervix | CC | 4.16e-94 | -2.02e+00 | 0.516 |
6135 | RPL11 | CCII_1 | Human | Cervix | CC | 2.73e-96 | -2.17e+00 | 0.3249 |
6135 | RPL11 | Tumor | Human | Cervix | CC | 1.13e-62 | -3.31e-01 | 0.1241 |
6135 | RPL11 | sample1 | Human | Cervix | CC | 2.05e-16 | -3.06e-01 | 0.0959 |
6135 | RPL11 | sample3 | Human | Cervix | CC | 3.36e-93 | -4.19e-01 | 0.1387 |
6135 | RPL11 | H2 | Human | Cervix | HSIL_HPV | 1.37e-52 | -3.66e-01 | 0.0632 |
6135 | RPL11 | L1 | Human | Cervix | CC | 3.45e-07 | -2.15e-01 | 0.0802 |
6135 | RPL11 | T1 | Human | Cervix | CC | 5.81e-49 | -4.14e-01 | 0.0918 |
6135 | RPL11 | T2 | Human | Cervix | CC | 8.24e-03 | -1.57e-01 | 0.0709 |
6135 | RPL11 | T3 | Human | Cervix | CC | 5.25e-94 | -4.17e-01 | 0.1389 |
6135 | RPL11 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.63e-119 | 2.51e+00 | 0.0155 |
6135 | RPL11 | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.89e-66 | 2.67e+00 | -0.1808 |
6135 | RPL11 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.54e-29 | 2.58e+00 | 0.0216 |
6135 | RPL11 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.06e-65 | 2.70e+00 | -0.0811 |
6135 | RPL11 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.08e-45 | 1.80e+00 | -0.1088 |
6135 | RPL11 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.56e-103 | 2.93e+00 | -0.1954 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004225413 | Lung | MIAC | ribosome biogenesis | 33/967 | 299/18723 | 3.37e-05 | 1.92e-03 | 33 |
GO:002261323 | Lung | MIAC | ribonucleoprotein complex biogenesis | 44/967 | 463/18723 | 7.38e-05 | 3.47e-03 | 44 |
GO:190225323 | Lung | MIAC | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 8/967 | 29/18723 | 7.99e-05 | 3.66e-03 | 8 |
GO:003139623 | Lung | MIAC | regulation of protein ubiquitination | 25/967 | 210/18723 | 8.79e-05 | 3.92e-03 | 25 |
GO:005082123 | Lung | MIAC | protein stabilization | 23/967 | 191/18723 | 1.40e-04 | 5.55e-03 | 23 |
GO:003133033 | Lung | MIAC | negative regulation of cellular catabolic process | 28/967 | 262/18723 | 2.23e-04 | 7.67e-03 | 28 |
GO:009719333 | Lung | MIAC | intrinsic apoptotic signaling pathway | 29/967 | 288/18723 | 4.72e-04 | 1.29e-02 | 29 |
GO:003243432 | Lung | MIAC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 17/967 | 134/18723 | 5.45e-04 | 1.40e-02 | 17 |
GO:006113623 | Lung | MIAC | regulation of proteasomal protein catabolic process | 21/967 | 187/18723 | 6.85e-04 | 1.59e-02 | 21 |
GO:004316123 | Lung | MIAC | proteasome-mediated ubiquitin-dependent protein catabolic process | 37/967 | 412/18723 | 7.87e-04 | 1.76e-02 | 37 |
GO:000636413 | Lung | MIAC | rRNA processing | 23/967 | 225/18723 | 1.43e-03 | 2.54e-02 | 23 |
GO:005143832 | Lung | MIAC | regulation of ubiquitin-protein transferase activity | 9/967 | 53/18723 | 1.44e-03 | 2.54e-02 | 9 |
GO:005134832 | Lung | MIAC | negative regulation of transferase activity | 26/967 | 268/18723 | 1.55e-03 | 2.65e-02 | 26 |
GO:190336322 | Lung | MIAC | negative regulation of cellular protein catabolic process | 11/967 | 75/18723 | 1.56e-03 | 2.65e-02 | 11 |
GO:200124223 | Lung | MIAC | regulation of intrinsic apoptotic signaling pathway | 18/967 | 164/18723 | 2.07e-03 | 3.26e-02 | 18 |
GO:000989523 | Lung | MIAC | negative regulation of catabolic process | 29/967 | 320/18723 | 2.42e-03 | 3.56e-02 | 29 |
GO:001607213 | Lung | MIAC | rRNA metabolic process | 23/967 | 236/18723 | 2.65e-03 | 3.71e-02 | 23 |
GO:001049823 | Lung | MIAC | proteasomal protein catabolic process | 40/967 | 490/18723 | 2.92e-03 | 3.99e-02 | 40 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa05171 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa030101 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa051711 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa030102 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa051712 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
hsa030103 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa051713 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
hsa030104 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa051714 | Colorectum | MSS | Coronavirus disease - COVID-19 | 108/1875 | 232/8465 | 6.50e-17 | 1.67e-15 | 1.03e-15 | 108 |
hsa030105 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa051715 | Colorectum | MSS | Coronavirus disease - COVID-19 | 108/1875 | 232/8465 | 6.50e-17 | 1.67e-15 | 1.03e-15 | 108 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL11 | deletion | Frame_Shift_Del | novel | c.516delG | p.Ile173SerfsTer21 | p.I173Sfs*21 | P62913 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
RPL11 | SNV | Missense_Mutation | c.424G>A | p.Ala142Thr | p.A142T | P62913 | protein_coding | tolerated(0.19) | benign(0.031) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RPL11 | SNV | Missense_Mutation | novel | c.496T>C | p.Phe166Leu | p.F166L | P62913 | protein_coding | tolerated(0.14) | benign(0.075) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RPL11 | SNV | Missense_Mutation | novel | c.386N>T | p.Asp129Val | p.D129V | P62913 | protein_coding | deleterious(0) | probably_damaging(0.939) | TCGA-F5-6812-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RPL11 | SNV | Missense_Mutation | novel | c.515N>A | p.Gly172Glu | p.G172E | P62913 | protein_coding | deleterious(0) | possibly_damaging(0.764) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL11 | SNV | Missense_Mutation | novel | c.413N>A | p.Gly138Asp | p.G138D | P62913 | protein_coding | deleterious(0.03) | possibly_damaging(0.539) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL11 | SNV | Missense_Mutation | novel | c.365N>T | p.Ser122Ile | p.S122I | P62913 | protein_coding | deleterious(0.02) | benign(0.213) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RPL11 | SNV | Missense_Mutation | rs770776620 | c.437N>A | p.Arg146His | p.R146H | P62913 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
RPL11 | SNV | Missense_Mutation | novel | c.47G>A | p.Arg16His | p.R16H | P62913 | protein_coding | tolerated(0.2) | benign(0.052) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
RPL11 | SNV | Missense_Mutation | novel | c.235N>A | p.Ala79Thr | p.A79T | P62913 | protein_coding | deleterious(0.01) | possibly_damaging(0.451) | TCGA-AX-A2H7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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