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Gene: PLEC |
Gene summary for PLEC |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PLEC | Gene ID | 5339 |
| Gene name | plectin | |
| Gene Alias | EBS1 | |
| Cytomap | 8q24.3 | |
| Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q15149 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 5339 | PLEC | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.08e-04 | 1.89e-01 | 0.0155 |
| 5339 | PLEC | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.71e-29 | 1.45e+00 | -0.1808 |
| 5339 | PLEC | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.33e-10 | 6.94e-01 | -0.0811 |
| 5339 | PLEC | HTA11_78_2000001011 | Human | Colorectum | AD | 4.24e-03 | 3.71e-01 | -0.1088 |
| 5339 | PLEC | HTA11_347_2000001011 | Human | Colorectum | AD | 5.76e-22 | 6.54e-01 | -0.1954 |
| 5339 | PLEC | HTA11_411_2000001011 | Human | Colorectum | SER | 2.24e-08 | 1.69e+00 | -0.2602 |
| 5339 | PLEC | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.17e-06 | 1.25e+00 | -0.2196 |
| 5339 | PLEC | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.56e-09 | 7.41e-01 | -0.1207 |
| 5339 | PLEC | HTA11_696_2000001011 | Human | Colorectum | AD | 3.82e-13 | 6.87e-01 | -0.1464 |
| 5339 | PLEC | HTA11_866_2000001011 | Human | Colorectum | AD | 1.92e-05 | 3.40e-01 | -0.1001 |
| 5339 | PLEC | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.86e-09 | 6.64e-01 | -0.059 |
| 5339 | PLEC | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.26e-02 | 4.57e-01 | -0.2061 |
| 5339 | PLEC | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.41e-02 | 4.13e-01 | 0.0528 |
| 5339 | PLEC | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.76e-02 | 6.26e-01 | -0.0177 |
| 5339 | PLEC | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.02e-10 | 4.81e-01 | 0.0674 |
| 5339 | PLEC | HTA11_7469_2000001011 | Human | Colorectum | AD | 6.23e-06 | 6.30e-01 | -0.0124 |
| 5339 | PLEC | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.36e-15 | 7.26e-01 | 0.3859 |
| 5339 | PLEC | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.10e-10 | 4.77e-01 | 0.3005 |
| 5339 | PLEC | A015-C-203 | Human | Colorectum | FAP | 5.95e-04 | 1.32e-01 | -0.1294 |
| 5339 | PLEC | A015-C-104 | Human | Colorectum | FAP | 9.51e-05 | 1.01e-01 | -0.1899 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000961225 | Thyroid | ATC | response to mechanical stimulus | 105/6293 | 216/18723 | 3.29e-06 | 3.70e-05 | 105 |
| GO:007126022 | Thyroid | ATC | cellular response to mechanical stimulus | 46/6293 | 81/18723 | 1.51e-05 | 1.41e-04 | 46 |
| GO:001470622 | Thyroid | ATC | striated muscle tissue development | 168/6293 | 384/18723 | 1.91e-05 | 1.73e-04 | 168 |
| GO:000110124 | Thyroid | ATC | response to acid chemical | 69/6293 | 135/18723 | 1.95e-05 | 1.76e-04 | 69 |
| GO:003440512 | Thyroid | ATC | response to fluid shear stress | 24/6293 | 35/18723 | 2.49e-05 | 2.16e-04 | 24 |
| GO:000206428 | Thyroid | ATC | epithelial cell development | 103/6293 | 220/18723 | 3.06e-05 | 2.55e-04 | 103 |
| GO:004269216 | Thyroid | ATC | muscle cell differentiation | 165/6293 | 384/18723 | 7.17e-05 | 5.46e-04 | 165 |
| GO:000699714 | Thyroid | ATC | nucleus organization | 65/6293 | 133/18723 | 1.87e-04 | 1.26e-03 | 65 |
| GO:007122922 | Thyroid | ATC | cellular response to acid chemical | 42/6293 | 80/18723 | 3.75e-04 | 2.29e-03 | 42 |
| GO:000751716 | Thyroid | ATC | muscle organ development | 139/6293 | 327/18723 | 4.45e-04 | 2.64e-03 | 139 |
| GO:004873811 | Thyroid | ATC | cardiac muscle tissue development | 103/6293 | 236/18723 | 7.93e-04 | 4.37e-03 | 103 |
| GO:004206323 | Thyroid | ATC | gliogenesis | 127/6293 | 301/18723 | 1.07e-03 | 5.66e-03 | 127 |
| GO:00425526 | Thyroid | ATC | myelination | 62/6293 | 134/18723 | 1.54e-03 | 7.84e-03 | 62 |
| GO:003526414 | Thyroid | ATC | multicellular organism growth | 61/6293 | 132/18723 | 1.73e-03 | 8.66e-03 | 61 |
| GO:005114617 | Thyroid | ATC | striated muscle cell differentiation | 119/6293 | 283/18723 | 1.74e-03 | 8.70e-03 | 119 |
| GO:007058413 | Thyroid | ATC | mitochondrion morphogenesis | 14/6293 | 21/18723 | 1.99e-03 | 9.54e-03 | 14 |
| GO:007149811 | Thyroid | ATC | cellular response to fluid shear stress | 14/6293 | 21/18723 | 1.99e-03 | 9.54e-03 | 14 |
| GO:005500112 | Thyroid | ATC | muscle cell development | 81/6293 | 184/18723 | 2.02e-03 | 9.60e-03 | 81 |
| GO:003505111 | Thyroid | ATC | cardiocyte differentiation | 70/6293 | 156/18723 | 2.18e-03 | 1.02e-02 | 70 |
| GO:00072726 | Thyroid | ATC | ensheathment of neurons | 62/6293 | 136/18723 | 2.39e-03 | 1.11e-02 | 62 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PLEC | SNV | Missense_Mutation | c.4341N>C | p.Glu1447Asp | p.E1447D | Q15149 | protein_coding | tolerated(1) | benign(0) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| PLEC | SNV | Missense_Mutation | c.10135N>G | p.Pro3379Ala | p.P3379A | Q15149 | protein_coding | tolerated(0.06) | benign(0.006) | TCGA-A2-A0T0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD | |
| PLEC | SNV | Missense_Mutation | c.8535G>C | p.Glu2845Asp | p.E2845D | Q15149 | protein_coding | deleterious(0.02) | benign(0.026) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| PLEC | SNV | Missense_Mutation | rs368982802 | c.10961N>T | p.Thr3654Met | p.T3654M | Q15149 | protein_coding | deleterious(0) | probably_damaging(0.926) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLEC | SNV | Missense_Mutation | c.2672N>G | p.Ser891Cys | p.S891C | Q15149 | protein_coding | deleterious(0) | benign(0.139) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| PLEC | SNV | Missense_Mutation | novel | c.8752N>C | p.Tyr2918His | p.Y2918H | Q15149 | protein_coding | deleterious(0.04) | possibly_damaging(0.853) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| PLEC | SNV | Missense_Mutation | c.1230G>T | p.Arg410Ser | p.R410S | Q15149 | protein_coding | tolerated(0.72) | benign(0.001) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| PLEC | SNV | Missense_Mutation | rs782166303 | c.172C>T | p.Arg58Trp | p.R58W | Q15149 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLEC | SNV | Missense_Mutation | novel | c.934N>G | p.Tyr312Asp | p.Y312D | Q15149 | protein_coding | deleterious(0) | possibly_damaging(0.615) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| PLEC | SNV | Missense_Mutation | novel | c.4297G>T | p.Val1433Leu | p.V1433L | Q15149 | protein_coding | tolerated(0.81) | benign(0) | TCGA-BH-A42T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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