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Gene: C3 |
Gene summary for C3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | C3 | Gene ID | 718 |
Gene name | complement C3 | |
Gene Alias | AHUS5 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DR57 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
718 | C3 | CA_HPV_1 | Human | Cervix | CC | 2.81e-16 | -6.77e-01 | 0.0264 |
718 | C3 | CA_HPV_2 | Human | Cervix | CC | 5.69e-14 | -6.93e-01 | 0.0391 |
718 | C3 | CA_HPV_3 | Human | Cervix | CC | 1.59e-11 | -6.38e-01 | 0.0414 |
718 | C3 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 1.15e-05 | -3.77e-01 | 0.0208 |
718 | C3 | N_HPV_1 | Human | Cervix | N_HPV | 5.84e-08 | -5.69e-01 | 0.0079 |
718 | C3 | N_HPV_2 | Human | Cervix | N_HPV | 7.40e-09 | -5.13e-01 | -0.0131 |
718 | C3 | CCI_1 | Human | Cervix | CC | 4.72e-05 | -7.56e-01 | 0.528 |
718 | C3 | CCI_2 | Human | Cervix | CC | 2.04e-06 | -7.76e-01 | 0.5249 |
718 | C3 | CCII_1 | Human | Cervix | CC | 1.08e-10 | -7.53e-01 | 0.3249 |
718 | C3 | Tumor | Human | Cervix | CC | 2.51e-17 | -6.99e-01 | 0.1241 |
718 | C3 | sample1 | Human | Cervix | CC | 1.27e-03 | -8.83e-02 | 0.0959 |
718 | C3 | sample3 | Human | Cervix | CC | 1.11e-15 | -6.38e-01 | 0.1387 |
718 | C3 | L1 | Human | Cervix | CC | 5.63e-10 | -7.17e-01 | 0.0802 |
718 | C3 | T1 | Human | Cervix | CC | 7.61e-07 | 3.87e-02 | 0.0918 |
718 | C3 | T3 | Human | Cervix | CC | 1.15e-14 | -6.42e-01 | 0.1389 |
718 | C3 | AEH-subject1 | Human | Endometrium | AEH | 7.07e-65 | 1.25e+00 | -0.3059 |
718 | C3 | AEH-subject2 | Human | Endometrium | AEH | 1.57e-48 | 1.18e+00 | -0.2525 |
718 | C3 | AEH-subject3 | Human | Endometrium | AEH | 1.88e-35 | 8.97e-01 | -0.2576 |
718 | C3 | AEH-subject4 | Human | Endometrium | AEH | 1.17e-22 | 7.89e-01 | -0.2657 |
718 | C3 | EEC-subject2 | Human | Endometrium | EEC | 2.38e-40 | 1.01e+00 | -0.2607 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000989621 | Stomach | CSG | positive regulation of catabolic process | 46/1034 | 492/18723 | 3.45e-04 | 5.74e-03 | 46 |
GO:003461421 | Stomach | CSG | cellular response to reactive oxygen species | 20/1034 | 155/18723 | 3.51e-04 | 5.79e-03 | 20 |
GO:000724921 | Stomach | CSG | I-kappaB kinase/NF-kappaB signaling | 30/1034 | 281/18723 | 4.30e-04 | 6.76e-03 | 30 |
GO:00713842 | Stomach | CSG | cellular response to corticosteroid stimulus | 11/1034 | 61/18723 | 4.54e-04 | 7.10e-03 | 11 |
GO:00427422 | Stomach | CSG | defense response to bacterium | 35/1034 | 350/18723 | 5.14e-04 | 7.88e-03 | 35 |
GO:190390021 | Stomach | CSG | regulation of viral life cycle | 19/1034 | 148/18723 | 5.21e-04 | 7.89e-03 | 19 |
GO:00712482 | Stomach | CSG | cellular response to metal ion | 23/1034 | 197/18723 | 5.68e-04 | 8.32e-03 | 23 |
GO:00096152 | Stomach | CSG | response to virus | 36/1034 | 367/18723 | 6.16e-04 | 8.96e-03 | 36 |
GO:004312321 | Stomach | CSG | positive regulation of I-kappaB kinase/NF-kappaB signaling | 22/1034 | 186/18723 | 6.21e-04 | 9.00e-03 | 22 |
GO:00027642 | Stomach | CSG | immune response-regulating signaling pathway | 43/1034 | 468/18723 | 7.58e-04 | 1.04e-02 | 43 |
GO:003052221 | Stomach | CSG | intracellular receptor signaling pathway | 28/1034 | 265/18723 | 7.73e-04 | 1.06e-02 | 28 |
GO:009730521 | Stomach | CSG | response to alcohol | 27/1034 | 253/18723 | 8.18e-04 | 1.11e-02 | 27 |
GO:200011721 | Stomach | CSG | negative regulation of cysteine-type endopeptidase activity | 13/1034 | 86/18723 | 8.40e-04 | 1.13e-02 | 13 |
GO:007149621 | Stomach | CSG | cellular response to external stimulus | 32/1034 | 320/18723 | 8.75e-04 | 1.17e-02 | 32 |
GO:00713982 | Stomach | CSG | cellular response to fatty acid | 8/1034 | 38/18723 | 9.35e-04 | 1.22e-02 | 8 |
GO:200037721 | Stomach | CSG | regulation of reactive oxygen species metabolic process | 19/1034 | 157/18723 | 1.08e-03 | 1.35e-02 | 19 |
GO:00015162 | Stomach | CSG | prostaglandin biosynthetic process | 7/1034 | 31/18723 | 1.25e-03 | 1.50e-02 | 7 |
GO:00464572 | Stomach | CSG | prostanoid biosynthetic process | 7/1034 | 31/18723 | 1.25e-03 | 1.50e-02 | 7 |
GO:00306382 | Stomach | CSG | polyketide metabolic process | 4/1034 | 10/18723 | 1.48e-03 | 1.68e-02 | 4 |
GO:00306472 | Stomach | CSG | aminoglycoside antibiotic metabolic process | 4/1034 | 10/18723 | 1.48e-03 | 1.68e-02 | 4 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0414520 | Cervix | CC | Phagosome | 47/1267 | 152/8465 | 3.95e-07 | 4.26e-06 | 2.52e-06 | 47 |
hsa0513416 | Cervix | CC | Legionellosis | 20/1267 | 57/8465 | 1.29e-04 | 8.19e-04 | 4.85e-04 | 20 |
hsa05152 | Cervix | CC | Tuberculosis | 42/1267 | 180/8465 | 1.78e-03 | 7.21e-03 | 4.26e-03 | 42 |
hsa051337 | Cervix | CC | Pertussis | 21/1267 | 76/8465 | 3.08e-03 | 1.19e-02 | 7.03e-03 | 21 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa04145110 | Cervix | CC | Phagosome | 47/1267 | 152/8465 | 3.95e-07 | 4.26e-06 | 2.52e-06 | 47 |
hsa0513417 | Cervix | CC | Legionellosis | 20/1267 | 57/8465 | 1.29e-04 | 8.19e-04 | 4.85e-04 | 20 |
hsa051521 | Cervix | CC | Tuberculosis | 42/1267 | 180/8465 | 1.78e-03 | 7.21e-03 | 4.26e-03 | 42 |
hsa0513312 | Cervix | CC | Pertussis | 21/1267 | 76/8465 | 3.08e-03 | 1.19e-02 | 7.03e-03 | 21 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa051504 | Cervix | HSIL_HPV | Staphylococcus aureus infection | 21/459 | 96/8465 | 2.93e-08 | 1.43e-06 | 1.16e-06 | 21 |
hsa0414523 | Cervix | HSIL_HPV | Phagosome | 27/459 | 152/8465 | 3.58e-08 | 1.50e-06 | 1.21e-06 | 27 |
hsa0514022 | Cervix | HSIL_HPV | Leishmaniasis | 18/459 | 77/8465 | 9.82e-08 | 3.14e-06 | 2.54e-06 | 18 |
hsa0513423 | Cervix | HSIL_HPV | Legionellosis | 12/459 | 57/8465 | 4.24e-05 | 6.21e-04 | 5.02e-04 | 12 |
hsa05322 | Cervix | HSIL_HPV | Systemic lupus erythematosus | 19/459 | 137/8465 | 1.40e-04 | 1.74e-03 | 1.40e-03 | 19 |
hsa0513125 | Cervix | HSIL_HPV | Shigellosis | 27/459 | 247/8465 | 3.78e-04 | 3.49e-03 | 2.82e-03 | 27 |
hsa051522 | Cervix | HSIL_HPV | Tuberculosis | 19/459 | 180/8465 | 3.99e-03 | 2.39e-02 | 1.93e-02 | 19 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
C3 | C3AR1 | C3_C3AR1 | COMPLEMENT | Breast | DCIS |
C3 | ITGAM_ITGB2 | C3_ITGAM_ITGB2 | COMPLEMENT | Breast | DCIS |
C3 | ITGAX_ITGB2 | C3_ITGAX_ITGB2 | COMPLEMENT | Breast | DCIS |
PTN | SDC3 | PTN_SDC3 | PTN | Breast | DCIS |
ANGPTL4 | SDC3 | ANGPTL4_SDC3 | ANGPTL | Breast | DCIS |
C3 | C3AR1 | C3_C3AR1 | COMPLEMENT | Breast | Healthy |
