Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/FIS1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/FIS1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/FIS1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/FIS1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/FIS1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/FIS1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/FIS1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/FIS1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/FIS1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/FIS1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/FIS1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200011632 | Oral cavity | NEOLP | regulation of cysteine-type endopeptidase activity | 55/2005 | 235/18723 | 1.59e-08 | 7.25e-07 | 55 |
GO:190382932 | Oral cavity | NEOLP | positive regulation of cellular protein localization | 61/2005 | 276/18723 | 2.63e-08 | 1.14e-06 | 61 |
GO:003315731 | Oral cavity | NEOLP | regulation of intracellular protein transport | 53/2005 | 229/18723 | 4.28e-08 | 1.77e-06 | 53 |
GO:004328132 | Oral cavity | NEOLP | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 49/2005 | 209/18723 | 8.94e-08 | 3.36e-06 | 49 |
GO:200123532 | Oral cavity | NEOLP | positive regulation of apoptotic signaling pathway | 34/2005 | 126/18723 | 2.55e-07 | 8.23e-06 | 34 |
GO:007048232 | Oral cavity | NEOLP | response to oxygen levels | 69/2005 | 347/18723 | 2.66e-07 | 8.54e-06 | 69 |
GO:000166632 | Oral cavity | NEOLP | response to hypoxia | 63/2005 | 307/18723 | 2.75e-07 | 8.78e-06 | 63 |
GO:000963633 | Oral cavity | NEOLP | response to toxic substance | 56/2005 | 262/18723 | 3.13e-07 | 9.85e-06 | 56 |
GO:003629332 | Oral cavity | NEOLP | response to decreased oxygen levels | 65/2005 | 322/18723 | 3.34e-07 | 1.04e-05 | 65 |
GO:009723732 | Oral cavity | NEOLP | cellular response to toxic substance | 33/2005 | 124/18723 | 5.39e-07 | 1.61e-05 | 33 |
GO:003238831 | Oral cavity | NEOLP | positive regulation of intracellular transport | 45/2005 | 202/18723 | 1.35e-06 | 3.46e-05 | 45 |
GO:190495133 | Oral cavity | NEOLP | positive regulation of establishment of protein localization | 61/2005 | 319/18723 | 4.85e-06 | 1.03e-04 | 61 |
GO:001095232 | Oral cavity | NEOLP | positive regulation of peptidase activity | 42/2005 | 197/18723 | 9.62e-06 | 1.82e-04 | 42 |
GO:009031631 | Oral cavity | NEOLP | positive regulation of intracellular protein transport | 36/2005 | 160/18723 | 1.18e-05 | 2.15e-04 | 36 |
GO:005122233 | Oral cavity | NEOLP | positive regulation of protein transport | 57/2005 | 303/18723 | 1.62e-05 | 2.79e-04 | 57 |
GO:003246931 | Oral cavity | NEOLP | endoplasmic reticulum calcium ion homeostasis | 11/2005 | 25/18723 | 2.21e-05 | 3.60e-04 | 11 |
GO:200124432 | Oral cavity | NEOLP | positive regulation of intrinsic apoptotic signaling pathway | 17/2005 | 58/18723 | 8.04e-05 | 1.01e-03 | 17 |
GO:003166732 | Oral cavity | NEOLP | response to nutrient levels | 77/2005 | 474/18723 | 1.27e-04 | 1.49e-03 | 77 |
GO:190300831 | Oral cavity | NEOLP | organelle disassembly | 25/2005 | 114/18723 | 3.66e-04 | 3.49e-03 | 25 |
GO:007099732 | Oral cavity | NEOLP | neuron death | 60/2005 | 361/18723 | 3.70e-04 | 3.50e-03 | 60 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FIS1 | SNV | Missense_Mutation | novel | c.357N>C | p.Lys119Asn | p.K119N | Q9Y3D6 | protein_coding | tolerated(0.14) | benign(0.102) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FIS1 | SNV | Missense_Mutation | | c.349G>T | p.Ala117Ser | p.A117S | Q9Y3D6 | protein_coding | tolerated(0.08) | benign(0.429) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
FIS1 | SNV | Missense_Mutation | novel | c.350C>T | p.Ala117Val | p.A117V | Q9Y3D6 | protein_coding | deleterious(0.05) | benign(0.41) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FIS1 | SNV | Missense_Mutation | | c.439N>A | p.Val147Met | p.V147M | Q9Y3D6 | protein_coding | tolerated(0.58) | possibly_damaging(0.49) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FIS1 | SNV | Missense_Mutation | rs776529563 | c.430G>A | p.Gly144Arg | p.G144R | Q9Y3D6 | protein_coding | deleterious(0.03) | probably_damaging(0.964) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FIS1 | SNV | Missense_Mutation | novel | c.130N>T | p.Arg44Trp | p.R44W | Q9Y3D6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
FIS1 | SNV | Missense_Mutation | | c.233N>T | p.Ala78Val | p.A78V | Q9Y3D6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FIS1 | SNV | Missense_Mutation | novel | c.421N>A | p.Gly141Arg | p.G141R | Q9Y3D6 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FIS1 | SNV | Missense_Mutation | novel | c.62N>G | p.Phe21Cys | p.F21C | Q9Y3D6 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FIS1 | SNV | Missense_Mutation | novel | c.421G>A | p.Gly141Arg | p.G141R | Q9Y3D6 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |