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Gene: PTGES |
Gene summary for PTGES |
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Gene information | Species | Human | Gene symbol | PTGES | Gene ID | 9536 |
Gene name | prostaglandin E synthase | |
Gene Alias | MGST-IV | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0001516 | UniProtAcc | O14684 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9536 | PTGES | LZE8T | Human | Esophagus | ESCC | 1.39e-02 | 2.31e-01 | 0.067 |
9536 | PTGES | LZE20T | Human | Esophagus | ESCC | 4.35e-12 | 9.43e-01 | 0.0662 |
9536 | PTGES | LZE22T | Human | Esophagus | ESCC | 7.45e-04 | 6.20e-01 | 0.068 |
9536 | PTGES | LZE24D1 | Human | Esophagus | HGIN | 1.13e-02 | 1.06e+00 | 0.054 |
9536 | PTGES | LZE24T | Human | Esophagus | ESCC | 1.44e-04 | 5.23e-01 | 0.0596 |
9536 | PTGES | LZE21T | Human | Esophagus | ESCC | 5.87e-03 | 2.90e-01 | 0.0655 |
9536 | PTGES | LZE6T | Human | Esophagus | ESCC | 1.46e-11 | 1.75e+00 | 0.0845 |
9536 | PTGES | P1T-E | Human | Esophagus | ESCC | 1.79e-06 | 1.24e+00 | 0.0875 |
9536 | PTGES | P2T-E | Human | Esophagus | ESCC | 5.31e-23 | 6.63e-01 | 0.1177 |
9536 | PTGES | P4T-E | Human | Esophagus | ESCC | 5.86e-12 | 5.34e-01 | 0.1323 |
9536 | PTGES | P8T-E | Human | Esophagus | ESCC | 1.85e-32 | 1.21e+00 | 0.0889 |
9536 | PTGES | P11T-E | Human | Esophagus | ESCC | 1.08e-12 | 1.20e+00 | 0.1426 |
9536 | PTGES | P15T-E | Human | Esophagus | ESCC | 1.69e-05 | 4.01e-01 | 0.1149 |
9536 | PTGES | P17T-E | Human | Esophagus | ESCC | 6.20e-08 | 6.62e-01 | 0.1278 |
9536 | PTGES | P21T-E | Human | Esophagus | ESCC | 1.45e-22 | 6.97e-01 | 0.1617 |
9536 | PTGES | P22T-E | Human | Esophagus | ESCC | 7.63e-11 | 2.53e-01 | 0.1236 |
9536 | PTGES | P23T-E | Human | Esophagus | ESCC | 1.27e-18 | 1.47e+00 | 0.108 |
9536 | PTGES | P24T-E | Human | Esophagus | ESCC | 1.52e-18 | 8.49e-01 | 0.1287 |
9536 | PTGES | P26T-E | Human | Esophagus | ESCC | 9.26e-13 | 5.03e-01 | 0.1276 |
9536 | PTGES | P27T-E | Human | Esophagus | ESCC | 8.02e-03 | 1.12e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005197231 | Stomach | CAG | regulation of telomerase activity | 7/552 | 47/18723 | 4.21e-04 | 7.49e-03 | 7 |
GO:001083321 | Stomach | CAG | telomere maintenance via telomere lengthening | 9/552 | 81/18723 | 6.24e-04 | 1.02e-02 | 9 |
GO:000700421 | Stomach | CAG | telomere maintenance via telomerase | 8/552 | 69/18723 | 9.34e-04 | 1.38e-02 | 8 |
GO:00062784 | Stomach | CAG | RNA-dependent DNA biosynthetic process | 8/552 | 75/18723 | 1.62e-03 | 1.93e-02 | 8 |
GO:00335593 | Stomach | CAG | unsaturated fatty acid metabolic process | 10/552 | 116/18723 | 2.28e-03 | 2.50e-02 | 10 |
GO:007189721 | Stomach | CAG | DNA biosynthetic process | 13/552 | 180/18723 | 2.69e-03 | 2.77e-02 | 13 |
GO:005197331 | Stomach | CAG | positive regulation of telomerase activity | 5/552 | 34/18723 | 3.00e-03 | 3.00e-02 | 5 |
GO:00066923 | Stomach | CAG | prostanoid metabolic process | 6/552 | 49/18723 | 3.05e-03 | 3.01e-02 | 6 |
GO:00066933 | Stomach | CAG | prostaglandin metabolic process | 6/552 | 49/18723 | 3.05e-03 | 3.01e-02 | 6 |
GO:200057321 | Stomach | CAG | positive regulation of DNA biosynthetic process | 7/552 | 66/18723 | 3.23e-03 | 3.14e-02 | 7 |
GO:00066903 | Stomach | CAG | icosanoid metabolic process | 10/552 | 123/18723 | 3.50e-03 | 3.32e-02 | 10 |
GO:00007236 | Stomach | CAG | telomere maintenance | 10/552 | 131/18723 | 5.46e-03 | 4.55e-02 | 10 |
GO:00464562 | Stomach | CAG | icosanoid biosynthetic process | 6/552 | 56/18723 | 5.95e-03 | 4.77e-02 | 6 |
GO:000645741 | Stomach | WIM | protein folding | 28/426 | 212/18723 | 6.19e-14 | 8.17e-11 | 28 |
GO:00510854 | Stomach | WIM | chaperone cofactor-dependent protein refolding | 11/426 | 34/18723 | 1.33e-10 | 5.89e-08 | 11 |
GO:00064584 | Stomach | WIM | 'de novo' protein folding | 12/426 | 43/18723 | 1.34e-10 | 5.89e-08 | 12 |
GO:00610774 | Stomach | WIM | chaperone-mediated protein folding | 14/426 | 67/18723 | 2.63e-10 | 1.04e-07 | 14 |
GO:00510844 | Stomach | WIM | 'de novo' posttranslational protein folding | 11/426 | 39/18723 | 7.03e-10 | 1.74e-07 | 11 |
GO:000609141 | Stomach | WIM | generation of precursor metabolites and energy | 34/426 | 490/18723 | 8.83e-09 | 1.40e-06 | 34 |
GO:00335594 | Stomach | WIM | unsaturated fatty acid metabolic process | 14/426 | 116/18723 | 3.95e-07 | 3.13e-05 | 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGES | SNV | Missense_Mutation | c.296N>T | p.Ala99Val | p.A99V | O14684 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTGES | SNV | Missense_Mutation | c.421N>C | p.Ala141Pro | p.A141P | O14684 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-EI-7002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | irinotecan+5-fluorouracilim | SD | |
PTGES | SNV | Missense_Mutation | rs551621700 | c.365G>A | p.Arg122Gln | p.R122Q | O14684 | protein_coding | tolerated(0.2) | benign(0.024) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGES | SNV | Missense_Mutation | c.374T>C | p.Ile125Thr | p.I125T | O14684 | protein_coding | tolerated(1) | benign(0) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTGES | SNV | Missense_Mutation | c.244N>A | p.Phe82Ile | p.F82I | O14684 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FV-A3R3-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTGES | SNV | Missense_Mutation | c.190N>C | p.Asp64His | p.D64H | O14684 | protein_coding | tolerated(0.05) | probably_damaging(0.971) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PTGES | SNV | Missense_Mutation | novel | c.167C>A | p.Pro56His | p.P56H | O14684 | protein_coding | tolerated(0.14) | benign(0.343) | TCGA-37-3789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PTGES | deletion | Frame_Shift_Del | c.189delC | p.Asp64ThrfsTer65 | p.D64Tfs*65 | O14684 | protein_coding | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9536 | PTGES | DRUGGABLE GENOME, ENZYME | Benzamide derivative 14 | |||
9536 | PTGES | DRUGGABLE GENOME, ENZYME | Benzimidazole derivative 13 | |||
9536 | PTGES | DRUGGABLE GENOME, ENZYME | VEGF | 16155957 | ||
9536 | PTGES | DRUGGABLE GENOME, ENZYME | Imidazopyridine derivative 5 | |||
9536 | PTGES | DRUGGABLE GENOME, ENZYME | Imidazole benzamide derivative 1 | |||
9536 | PTGES | DRUGGABLE GENOME, ENZYME | inhibitor | 252827532 | ||
9536 | PTGES | DRUGGABLE GENOME, ENZYME | Alpha-substituted pirinixic acid and pirinixic acid ester derivative 1 | |||
9536 | PTGES | DRUGGABLE GENOME, ENZYME | Imidazopyridine derivative 6 | |||
9536 | PTGES | DRUGGABLE GENOME, ENZYME | PMID28627961-Compound-30 | |||
9536 | PTGES | DRUGGABLE GENOME, ENZYME | Methyl-piperidine compound 1 |
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