Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/SDCBP_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SDCBP_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SDCBP_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SDCBP_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/SDCBP_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SDCBP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/SDCBP_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SDCBP_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SDCBP_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SDCBP_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SDCBP_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SDCBP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00098956 | Stomach | GC | negative regulation of catabolic process | 32/1159 | 320/18723 | 5.15e-03 | 4.06e-02 | 32 |
GO:004586111 | Stomach | CAG with IM | negative regulation of proteolysis | 45/1050 | 351/18723 | 1.90e-07 | 1.24e-05 | 45 |
GO:004217611 | Stomach | CAG with IM | regulation of protein catabolic process | 44/1050 | 391/18723 | 8.71e-06 | 2.99e-04 | 44 |
GO:190336211 | Stomach | CAG with IM | regulation of cellular protein catabolic process | 32/1050 | 255/18723 | 1.69e-05 | 5.30e-04 | 32 |
GO:003287211 | Stomach | CAG with IM | regulation of stress-activated MAPK cascade | 25/1050 | 192/18723 | 7.51e-05 | 1.78e-03 | 25 |
GO:007030211 | Stomach | CAG with IM | regulation of stress-activated protein kinase signaling cascade | 25/1050 | 195/18723 | 9.68e-05 | 2.19e-03 | 25 |
GO:200005811 | Stomach | CAG with IM | regulation of ubiquitin-dependent protein catabolic process | 22/1050 | 164/18723 | 1.28e-04 | 2.64e-03 | 22 |
GO:003109811 | Stomach | CAG with IM | stress-activated protein kinase signaling cascade | 29/1050 | 247/18723 | 1.37e-04 | 2.79e-03 | 29 |
GO:003243411 | Stomach | CAG with IM | regulation of proteasomal ubiquitin-dependent protein catabolic process | 19/1050 | 134/18723 | 1.74e-04 | 3.33e-03 | 19 |
GO:005140311 | Stomach | CAG with IM | stress-activated MAPK cascade | 28/1050 | 239/18723 | 1.84e-04 | 3.49e-03 | 28 |
GO:190305011 | Stomach | CAG with IM | regulation of proteolysis involved in cellular protein catabolic process | 26/1050 | 221/18723 | 2.88e-04 | 4.99e-03 | 26 |
GO:003133011 | Stomach | CAG with IM | negative regulation of cellular catabolic process | 29/1050 | 262/18723 | 3.76e-04 | 6.04e-03 | 29 |
GO:000660511 | Stomach | CAG with IM | protein targeting | 33/1050 | 314/18723 | 3.98e-04 | 6.38e-03 | 33 |
GO:006113611 | Stomach | CAG with IM | regulation of proteasomal protein catabolic process | 22/1050 | 187/18723 | 8.18e-04 | 1.08e-02 | 22 |
GO:200005911 | Stomach | CAG with IM | negative regulation of ubiquitin-dependent protein catabolic process | 9/1050 | 48/18723 | 1.23e-03 | 1.48e-02 | 9 |
GO:00104986 | Stomach | CAG with IM | proteasomal protein catabolic process | 44/1050 | 490/18723 | 1.43e-03 | 1.64e-02 | 44 |
GO:000989511 | Stomach | CAG with IM | negative regulation of catabolic process | 31/1050 | 320/18723 | 2.20e-03 | 2.24e-02 | 31 |
GO:003432911 | Stomach | CAG with IM | cell junction assembly | 38/1050 | 420/18723 | 2.56e-03 | 2.50e-02 | 38 |
GO:00421776 | Stomach | CAG with IM | negative regulation of protein catabolic process | 15/1050 | 121/18723 | 3.17e-03 | 2.95e-02 | 15 |
GO:00463282 | Stomach | CAG with IM | regulation of JNK cascade | 16/1050 | 133/18723 | 3.19e-03 | 2.96e-02 | 16 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SDCBP | SNV | Missense_Mutation | | c.263N>T | p.Arg88Leu | p.R88L | | protein_coding | tolerated(0.11) | benign(0.246) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
SDCBP | SNV | Missense_Mutation | | c.574N>C | p.Asp192His | p.D192H | | protein_coding | deleterious(0.03) | possibly_damaging(0.845) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
SDCBP | SNV | Missense_Mutation | rs769061064 | c.893N>C | p.Ile298Thr | p.I298T | | protein_coding | deleterious(0) | benign(0.197) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SDCBP | SNV | Missense_Mutation | | c.274N>T | p.Ala92Ser | p.A92S | | protein_coding | tolerated(0.54) | benign(0.042) | TCGA-JW-A69B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SDCBP | SNV | Missense_Mutation | novel | c.128N>G | p.Phe43Cys | p.F43C | | protein_coding | tolerated(0.15) | possibly_damaging(0.831) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SDCBP | SNV | Missense_Mutation | novel | c.68C>A | p.Ser23Tyr | p.S23Y | | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SDCBP | SNV | Missense_Mutation | novel | c.125C>A | p.Ala42Asp | p.A42D | | protein_coding | tolerated(0.22) | benign(0.287) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SDCBP | SNV | Missense_Mutation | novel | c.16A>G | p.Thr6Ala | p.T6A | | protein_coding | tolerated_low_confidence(1) | unknown(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SDCBP | SNV | Missense_Mutation | novel | c.220C>T | p.Leu74Phe | p.L74F | | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SDCBP | SNV | Missense_Mutation | novel | c.886N>A | p.Glu296Lys | p.E296K | | protein_coding | tolerated(0.09) | benign(0.326) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |