Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/CIRBP_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/CIRBP_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CIRBP_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CIRBP_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CIRBP_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CIRBP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/CIRBP_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CIRBP_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CIRBP_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CIRBP_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CIRBP_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CIRBP_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CIRBP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00480246 | Stomach | CAG with IM | regulation of mRNA splicing, via spliceosome | 13/1050 | 101/18723 | 4.19e-03 | 3.57e-02 | 13 |
GO:00003756 | Stomach | CAG with IM | RNA splicing, via transesterification reactions | 30/1050 | 324/18723 | 4.95e-03 | 4.01e-02 | 30 |
GO:19033126 | Stomach | CAG with IM | negative regulation of mRNA metabolic process | 12/1050 | 92/18723 | 5.23e-03 | 4.19e-02 | 12 |
GO:004572721 | Stomach | CSG | positive regulation of translation | 22/1034 | 136/18723 | 5.27e-06 | 2.03e-04 | 22 |
GO:00092662 | Stomach | CSG | response to temperature stimulus | 25/1034 | 178/18723 | 1.62e-05 | 5.06e-04 | 25 |
GO:003425021 | Stomach | CSG | positive regulation of cellular amide metabolic process | 23/1034 | 162/18723 | 2.92e-05 | 8.26e-04 | 23 |
GO:000940921 | Stomach | CSG | response to cold | 10/1034 | 49/18723 | 2.89e-04 | 5.07e-03 | 10 |
GO:003133021 | Stomach | CSG | negative regulation of cellular catabolic process | 29/1034 | 262/18723 | 2.92e-04 | 5.07e-03 | 29 |
GO:00093142 | Stomach | CSG | response to radiation | 43/1034 | 456/18723 | 4.45e-04 | 6.98e-03 | 43 |
GO:000641721 | Stomach | CSG | regulation of translation | 43/1034 | 468/18723 | 7.58e-04 | 1.04e-02 | 43 |
GO:004802621 | Stomach | CSG | positive regulation of mRNA splicing, via spliceosome | 6/1034 | 22/18723 | 9.71e-04 | 1.25e-02 | 6 |
GO:000838011 | Stomach | CSG | RNA splicing | 40/1034 | 434/18723 | 1.07e-03 | 1.35e-02 | 40 |
GO:004348421 | Stomach | CSG | regulation of RNA splicing | 18/1034 | 148/18723 | 1.36e-03 | 1.58e-02 | 18 |
GO:000037711 | Stomach | CSG | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 31/1034 | 320/18723 | 1.74e-03 | 1.89e-02 | 31 |
GO:000039811 | Stomach | CSG | mRNA splicing, via spliceosome | 31/1034 | 320/18723 | 1.74e-03 | 1.89e-02 | 31 |
GO:000989521 | Stomach | CSG | negative regulation of catabolic process | 31/1034 | 320/18723 | 1.74e-03 | 1.89e-02 | 31 |
GO:000037511 | Stomach | CSG | RNA splicing, via transesterification reactions | 31/1034 | 324/18723 | 2.11e-03 | 2.17e-02 | 31 |
GO:003312021 | Stomach | CSG | positive regulation of RNA splicing | 7/1034 | 37/18723 | 3.68e-03 | 3.27e-02 | 7 |
GO:004802411 | Stomach | CSG | regulation of mRNA splicing, via spliceosome | 13/1034 | 101/18723 | 3.68e-03 | 3.27e-02 | 13 |
GO:190331211 | Stomach | CSG | negative regulation of mRNA metabolic process | 12/1034 | 92/18723 | 4.63e-03 | 3.90e-02 | 12 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CIRBP | SNV | Missense_Mutation | | c.820N>A | p.Val274Met | p.V274M | | protein_coding | tolerated_low_confidence(0.09) | benign(0.017) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
CIRBP | SNV | Missense_Mutation | rs749046630 | c.493N>A | p.Asp165Asn | p.D165N | | protein_coding | deleterious(0) | possibly_damaging(0.632) | TCGA-A8-A0AD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
CIRBP | SNV | Missense_Mutation | rs148277498 | c.791N>A | p.Arg264His | p.R264H | | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-E2-A14Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD |
CIRBP | SNV | Missense_Mutation | | c.758C>G | p.Ser253Cys | p.S253C | | protein_coding | tolerated_low_confidence(0.06) | benign(0.146) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
CIRBP | SNV | Missense_Mutation | | c.80C>T | p.Ser27Leu | p.S27L | | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
CIRBP | SNV | Missense_Mutation | novel | c.643C>G | p.Gln215Glu | p.Q215E | | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CIRBP | SNV | Missense_Mutation | | c.98N>T | p.Ser33Phe | p.S33F | | protein_coding | deleterious(0.04) | probably_damaging(0.986) | TCGA-EA-A3HQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CIRBP | SNV | Missense_Mutation | | c.731N>A | p.Arg244Lys | p.R244K | | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
CIRBP | SNV | Missense_Mutation | rs11555031 | c.49N>G | p.Thr17Ala | p.T17A | | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CIRBP | SNV | Missense_Mutation | | c.5N>T | p.Ala2Val | p.A2V | | protein_coding | deleterious(0) | possibly_damaging(0.526) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |