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Gene: REL |
Gene summary for REL |
Gene summary. |
Gene information | Species | Human | Gene symbol | REL | Gene ID | 5966 |
Gene name | REL proto-oncogene, NF-kB subunit | |
Gene Alias | C-Rel | |
Cytomap | 2p16.1 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | Q04864 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5966 | REL | CA_HPV_1 | Human | Cervix | CC | 3.81e-02 | 9.14e-02 | 0.0264 |
5966 | REL | CA_HPV_2 | Human | Cervix | CC | 1.51e-02 | 3.59e-01 | 0.0391 |
5966 | REL | CA_HPV_3 | Human | Cervix | CC | 3.90e-08 | -1.87e-01 | 0.0414 |
5966 | REL | CCII_1 | Human | Cervix | CC | 2.39e-06 | -5.04e-01 | 0.3249 |
5966 | REL | sample3 | Human | Cervix | CC | 5.02e-08 | -1.98e-01 | 0.1387 |
5966 | REL | H2 | Human | Cervix | HSIL_HPV | 3.62e-02 | -3.34e-01 | 0.0632 |
5966 | REL | L1 | Human | Cervix | CC | 8.20e-12 | -5.76e-01 | 0.0802 |
5966 | REL | T3 | Human | Cervix | CC | 1.67e-05 | -1.95e-01 | 0.1389 |
5966 | REL | LZE2D | Human | Esophagus | HGIN | 6.52e-03 | 8.88e-01 | 0.0642 |
5966 | REL | LZE4T | Human | Esophagus | ESCC | 5.80e-37 | 1.46e+00 | 0.0811 |
5966 | REL | LZE5T | Human | Esophagus | ESCC | 3.10e-07 | 7.49e-01 | 0.0514 |
5966 | REL | LZE7T | Human | Esophagus | ESCC | 1.73e-18 | 1.10e+00 | 0.0667 |
5966 | REL | LZE8T | Human | Esophagus | ESCC | 4.14e-15 | 7.71e-01 | 0.067 |
5966 | REL | LZE20T | Human | Esophagus | ESCC | 1.86e-03 | 4.49e-01 | 0.0662 |
5966 | REL | LZE22D1 | Human | Esophagus | HGIN | 5.12e-07 | 1.44e-01 | 0.0595 |
5966 | REL | LZE22T | Human | Esophagus | ESCC | 1.52e-05 | 3.68e-01 | 0.068 |
5966 | REL | LZE24T | Human | Esophagus | ESCC | 4.25e-25 | 6.60e-01 | 0.0596 |
5966 | REL | LZE21T | Human | Esophagus | ESCC | 4.73e-15 | 1.25e+00 | 0.0655 |
5966 | REL | LZE6T | Human | Esophagus | ESCC | 4.59e-05 | 5.02e-01 | 0.0845 |
5966 | REL | P1T-E | Human | Esophagus | ESCC | 5.51e-31 | 1.82e+00 | 0.0875 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190121522 | Oral cavity | EOLP | negative regulation of neuron death | 38/2218 | 208/18723 | 4.28e-03 | 2.34e-02 | 38 |
GO:0045063 | Oral cavity | EOLP | T-helper 1 cell differentiation | 7/2218 | 20/18723 | 6.20e-03 | 3.09e-02 | 7 |
GO:0032480 | Oral cavity | EOLP | negative regulation of type I interferon production | 9/2218 | 30/18723 | 6.33e-03 | 3.13e-02 | 9 |
GO:00024604 | Oral cavity | EOLP | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | 58/2218 | 356/18723 | 7.27e-03 | 3.52e-02 | 58 |
GO:000183624 | Oral cavity | EOLP | release of cytochrome c from mitochondria | 14/2218 | 59/18723 | 7.86e-03 | 3.74e-02 | 14 |
GO:00022744 | Oral cavity | EOLP | myeloid leukocyte activation | 39/2218 | 223/18723 | 8.09e-03 | 3.82e-02 | 39 |
GO:200123334 | Oral cavity | NEOLP | regulation of apoptotic signaling pathway | 94/2005 | 356/18723 | 4.19e-17 | 3.11e-14 | 94 |
GO:005254733 | Oral cavity | NEOLP | regulation of peptidase activity | 98/2005 | 461/18723 | 1.77e-11 | 2.56e-09 | 98 |
GO:200123433 | Oral cavity | NEOLP | negative regulation of apoptotic signaling pathway | 59/2005 | 224/18723 | 3.40e-11 | 4.59e-09 | 59 |
GO:003009932 | Oral cavity | NEOLP | myeloid cell differentiation | 83/2005 | 381/18723 | 1.79e-10 | 1.69e-08 | 83 |
GO:006219733 | Oral cavity | NEOLP | cellular response to chemical stress | 75/2005 | 337/18723 | 4.87e-10 | 3.97e-08 | 75 |
GO:004586233 | Oral cavity | NEOLP | positive regulation of proteolysis | 80/2005 | 372/18723 | 7.28e-10 | 5.54e-08 | 80 |
GO:005254833 | Oral cavity | NEOLP | regulation of endopeptidase activity | 88/2005 | 432/18723 | 1.82e-09 | 1.18e-07 | 88 |
GO:004312231 | Oral cavity | NEOLP | regulation of I-kappaB kinase/NF-kappaB signaling | 58/2005 | 249/18723 | 7.81e-09 | 4.09e-07 | 58 |
GO:000724931 | Oral cavity | NEOLP | I-kappaB kinase/NF-kappaB signaling | 62/2005 | 281/18723 | 2.16e-08 | 9.59e-07 | 62 |
GO:004312331 | Oral cavity | NEOLP | positive regulation of I-kappaB kinase/NF-kappaB signaling | 43/2005 | 186/18723 | 8.08e-07 | 2.21e-05 | 43 |
GO:004851122 | Oral cavity | NEOLP | rhythmic process | 60/2005 | 298/18723 | 1.02e-06 | 2.72e-05 | 60 |
GO:004533332 | Oral cavity | NEOLP | cellular respiration | 49/2005 | 230/18723 | 1.85e-06 | 4.45e-05 | 49 |
GO:004211031 | Oral cavity | NEOLP | T cell activation | 86/2005 | 487/18723 | 2.01e-06 | 4.77e-05 | 86 |
GO:190313122 | Oral cavity | NEOLP | mononuclear cell differentiation | 77/2005 | 426/18723 | 2.80e-06 | 6.41e-05 | 77 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa040142 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa0401411 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa052039 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0520315 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa05203 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa052031 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa052034 | Lung | IAC | Viral carcinogenesis | 43/1053 | 204/8465 | 3.02e-04 | 3.07e-03 | 2.04e-03 | 43 |
hsa052026 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa0520311 | Lung | IAC | Viral carcinogenesis | 43/1053 | 204/8465 | 3.02e-04 | 3.07e-03 | 2.04e-03 | 43 |
hsa0520211 | Lung | IAC | Transcriptional misregulation in cancer | 40/1053 | 193/8465 | 6.90e-04 | 5.90e-03 | 3.92e-03 | 40 |
hsa052022 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa0520321 | Lung | AIS | Viral carcinogenesis | 37/961 | 204/8465 | 2.49e-03 | 1.49e-02 | 9.55e-03 | 37 |
hsa052023 | Lung | AIS | Transcriptional misregulation in cancer | 39/961 | 193/8465 | 2.15e-04 | 2.41e-03 | 1.54e-03 | 39 |
hsa0520331 | Lung | AIS | Viral carcinogenesis | 37/961 | 204/8465 | 2.49e-03 | 1.49e-02 | 9.55e-03 | 37 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
REL | SNV | Missense_Mutation | rs758702004 | c.392N>G | p.Asn131Ser | p.N131S | Q04864 | protein_coding | tolerated(0.14) | benign(0.012) | TCGA-A7-A3IZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
REL | SNV | Missense_Mutation | novel | c.279T>G | p.Phe93Leu | p.F93L | Q04864 | protein_coding | tolerated(0.46) | probably_damaging(0.92) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
REL | SNV | Missense_Mutation | c.1066N>A | p.Glu356Lys | p.E356K | Q04864 | protein_coding | deleterious(0) | possibly_damaging(0.629) | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
REL | insertion | Frame_Shift_Ins | novel | c.728_729insCACCAGATTAATC | p.Phe244ThrfsTer29 | p.F244Tfs*29 | Q04864 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
REL | insertion | In_Frame_Ins | novel | c.1828_1829insGCCTACAGGGGTTTCAAGTCAAGCAGAATCCTACTATCCCTC | p.Asp610delinsGlyLeuGlnGlyPheGlnValLysGlnAsnProThrIleProHis | p.D610delinsGLQGFQVKQNPTIPH | Q04864 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
REL | SNV | Missense_Mutation | novel | c.65G>A | p.Arg22His | p.R22H | Q04864 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
REL | SNV | Missense_Mutation | c.469N>G | p.Pro157Ala | p.P157A | Q04864 | protein_coding | tolerated(0.11) | benign(0.127) | TCGA-C5-A1M8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
REL | SNV | Missense_Mutation | c.607N>A | p.Glu203Lys | p.E203K | Q04864 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
REL | SNV | Missense_Mutation | c.946N>A | p.Asp316Asn | p.D316N | Q04864 | protein_coding | tolerated_low_confidence(0.61) | benign(0) | TCGA-JW-A852-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
REL | SNV | Missense_Mutation | c.1722N>A | p.Met574Ile | p.M574I | Q04864 | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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