Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PRKCE

Gene summary for PRKCE

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PRKCE

Gene ID

5581

Gene nameprotein kinase C epsilon
Gene AliasPKCE
Cytomap2p21
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

L7RTI5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
5581PRKCECCI_1HumanCervixCC9.93e-161.24e+000.528
5581PRKCECCI_2HumanCervixCC5.53e-121.03e+000.5249
5581PRKCECCI_3HumanCervixCC2.32e-107.08e-010.516
5581PRKCEHTA11_3410_2000001011HumanColorectumAD2.07e-11-5.48e-010.0155
5581PRKCEHTA11_347_2000001011HumanColorectumAD1.24e-075.48e-01-0.1954
5581PRKCEHTA11_99999970781_79442HumanColorectumMSS1.03e-26-7.05e-010.294
5581PRKCEHTA11_99999971662_82457HumanColorectumMSS2.82e-04-3.43e-010.3859
5581PRKCEA001-C-207HumanColorectumFAP2.46e-04-3.66e-010.1278
5581PRKCEA015-C-203HumanColorectumFAP1.04e-33-3.98e-01-0.1294
5581PRKCEA015-C-204HumanColorectumFAP6.86e-05-3.49e-01-0.0228
5581PRKCEA014-C-040HumanColorectumFAP3.95e-03-2.84e-01-0.1184
5581PRKCEA002-C-201HumanColorectumFAP9.45e-11-2.08e-010.0324
5581PRKCEA001-C-119HumanColorectumFAP4.01e-10-6.88e-01-0.1557
5581PRKCEA001-C-108HumanColorectumFAP9.71e-22-4.77e-01-0.0272
5581PRKCEA002-C-205HumanColorectumFAP1.14e-21-4.04e-01-0.1236
5581PRKCEA001-C-104HumanColorectumFAP9.84e-08-4.17e-010.0184
5581PRKCEA015-C-006HumanColorectumFAP2.32e-19-7.23e-01-0.0994
5581PRKCEA015-C-106HumanColorectumFAP2.11e-13-3.55e-01-0.0511
5581PRKCEA002-C-114HumanColorectumFAP5.73e-18-4.02e-01-0.1561
5581PRKCEA015-C-104HumanColorectumFAP4.94e-39-6.15e-01-0.1899
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:004312218Oral cavityOSCCregulation of I-kappaB kinase/NF-kappaB signaling155/7305249/187237.79e-144.14e-12155
GO:004312310Oral cavityOSCCpositive regulation of I-kappaB kinase/NF-kappaB signaling122/7305186/187231.68e-138.52e-12122
GO:004206020Oral cavityOSCCwound healing237/7305422/187234.51e-132.18e-11237
GO:000724910Oral cavityOSCCI-kappaB kinase/NF-kappaB signaling169/7305281/187234.69e-132.25e-11169
GO:007048219Oral cavityOSCCresponse to oxygen levels200/7305347/187231.17e-125.13e-11200
GO:007265918Oral cavityOSCCprotein localization to plasma membrane169/7305284/187231.69e-127.21e-11169
GO:190290520Oral cavityOSCCpositive regulation of supramolecular fiber organization131/7305209/187233.18e-121.27e-10131
GO:199077816Oral cavityOSCCprotein localization to cell periphery190/7305333/187231.46e-115.13e-10190
GO:000166619Oral cavityOSCCresponse to hypoxia177/7305307/187232.21e-117.50e-10177
GO:190290320Oral cavityOSCCregulation of supramolecular fiber organization211/7305383/187239.45e-112.88e-09211
GO:003629319Oral cavityOSCCresponse to decreased oxygen levels182/7305322/187231.14e-103.41e-09182
GO:003139720Oral cavityOSCCnegative regulation of protein ubiquitination61/730583/187231.78e-105.17e-0961
GO:005149518Oral cavityOSCCpositive regulation of cytoskeleton organization135/7305226/187231.98e-105.66e-09135
GO:005125820Oral cavityOSCCprotein polymerization169/7305297/187232.57e-107.17e-09169
GO:005123518Oral cavityOSCCmaintenance of location182/7305327/187236.16e-101.58e-08182
GO:003227319Oral cavityOSCCpositive regulation of protein polymerization88/7305138/187233.24e-097.39e-0888
GO:00457879Oral cavityOSCCpositive regulation of cell cycle173/7305313/187233.28e-097.44e-08173
GO:190332120Oral cavityOSCCnegative regulation of protein modification by small protein conjugation or removal65/730595/187235.88e-091.26e-0765
GO:003227120Oral cavityOSCCregulation of protein polymerization134/7305233/187237.20e-091.51e-07134
GO:000701520Oral cavityOSCCactin filament organization230/7305442/187231.37e-082.77e-07230
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0513120CervixCCShigellosis69/1267247/84657.64e-081.03e-066.10e-0769
hsa0453020CervixCCTight junction49/1267169/84651.87e-061.78e-051.05e-0549
hsa0466612CervixCCFc gamma R-mediated phagocytosis31/126797/84651.78e-051.42e-048.40e-0531
hsa0407110CervixCCSphingolipid signaling pathway35/1267121/84655.70e-053.93e-042.32e-0435
hsa049336CervixCCAGE-RAGE signaling pathway in diabetic complications25/1267100/84655.64e-031.88e-021.11e-0225
hsa05131110CervixCCShigellosis69/1267247/84657.64e-081.03e-066.10e-0769
hsa04530110CervixCCTight junction49/1267169/84651.87e-061.78e-051.05e-0549
hsa0466613CervixCCFc gamma R-mediated phagocytosis31/126797/84651.78e-051.42e-048.40e-0531
hsa0407113CervixCCSphingolipid signaling pathway35/1267121/84655.70e-053.93e-042.32e-0435
hsa0493313CervixCCAGE-RAGE signaling pathway in diabetic complications25/1267100/84655.64e-031.88e-021.11e-0225
hsa05131ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa04530ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa04666ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa04071ColorectumADSphingolipid signaling pathway43/2092121/84654.83e-032.28e-021.45e-0243
hsa051311ColorectumADShigellosis109/2092247/84651.09e-112.44e-101.55e-10109
hsa045301ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa046661ColorectumADFc gamma R-mediated phagocytosis46/209297/84659.10e-071.22e-057.77e-0646
hsa040711ColorectumADSphingolipid signaling pathway43/2092121/84654.83e-032.28e-021.45e-0243
hsa051314ColorectumMSSShigellosis94/1875247/84656.82e-091.34e-078.23e-0894
hsa046664ColorectumMSSFc gamma R-mediated phagocytosis45/187597/84659.30e-081.56e-069.55e-0745
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PRKCESNVMissense_Mutationnovelc.256G>Ap.Asp86Asnp.D86NQ02156protein_codingtolerated(0.07)benign(0.36)TCGA-3C-AALI-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificPoly EComplete Response
PRKCESNVMissense_Mutationnovelc.404C>Tp.Ser135Leup.S135LQ02156protein_codingtolerated(0.28)benign(0.006)TCGA-A7-A13F-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinSD
PRKCESNVMissense_Mutationnovelc.1219N>Ap.Glu407Lysp.E407KQ02156protein_codingdeleterious(0)benign(0.017)TCGA-AC-A6IW-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PRKCESNVMissense_Mutationc.1441N>Ap.Arg481Serp.R481SQ02156protein_codingdeleterious(0)probably_damaging(1)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PRKCESNVMissense_Mutationnovelc.634N>Cp.Cys212Argp.C212RQ02156protein_codingdeleterious(0)probably_damaging(1)TCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
PRKCESNVMissense_Mutationc.202N>Ap.Glu68Lysp.E68KQ02156protein_codingtolerated(0.19)benign(0.022)TCGA-C8-A137-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
PRKCESNVMissense_Mutationnovelc.79N>Tp.His27Tyrp.H27YQ02156protein_codingdeleterious(0.03)possibly_damaging(0.898)TCGA-E2-A2P6-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
PRKCEinsertionNonsense_Mutationnovelc.2059_2060insACCTCGTAGGGCATTAGGATGAAATGAGTTGATAp.Pro687HisfsTer6p.P687Hfs*6Q02156protein_codingTCGA-A8-A09C-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PRKCEinsertionFrame_Shift_Insnovelc.460_461insTAACCAACAGACATTCACTTCTCACAGTTTTp.Arg154IlefsTer131p.R154Ifs*131Q02156protein_codingTCGA-AN-A03X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PRKCEinsertionIn_Frame_Insnovelc.2056_2057insTCTTCATTGGTTCTGCCTCTACTTACACTTTGGAGCTGCp.Lys686delinsIlePheIleGlySerAlaSerThrTyrThrLeuGluLeuGlnp.K686delinsIFIGSASTYTLELQQ02156protein_codingTCGA-BH-A0HF-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYMEPHORBOL MYRISTATE ACETATEPHORBOL MYRISTATE ACETATE22579485
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYMEINGENOL MEBUTATE
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYME[3H]-PHORBOL 12,13-DIBUTYRATECHEMBL2776824794745
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYMEKAI-1455
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYMEinhibitorCHEMBL608533MIDOSTAURIN
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYMEinhibitor249565629SOTRASTAURIN
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYMEinhibitor178102576CHELERYTHRINE
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYMEinhibitorCHEMBL3545332CEP-2563
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYMEBRYOSTATINBRYOSTATIN
5581PRKCESERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ION CHANNEL, TRANSCRIPTION FACTOR, ENZYMEradiotherapy25054431
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