![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC25A5 |
Gene summary for SLC25A5 |
![]() |
Gene information | Species | Human | Gene symbol | SLC25A5 | Gene ID | 292 |
Gene name | solute carrier family 25 member 5 | |
Gene Alias | 2F1 | |
Cytomap | Xq24 | |
Gene Type | protein-coding | GO ID | GO:0000422 | UniProtAcc | P05141 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
292 | SLC25A5 | GSM4909282 | Human | Breast | IDC | 1.72e-91 | 7.74e-01 | -0.0288 |
292 | SLC25A5 | GSM4909285 | Human | Breast | IDC | 3.62e-33 | 5.55e-01 | 0.21 |
292 | SLC25A5 | GSM4909286 | Human | Breast | IDC | 1.46e-08 | -1.30e-01 | 0.1081 |
292 | SLC25A5 | GSM4909287 | Human | Breast | IDC | 4.02e-02 | -2.84e-01 | 0.2057 |
292 | SLC25A5 | GSM4909292 | Human | Breast | IDC | 5.48e-05 | -7.79e-01 | 0.1236 |
292 | SLC25A5 | GSM4909293 | Human | Breast | IDC | 2.49e-12 | -3.55e-01 | 0.1581 |
292 | SLC25A5 | GSM4909294 | Human | Breast | IDC | 1.36e-10 | -2.46e-01 | 0.2022 |
292 | SLC25A5 | GSM4909296 | Human | Breast | IDC | 2.82e-23 | 1.29e-01 | 0.1524 |
292 | SLC25A5 | GSM4909297 | Human | Breast | IDC | 1.29e-29 | -3.74e-01 | 0.1517 |
292 | SLC25A5 | GSM4909298 | Human | Breast | IDC | 6.78e-10 | -2.90e-01 | 0.1551 |
292 | SLC25A5 | GSM4909301 | Human | Breast | IDC | 7.92e-15 | -4.64e-01 | 0.1577 |
292 | SLC25A5 | GSM4909302 | Human | Breast | IDC | 2.02e-03 | -2.79e-01 | 0.1545 |
292 | SLC25A5 | GSM4909306 | Human | Breast | IDC | 6.88e-04 | 2.85e-01 | 0.1564 |
292 | SLC25A5 | GSM4909308 | Human | Breast | IDC | 7.66e-04 | 3.00e-01 | 0.158 |
292 | SLC25A5 | GSM4909309 | Human | Breast | IDC | 2.93e-04 | -2.76e-01 | 0.0483 |
292 | SLC25A5 | GSM4909311 | Human | Breast | IDC | 5.42e-60 | -5.35e-01 | 0.1534 |
292 | SLC25A5 | GSM4909312 | Human | Breast | IDC | 1.79e-14 | -6.07e-04 | 0.1552 |
292 | SLC25A5 | GSM4909313 | Human | Breast | IDC | 1.12e-02 | -2.08e-01 | 0.0391 |
292 | SLC25A5 | GSM4909315 | Human | Breast | IDC | 1.57e-14 | -4.73e-01 | 0.21 |
292 | SLC25A5 | GSM4909316 | Human | Breast | IDC | 7.80e-05 | -4.13e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19021101 | Stomach | CAG with IM | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 8/1050 | 38/18723 | 1.03e-03 | 1.29e-02 | 8 |
GO:003021811 | Stomach | CAG with IM | erythrocyte differentiation | 16/1050 | 120/18723 | 1.09e-03 | 1.33e-02 | 16 |
GO:19057101 | Stomach | CAG with IM | positive regulation of membrane permeability | 9/1050 | 48/18723 | 1.23e-03 | 1.48e-02 | 9 |
GO:009055911 | Stomach | CAG with IM | regulation of membrane permeability | 12/1050 | 78/18723 | 1.28e-03 | 1.53e-02 | 12 |
GO:004887211 | Stomach | CAG with IM | homeostasis of number of cells | 28/1050 | 272/18723 | 1.45e-03 | 1.65e-02 | 28 |
GO:19026861 | Stomach | CAG with IM | mitochondrial outer membrane permeabilization involved in programmed cell death | 8/1050 | 40/18723 | 1.47e-03 | 1.67e-02 | 8 |
GO:19021081 | Stomach | CAG with IM | regulation of mitochondrial membrane permeability involved in apoptotic process | 8/1050 | 45/18723 | 3.22e-03 | 2.96e-02 | 8 |
GO:190260021 | Stomach | CSG | proton transmembrane transport | 34/1034 | 157/18723 | 4.69e-12 | 1.55e-09 | 34 |
GO:200123321 | Stomach | CSG | regulation of apoptotic signaling pathway | 52/1034 | 356/18723 | 1.25e-10 | 2.21e-08 | 52 |
GO:000683921 | Stomach | CSG | mitochondrial transport | 42/1034 | 254/18723 | 1.61e-10 | 2.75e-08 | 42 |
GO:200123421 | Stomach | CSG | negative regulation of apoptotic signaling pathway | 37/1034 | 224/18723 | 2.04e-09 | 2.47e-07 | 37 |
GO:000863721 | Stomach | CSG | apoptotic mitochondrial changes | 21/1034 | 107/18723 | 3.32e-07 | 2.02e-05 | 21 |
GO:199054221 | Stomach | CSG | mitochondrial transmembrane transport | 20/1034 | 102/18723 | 6.40e-07 | 3.53e-05 | 20 |
GO:001082121 | Stomach | CSG | regulation of mitochondrion organization | 21/1034 | 144/18723 | 4.29e-05 | 1.12e-03 | 21 |
GO:000226221 | Stomach | CSG | myeloid cell homeostasis | 22/1034 | 157/18723 | 5.30e-05 | 1.35e-03 | 22 |
GO:001082321 | Stomach | CSG | negative regulation of mitochondrion organization | 11/1034 | 49/18723 | 5.80e-05 | 1.46e-03 | 11 |
GO:000700621 | Stomach | CSG | mitochondrial membrane organization | 18/1034 | 116/18723 | 6.51e-05 | 1.61e-03 | 18 |
GO:003410121 | Stomach | CSG | erythrocyte homeostasis | 19/1034 | 129/18723 | 8.53e-05 | 2.01e-03 | 19 |
GO:19010282 | Stomach | CSG | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 7/1034 | 21/18723 | 9.01e-05 | 2.07e-03 | 7 |
GO:004690221 | Stomach | CSG | regulation of mitochondrial membrane permeability | 12/1034 | 63/18723 | 1.48e-04 | 3.03e-03 | 12 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501714 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa042189 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0516618 | Breast | Precancer | Human T-cell leukemia virus 1 infection | 33/684 | 222/8465 | 4.29e-04 | 3.31e-03 | 2.53e-03 | 33 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501715 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0421814 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0516619 | Breast | Precancer | Human T-cell leukemia virus 1 infection | 33/684 | 222/8465 | 4.29e-04 | 3.31e-03 | 2.53e-03 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A5 | insertion | Frame_Shift_Ins | novel | c.249_250insA | p.Thr84AsnfsTer5 | p.T84Nfs*5 | P05141 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC25A5 | SNV | Missense_Mutation | novel | c.618N>T | p.Lys206Asn | p.K206N | P05141 | protein_coding | deleterious(0.05) | benign(0.033) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC25A5 | SNV | Missense_Mutation | c.858N>G | p.Phe286Leu | p.F286L | P05141 | protein_coding | tolerated(1) | benign(0.003) | TCGA-C5-A2M2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC25A5 | SNV | Missense_Mutation | novel | c.839N>A | p.Arg280Lys | p.R280K | P05141 | protein_coding | deleterious(0.01) | possibly_damaging(0.532) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
SLC25A5 | SNV | Missense_Mutation | c.439N>G | p.Lys147Glu | p.K147E | P05141 | protein_coding | deleterious(0) | possibly_damaging(0.488) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
SLC25A5 | SNV | Missense_Mutation | c.317G>T | p.Arg106Ile | p.R106I | P05141 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
SLC25A5 | SNV | Missense_Mutation | c.91N>T | p.Arg31Trp | p.R31W | P05141 | protein_coding | tolerated(0.09) | benign(0.209) | TCGA-CM-6678-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
SLC25A5 | SNV | Missense_Mutation | c.703N>T | p.Arg235Cys | p.R235C | P05141 | protein_coding | deleterious(0.05) | possibly_damaging(0.835) | TCGA-D5-6541-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SLC25A5 | SNV | Missense_Mutation | novel | c.288N>T | p.Lys96Asn | p.K96N | P05141 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC25A5 | SNV | Missense_Mutation | c.703C>T | p.Arg235Cys | p.R235C | P05141 | protein_coding | deleterious(0.05) | possibly_damaging(0.835) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
292 | SLC25A5 | DRUGGABLE GENOME, TRANSPORTER | CLODRONATE | CLODRONIC ACID | ||
292 | SLC25A5 | DRUGGABLE GENOME, TRANSPORTER | TRICHOSTATIN A | 10657244 | ||
292 | SLC25A5 | DRUGGABLE GENOME, TRANSPORTER | BUTYRATE | 10657244 |
Page: 1 |