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Gene: AK4 |
Gene summary for AK4 |
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Gene information | Species | Human | Gene symbol | AK4 | Gene ID | 205 |
Gene name | adenylate kinase 4 | |
Gene Alias | AK 4 | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0001666 | UniProtAcc | P27144 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
205 | AK4 | LZE4T | Human | Esophagus | ESCC | 4.01e-16 | 5.33e-01 | 0.0811 |
205 | AK4 | LZE7T | Human | Esophagus | ESCC | 2.14e-04 | 2.60e-01 | 0.0667 |
205 | AK4 | LZE8T | Human | Esophagus | ESCC | 4.28e-04 | 2.83e-01 | 0.067 |
205 | AK4 | LZE6T | Human | Esophagus | ESCC | 9.71e-04 | 4.03e-01 | 0.0845 |
205 | AK4 | P2T-E | Human | Esophagus | ESCC | 4.34e-18 | 3.41e-01 | 0.1177 |
205 | AK4 | P4T-E | Human | Esophagus | ESCC | 7.28e-15 | 5.60e-01 | 0.1323 |
205 | AK4 | P5T-E | Human | Esophagus | ESCC | 3.22e-30 | 8.02e-01 | 0.1327 |
205 | AK4 | P8T-E | Human | Esophagus | ESCC | 1.01e-03 | 5.43e-02 | 0.0889 |
205 | AK4 | P9T-E | Human | Esophagus | ESCC | 2.15e-14 | 5.86e-01 | 0.1131 |
205 | AK4 | P10T-E | Human | Esophagus | ESCC | 5.77e-20 | 5.09e-01 | 0.116 |
205 | AK4 | P11T-E | Human | Esophagus | ESCC | 4.79e-03 | 2.61e-01 | 0.1426 |
205 | AK4 | P12T-E | Human | Esophagus | ESCC | 7.34e-16 | 4.83e-01 | 0.1122 |
205 | AK4 | P15T-E | Human | Esophagus | ESCC | 5.23e-38 | 1.03e+00 | 0.1149 |
205 | AK4 | P16T-E | Human | Esophagus | ESCC | 4.98e-13 | 3.26e-01 | 0.1153 |
205 | AK4 | P17T-E | Human | Esophagus | ESCC | 4.10e-08 | 7.38e-01 | 0.1278 |
205 | AK4 | P19T-E | Human | Esophagus | ESCC | 1.65e-03 | 9.26e-01 | 0.1662 |
205 | AK4 | P20T-E | Human | Esophagus | ESCC | 3.71e-33 | 7.94e-01 | 0.1124 |
205 | AK4 | P21T-E | Human | Esophagus | ESCC | 2.13e-53 | 1.32e+00 | 0.1617 |
205 | AK4 | P22T-E | Human | Esophagus | ESCC | 1.09e-03 | 1.07e-01 | 0.1236 |
205 | AK4 | P23T-E | Human | Esophagus | ESCC | 1.88e-03 | 1.33e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007249111 | Thyroid | ATC | I-kappaB kinase/NF-kappaB signaling | 135/6293 | 281/18723 | 3.31e-07 | 4.91e-06 | 135 |
GO:003629425 | Thyroid | ATC | cellular response to decreased oxygen levels | 85/6293 | 161/18723 | 3.86e-07 | 5.65e-06 | 85 |
GO:0006753111 | Thyroid | ATC | nucleoside phosphate metabolic process | 219/6293 | 497/18723 | 5.92e-07 | 8.29e-06 | 219 |
GO:199013824 | Thyroid | ATC | neuron projection extension | 89/6293 | 172/18723 | 6.63e-07 | 9.13e-06 | 89 |
GO:000914128 | Thyroid | ATC | nucleoside triphosphate metabolic process | 63/6293 | 112/18723 | 6.90e-07 | 9.35e-06 | 63 |
GO:003109826 | Thyroid | ATC | stress-activated protein kinase signaling cascade | 120/6293 | 247/18723 | 7.06e-07 | 9.46e-06 | 120 |
GO:0009117112 | Thyroid | ATC | nucleotide metabolic process | 215/6293 | 489/18723 | 9.09e-07 | 1.20e-05 | 215 |
GO:000920527 | Thyroid | ATC | purine ribonucleoside triphosphate metabolic process | 49/6293 | 82/18723 | 1.07e-06 | 1.39e-05 | 49 |
GO:004858823 | Thyroid | ATC | developmental cell growth | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
GO:006056019 | Thyroid | ATC | developmental growth involved in morphogenesis | 114/6293 | 234/18723 | 1.11e-06 | 1.44e-05 | 114 |
GO:005140326 | Thyroid | ATC | stress-activated MAPK cascade | 115/6293 | 239/18723 | 2.17e-06 | 2.58e-05 | 115 |
GO:000616328 | Thyroid | ATC | purine nucleotide metabolic process | 177/6293 | 396/18723 | 2.39e-06 | 2.82e-05 | 177 |
GO:007145624 | Thyroid | ATC | cellular response to hypoxia | 78/6293 | 151/18723 | 3.44e-06 | 3.86e-05 | 78 |
GO:000919926 | Thyroid | ATC | ribonucleoside triphosphate metabolic process | 51/6293 | 89/18723 | 3.72e-06 | 4.12e-05 | 51 |
GO:005185121 | Thyroid | ATC | modulation by host of symbiont process | 37/6293 | 60/18723 | 7.87e-06 | 8.04e-05 | 37 |
GO:004346726 | Thyroid | ATC | regulation of generation of precursor metabolites and energy | 68/6293 | 130/18723 | 8.19e-06 | 8.27e-05 | 68 |
GO:000914527 | Thyroid | ATC | purine nucleoside triphosphate biosynthetic process | 41/6293 | 69/18723 | 9.68e-06 | 9.67e-05 | 41 |
GO:000007513 | Thyroid | ATC | cell cycle checkpoint | 84/6293 | 169/18723 | 1.05e-05 | 1.04e-04 | 84 |
GO:000915225 | Thyroid | ATC | purine ribonucleotide biosynthetic process | 84/6293 | 169/18723 | 1.05e-05 | 1.04e-04 | 84 |
GO:001094813 | Thyroid | ATC | negative regulation of cell cycle process | 134/6293 | 294/18723 | 1.19e-05 | 1.15e-04 | 134 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AK4 | SNV | Missense_Mutation | c.262G>A | p.Asp88Asn | p.D88N | P27144 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
AK4 | SNV | Missense_Mutation | rs765366640 | c.451G>A | p.Val151Ile | p.V151I | P27144 | protein_coding | tolerated(0.66) | benign(0) | TCGA-A6-6650-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AK4 | SNV | Missense_Mutation | rs776921061 | c.563G>A | p.Arg188Gln | p.R188Q | P27144 | protein_coding | tolerated(0.16) | benign(0.001) | TCGA-AA-3495-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
AK4 | SNV | Missense_Mutation | c.529N>A | p.Val177Met | p.V177M | P27144 | protein_coding | tolerated(0.1) | possibly_damaging(0.557) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
AK4 | SNV | Missense_Mutation | c.510N>T | p.Arg170Ser | p.R170S | P27144 | protein_coding | deleterious(0) | possibly_damaging(0.827) | TCGA-DC-6154-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
AK4 | SNV | Missense_Mutation | rs138516264 | c.560G>A | p.Ser187Asn | p.S187N | P27144 | protein_coding | tolerated(0.2) | benign(0) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AK4 | insertion | Frame_Shift_Ins | novel | c.664_665insAT | p.Ala222AspfsTer30 | p.A222Dfs*30 | P27144 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
AK4 | insertion | Nonsense_Mutation | novel | c.665_666insCTAG | p.Tyr223Ter | p.Y223* | P27144 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
AK4 | SNV | Missense_Mutation | novel | c.332N>T | p.Ser111Ile | p.S111I | P27144 | protein_coding | deleterious(0.03) | benign(0.316) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
AK4 | SNV | Missense_Mutation | novel | c.289G>T | p.Ala97Ser | p.A97S | P27144 | protein_coding | deleterious(0.02) | possibly_damaging(0.693) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
205 | AK4 | ENZYME, KINASE | tenofovir | TENOFOVIR | ||
205 | AK4 | ENZYME, KINASE | adefovir dipivoxil |
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