Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004620921 | Stomach | CSG | nitric oxide metabolic process | 15/1034 | 81/18723 | 3.22e-05 | 8.93e-04 | 15 |
GO:200105721 | Stomach | CSG | reactive nitrogen species metabolic process | 15/1034 | 82/18723 | 3.75e-05 | 1.00e-03 | 15 |
GO:008016421 | Stomach | CSG | regulation of nitric oxide metabolic process | 13/1034 | 64/18723 | 3.90e-05 | 1.04e-03 | 13 |
GO:004346721 | Stomach | CSG | regulation of generation of precursor metabolites and energy | 19/1034 | 130/18723 | 9.48e-05 | 2.15e-03 | 19 |
GO:00026832 | Stomach | CSG | negative regulation of immune system process | 43/1034 | 434/18723 | 1.54e-04 | 3.14e-03 | 43 |
GO:00324962 | Stomach | CSG | response to lipopolysaccharide | 36/1034 | 343/18723 | 1.69e-04 | 3.33e-03 | 36 |
GO:190589721 | Stomach | CSG | regulation of response to endoplasmic reticulum stress | 13/1034 | 82/18723 | 5.28e-04 | 7.97e-03 | 13 |
GO:190223621 | Stomach | CSG | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 6/1034 | 20/18723 | 5.55e-04 | 8.22e-03 | 6 |
GO:00712222 | Stomach | CSG | cellular response to lipopolysaccharide | 24/1034 | 209/18723 | 5.55e-04 | 8.22e-03 | 24 |
GO:003497621 | Stomach | CSG | response to endoplasmic reticulum stress | 27/1034 | 256/18723 | 9.77e-04 | 1.25e-02 | 27 |
GO:00326402 | Stomach | CSG | tumor necrosis factor production | 21/1034 | 181/18723 | 1.05e-03 | 1.33e-02 | 21 |
GO:00326802 | Stomach | CSG | regulation of tumor necrosis factor production | 21/1034 | 181/18723 | 1.05e-03 | 1.33e-02 | 21 |
GO:001049811 | Stomach | CSG | proteasomal protein catabolic process | 44/1034 | 490/18723 | 1.06e-03 | 1.34e-02 | 44 |
GO:00712192 | Stomach | CSG | cellular response to molecule of bacterial origin | 24/1034 | 221/18723 | 1.22e-03 | 1.48e-02 | 24 |
GO:00717062 | Stomach | CSG | tumor necrosis factor superfamily cytokine production | 21/1034 | 186/18723 | 1.48e-03 | 1.68e-02 | 21 |
GO:19035552 | Stomach | CSG | regulation of tumor necrosis factor superfamily cytokine production | 21/1034 | 186/18723 | 1.48e-03 | 1.68e-02 | 21 |
GO:007005921 | Stomach | CSG | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 10/1034 | 63/18723 | 2.24e-03 | 2.25e-02 | 10 |
GO:00309682 | Stomach | CSG | endoplasmic reticulum unfolded protein response | 11/1034 | 74/18723 | 2.36e-03 | 2.36e-02 | 11 |
GO:00712162 | Stomach | CSG | cellular response to biotic stimulus | 25/1034 | 246/18723 | 2.46e-03 | 2.44e-02 | 25 |
GO:004343421 | Stomach | CSG | response to peptide hormone | 37/1034 | 414/18723 | 2.75e-03 | 2.62e-02 | 37 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414118 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414119 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414124 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414134 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414143 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414153 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041418 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa041419 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa0414126 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa04141111 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa0414127 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414136 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |