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Gene: TF |
Gene summary for TF |
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Gene information | Species | Human | Gene symbol | TF | Gene ID | 7018 |
Gene name | transferrin | |
Gene Alias | HEL-S-71p | |
Cytomap | 3q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | A0PJA6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7018 | TF | P8T-E | Human | Esophagus | ESCC | 1.25e-10 | 4.06e-01 | 0.0889 |
7018 | TF | P10T-E | Human | Esophagus | ESCC | 1.42e-06 | -5.41e-02 | 0.116 |
7018 | TF | P16T-E | Human | Esophagus | ESCC | 1.60e-16 | 2.50e-01 | 0.1153 |
7018 | TF | P22T-E | Human | Esophagus | ESCC | 2.40e-03 | -8.78e-02 | 0.1236 |
7018 | TF | P57T-E | Human | Esophagus | ESCC | 9.24e-21 | 1.12e+00 | 0.0926 |
7018 | TF | P74T-E | Human | Esophagus | ESCC | 2.85e-03 | 1.43e-01 | 0.1479 |
7018 | TF | P76T-E | Human | Esophagus | ESCC | 5.67e-12 | 8.38e-01 | 0.1207 |
7018 | TF | P128T-E | Human | Esophagus | ESCC | 5.02e-19 | 1.31e+00 | 0.1241 |
7018 | TF | NAFLD1 | Human | Liver | NAFLD | 1.33e-14 | 1.52e+00 | -0.04 |
7018 | TF | S43 | Human | Liver | Cirrhotic | 1.96e-06 | 4.81e-01 | -0.0187 |
7018 | TF | HCC1_Meng | Human | Liver | HCC | 7.28e-77 | 1.16e+00 | 0.0246 |
7018 | TF | HCC2_Meng | Human | Liver | HCC | 6.25e-19 | -6.79e-01 | 0.0107 |
7018 | TF | cirrhotic1 | Human | Liver | Cirrhotic | 3.69e-15 | -1.70e-01 | 0.0202 |
7018 | TF | cirrhotic2 | Human | Liver | Cirrhotic | 1.67e-15 | -1.87e-01 | 0.0201 |
7018 | TF | cirrhotic3 | Human | Liver | Cirrhotic | 2.61e-02 | -4.09e-01 | 0.0215 |
7018 | TF | HCC1 | Human | Liver | HCC | 7.61e-40 | 8.09e+00 | 0.5336 |
7018 | TF | HCC2 | Human | Liver | HCC | 6.48e-53 | 8.08e+00 | 0.5341 |
7018 | TF | HCC5 | Human | Liver | HCC | 3.83e-07 | 4.78e+00 | 0.4932 |
7018 | TF | Pt13.a | Human | Liver | HCC | 1.44e-27 | 2.57e-01 | 0.021 |
7018 | TF | Pt13.b | Human | Liver | HCC | 8.21e-34 | 3.51e-02 | 0.0251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0042060 | Colorectum | AD | wound healing | 128/3918 | 422/18723 | 2.73e-06 | 7.89e-05 | 128 |
GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
GO:0052126 | Colorectum | AD | movement in host environment | 63/3918 | 175/18723 | 2.85e-06 | 8.11e-05 | 63 |
GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
GO:0006635 | Colorectum | AD | fatty acid beta-oxidation | 33/3918 | 74/18723 | 3.98e-06 | 1.09e-04 | 33 |
GO:0009062 | Colorectum | AD | fatty acid catabolic process | 41/3918 | 100/18723 | 4.02e-06 | 1.09e-04 | 41 |
GO:0007623 | Colorectum | AD | circadian rhythm | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:1990090 | Colorectum | AD | cellular response to nerve growth factor stimulus | 26/3918 | 53/18723 | 4.87e-06 | 1.28e-04 | 26 |
GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
GO:0070059 | Colorectum | AD | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 29/3918 | 63/18723 | 7.03e-06 | 1.73e-04 | 29 |
GO:0048511 | Colorectum | AD | rhythmic process | 94/3918 | 298/18723 | 1.00e-05 | 2.34e-04 | 94 |
GO:0031667 | Colorectum | AD | response to nutrient levels | 138/3918 | 474/18723 | 1.22e-05 | 2.68e-04 | 138 |
GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
GO:0006413 | Colorectum | AD | translational initiation | 45/3918 | 118/18723 | 1.35e-05 | 2.92e-04 | 45 |
GO:0051650 | Colorectum | AD | establishment of vesicle localization | 57/3918 | 161/18723 | 1.47e-05 | 3.15e-04 | 57 |
GO:1990089 | Colorectum | AD | response to nerve growth factor | 26/3918 | 56/18723 | 1.71e-05 | 3.59e-04 | 26 |
GO:0051236 | Colorectum | AD | establishment of RNA localization | 58/3918 | 166/18723 | 1.95e-05 | 4.01e-04 | 58 |
GO:0019318 | Colorectum | AD | hexose metabolic process | 77/3918 | 237/18723 | 1.96e-05 | 4.01e-04 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0406629 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa04066113 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0421621 | Liver | Cirrhotic | Ferroptosis | 23/2530 | 41/8465 | 4.09e-04 | 2.57e-03 | 1.58e-03 | 23 |
hsa0406612 | Liver | Cirrhotic | HIF-1 signaling pathway | 46/2530 | 109/8465 | 4.00e-03 | 1.59e-02 | 9.78e-03 | 46 |
hsa0421631 | Liver | Cirrhotic | Ferroptosis | 23/2530 | 41/8465 | 4.09e-04 | 2.57e-03 | 1.58e-03 | 23 |
hsa0406613 | Liver | Cirrhotic | HIF-1 signaling pathway | 46/2530 | 109/8465 | 4.00e-03 | 1.59e-02 | 9.78e-03 | 46 |
hsa0421641 | Liver | HCC | Ferroptosis | 33/4020 | 41/8465 | 1.42e-05 | 9.88e-05 | 5.50e-05 | 33 |
hsa0406622 | Liver | HCC | HIF-1 signaling pathway | 70/4020 | 109/8465 | 2.96e-04 | 1.36e-03 | 7.57e-04 | 70 |
hsa0421651 | Liver | HCC | Ferroptosis | 33/4020 | 41/8465 | 1.42e-05 | 9.88e-05 | 5.50e-05 | 33 |
hsa0406632 | Liver | HCC | HIF-1 signaling pathway | 70/4020 | 109/8465 | 2.96e-04 | 1.36e-03 | 7.57e-04 | 70 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TF | SNV | Missense_Mutation | c.1906N>T | p.Gly636Cys | p.G636C | P02787 | protein_coding | deleterious(0.01) | possibly_damaging(0.767) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
TF | SNV | Missense_Mutation | novel | c.693N>T | p.Glu231Asp | p.E231D | P02787 | protein_coding | tolerated(0.09) | benign(0.138) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TF | SNV | Missense_Mutation | c.1009N>C | p.Glu337Gln | p.E337Q | P02787 | protein_coding | tolerated(0.24) | benign(0.03) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TF | SNV | Missense_Mutation | c.1565N>C | p.Leu522Pro | p.L522P | P02787 | protein_coding | tolerated(0.35) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TF | SNV | Missense_Mutation | novel | c.1816N>C | p.Val606Leu | p.V606L | P02787 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TF | SNV | Missense_Mutation | novel | c.1073G>T | p.Cys358Phe | p.C358F | P02787 | protein_coding | deleterious(0.05) | benign(0.097) | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TF | SNV | Missense_Mutation | novel | c.161N>T | p.Pro54Leu | p.P54L | P02787 | protein_coding | tolerated(0.06) | possibly_damaging(0.843) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TF | SNV | Missense_Mutation | c.1907N>T | p.Gly636Val | p.G636V | P02787 | protein_coding | tolerated(0.05) | benign(0.375) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TF | SNV | Missense_Mutation | c.493C>G | p.Leu165Val | p.L165V | P02787 | protein_coding | tolerated(0.45) | benign(0.035) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TF | insertion | Frame_Shift_Ins | novel | c.2011_2012insCCTCTGGGGGAACAACCACTCA | p.Gly671AlafsTer17 | p.G671Afs*17 | P02787 | protein_coding | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | adalimumab | ADALIMUMAB | 27115882 | |
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | Ademetionine | ADEMETIONINE | ||
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | CALAA-01 | |||
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | PF-06763809 | |||
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | EP-2167 |
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