C3 | ITGAM_ITGB2 | C3_ITGAM_ITGB2 | COMPLEMENT | Breast | Healthy |
C3 | ITGAX_ITGB2 | C3_ITGAX_ITGB2 | COMPLEMENT | Breast | Healthy |
ANGPTL4 | SDC3 | ANGPTL4_SDC3 | ANGPTL | Breast | IDC |
C3 | C3AR1 | C3_C3AR1 | COMPLEMENT | Breast | IDC |
C3 | ITGAM_ITGB2 | C3_ITGAM_ITGB2 | COMPLEMENT | Breast | IDC |
C3 | ITGAX_ITGB2 | C3_ITGAX_ITGB2 | COMPLEMENT | Breast | IDC |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Breast | IDC |
C3 | C3AR1 | C3_C3AR1 | COMPLEMENT | Cervix | ADJ |
C3 | ITGAM_ITGB2 | C3_ITGAM_ITGB2 | COMPLEMENT | Cervix | ADJ |
C3 | ITGAX_ITGB2 | C3_ITGAX_ITGB2 | COMPLEMENT | Cervix | ADJ |
PTN | SDC3 | PTN_SDC3 | PTN | Cervix | CC |
DSG2 | DSC3 | DSG2_DSC3 | DESMOSOME | Cervix | CC |
ANGPTL4 | SDC3 | ANGPTL4_SDC3 | ANGPTL | Cervix | CC |
C3 | C3AR1 | C3_C3AR1 | COMPLEMENT | Cervix | CC |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C3 | SNV | Missense_Mutation | novel | c.2800N>C | p.Glu934Gln | p.E934Q | P01024 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
C3 | SNV | Missense_Mutation | c.1052C>T | p.Ser351Phe | p.S351F | P01024 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A2-A0SY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD | |
C3 | SNV | Missense_Mutation | rs199911426 | c.4594N>T | p.Arg1532Trp | p.R1532W | P01024 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |
C3 | SNV | Missense_Mutation | c.4276N>A | p.Asp1426Asn | p.D1426N | P01024 | protein_coding | deleterious(0.01) | probably_damaging(0.929) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C3 | SNV | Missense_Mutation | c.3803N>G | p.Ser1268Cys | p.S1268C | P01024 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C3 | SNV | Missense_Mutation | c.1376N>T | p.Ser459Leu | p.S459L | P01024 | protein_coding | tolerated(0.09) | possibly_damaging(0.599) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C3 | SNV | Missense_Mutation | novel | c.4408N>A | p.Glu1470Lys | p.E1470K | P01024 | protein_coding | deleterious(0) | benign(0.188) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C3 | SNV | Missense_Mutation | novel | c.3118G>C | p.Glu1040Gln | p.E1040Q | P01024 | protein_coding | tolerated(0.11) | benign(0.063) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
C3 | SNV | Missense_Mutation | novel | c.2782N>G | p.Ser928Ala | p.S928A | P01024 | protein_coding | tolerated(0.22) | benign(0.007) | TCGA-BH-A0DG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
C3 | SNV | Missense_Mutation | c.1452N>T | p.Glu484Asp | p.E484D | P01024 | protein_coding | tolerated(0.52) | benign(0.003) | TCGA-D8-A1XG-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
718 | C3 | PROTEASE INHIBITOR, DRUGGABLE GENOME, CELL SURFACE | Imprime PGG immunotherapeutic | |||
718 | C3 | PROTEASE INHIBITOR, DRUGGABLE GENOME, CELL SURFACE | POT-4 | 19025129 | ||
718 | C3 | PROTEASE INHIBITOR, DRUGGABLE GENOME, CELL SURFACE | COMPSTATIN | COMPSTATIN | 25494040 | |
718 | C3 | PROTEASE INHIBITOR, DRUGGABLE GENOME, CELL SURFACE | POT-4 | |||
718 | C3 | PROTEASE INHIBITOR, DRUGGABLE GENOME, CELL SURFACE | APL-2 | PEGCETACOPLAN | ||
718 | C3 | PROTEASE INHIBITOR, DRUGGABLE GENOME, CELL SURFACE | clozapine | CLOZAPINE | 26503818 |
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