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Gene: ATP5F1B |
Gene summary for ATP5F1B |
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Gene information | Species | Human | Gene symbol | ATP5F1B | Gene ID | 506 |
Gene name | ATP synthase F1 subunit beta | |
Gene Alias | ATP5B | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | P06576 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
506 | ATP5F1B | GSM4909285 | Human | Breast | IDC | 4.38e-61 | 1.01e+00 | 0.21 |
506 | ATP5F1B | GSM4909286 | Human | Breast | IDC | 1.26e-09 | 1.14e-01 | 0.1081 |
506 | ATP5F1B | GSM4909289 | Human | Breast | IDC | 3.99e-03 | 5.60e-01 | 0.1064 |
506 | ATP5F1B | GSM4909291 | Human | Breast | IDC | 4.61e-07 | 4.69e-01 | 0.1753 |
506 | ATP5F1B | GSM4909293 | Human | Breast | IDC | 1.73e-15 | 3.13e-01 | 0.1581 |
506 | ATP5F1B | GSM4909294 | Human | Breast | IDC | 3.73e-04 | 3.03e-01 | 0.2022 |
506 | ATP5F1B | GSM4909297 | Human | Breast | IDC | 1.32e-03 | 2.85e-02 | 0.1517 |
506 | ATP5F1B | GSM4909298 | Human | Breast | IDC | 1.60e-04 | 7.18e-02 | 0.1551 |
506 | ATP5F1B | GSM4909304 | Human | Breast | IDC | 1.99e-11 | 4.36e-01 | 0.1636 |
506 | ATP5F1B | GSM4909305 | Human | Breast | IDC | 1.29e-10 | 4.21e-01 | 0.0436 |
506 | ATP5F1B | GSM4909306 | Human | Breast | IDC | 1.08e-03 | 2.97e-01 | 0.1564 |
506 | ATP5F1B | GSM4909308 | Human | Breast | IDC | 1.51e-07 | 3.10e-01 | 0.158 |
506 | ATP5F1B | GSM4909311 | Human | Breast | IDC | 6.99e-17 | -1.12e-01 | 0.1534 |
506 | ATP5F1B | GSM4909312 | Human | Breast | IDC | 5.24e-04 | 2.10e-01 | 0.1552 |
506 | ATP5F1B | GSM4909317 | Human | Breast | IDC | 1.98e-11 | 4.37e-01 | 0.1355 |
506 | ATP5F1B | GSM4909318 | Human | Breast | IDC | 7.79e-03 | 5.18e-01 | 0.2031 |
506 | ATP5F1B | GSM4909319 | Human | Breast | IDC | 3.68e-25 | -9.04e-02 | 0.1563 |
506 | ATP5F1B | GSM4909321 | Human | Breast | IDC | 1.98e-27 | 6.42e-01 | 0.1559 |
506 | ATP5F1B | brca1 | Human | Breast | Precancer | 1.63e-27 | -4.97e-01 | -0.0338 |
506 | ATP5F1B | brca2 | Human | Breast | Precancer | 7.84e-25 | -4.97e-01 | -0.024 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000914111 | Stomach | CAG with IM | nucleoside triphosphate metabolic process | 26/1050 | 112/18723 | 4.23e-10 | 6.83e-08 | 26 |
GO:000915011 | Stomach | CAG with IM | purine ribonucleotide metabolic process | 48/1050 | 368/18723 | 4.36e-08 | 3.32e-06 | 48 |
GO:000616311 | Stomach | CAG with IM | purine nucleotide metabolic process | 50/1050 | 396/18723 | 6.52e-08 | 4.63e-06 | 50 |
GO:000925911 | Stomach | CAG with IM | ribonucleotide metabolic process | 48/1050 | 385/18723 | 1.76e-07 | 1.16e-05 | 48 |
GO:000915211 | Stomach | CAG with IM | purine ribonucleotide biosynthetic process | 28/1050 | 169/18723 | 2.35e-07 | 1.51e-05 | 28 |
GO:007252111 | Stomach | CAG with IM | purine-containing compound metabolic process | 50/1050 | 416/18723 | 3.04e-07 | 1.82e-05 | 50 |
GO:001969311 | Stomach | CAG with IM | ribose phosphate metabolic process | 48/1050 | 396/18723 | 4.08e-07 | 2.34e-05 | 48 |
GO:199054211 | Stomach | CAG with IM | mitochondrial transmembrane transport | 20/1050 | 102/18723 | 8.13e-07 | 4.05e-05 | 20 |
GO:000926011 | Stomach | CAG with IM | ribonucleotide biosynthetic process | 28/1050 | 182/18723 | 1.11e-06 | 5.44e-05 | 28 |
GO:000911711 | Stomach | CAG with IM | nucleotide metabolic process | 54/1050 | 489/18723 | 1.52e-06 | 7.14e-05 | 54 |
GO:000675311 | Stomach | CAG with IM | nucleoside phosphate metabolic process | 54/1050 | 497/18723 | 2.49e-06 | 1.07e-04 | 54 |
GO:004639011 | Stomach | CAG with IM | ribose phosphate biosynthetic process | 28/1050 | 190/18723 | 2.66e-06 | 1.12e-04 | 28 |
GO:000616411 | Stomach | CAG with IM | purine nucleotide biosynthetic process | 28/1050 | 191/18723 | 2.95e-06 | 1.21e-04 | 28 |
GO:007252211 | Stomach | CAG with IM | purine-containing compound biosynthetic process | 28/1050 | 200/18723 | 7.28e-06 | 2.59e-04 | 28 |
GO:000916511 | Stomach | CAG with IM | nucleotide biosynthetic process | 31/1050 | 254/18723 | 3.92e-05 | 1.05e-03 | 31 |
GO:190129311 | Stomach | CAG with IM | nucleoside phosphate biosynthetic process | 31/1050 | 256/18723 | 4.56e-05 | 1.18e-03 | 31 |
GO:001063411 | Stomach | CAG with IM | positive regulation of epithelial cell migration | 19/1050 | 176/18723 | 4.73e-03 | 3.86e-02 | 19 |
GO:004603421 | Stomach | CSG | ATP metabolic process | 70/1034 | 277/18723 | 9.81e-28 | 2.60e-24 | 70 |
GO:000611921 | Stomach | CSG | oxidative phosphorylation | 46/1034 | 141/18723 | 1.12e-23 | 1.97e-20 | 46 |
GO:000906021 | Stomach | CSG | aerobic respiration | 49/1034 | 189/18723 | 2.82e-20 | 3.12e-17 | 49 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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