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Gene: HK1 |
Gene summary for HK1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | HK1 | Gene ID | 3098 |
Gene name | hexokinase 1 | |
Gene Alias | HK | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001678 | UniProtAcc | A8K7J7 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3098 | HK1 | CCI_1 | Human | Cervix | CC | 2.98e-02 | 5.23e-01 | 0.528 |
3098 | HK1 | CCI_2 | Human | Cervix | CC | 6.13e-09 | 7.87e-01 | 0.5249 |
3098 | HK1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.73e-05 | 3.75e-01 | -0.1954 |
3098 | HK1 | A015-C-203 | Human | Colorectum | FAP | 5.47e-13 | -3.85e-01 | -0.1294 |
3098 | HK1 | A015-C-204 | Human | Colorectum | FAP | 5.49e-03 | -2.56e-01 | -0.0228 |
3098 | HK1 | A014-C-040 | Human | Colorectum | FAP | 1.49e-02 | -3.87e-01 | -0.1184 |
3098 | HK1 | A002-C-201 | Human | Colorectum | FAP | 3.98e-10 | -2.88e-01 | 0.0324 |
3098 | HK1 | A001-C-119 | Human | Colorectum | FAP | 1.59e-03 | -2.66e-01 | -0.1557 |
3098 | HK1 | A001-C-108 | Human | Colorectum | FAP | 4.60e-04 | -2.25e-01 | -0.0272 |
3098 | HK1 | A002-C-205 | Human | Colorectum | FAP | 2.21e-12 | -2.50e-01 | -0.1236 |
3098 | HK1 | A015-C-005 | Human | Colorectum | FAP | 1.17e-03 | -2.68e-01 | -0.0336 |
3098 | HK1 | A015-C-006 | Human | Colorectum | FAP | 1.80e-07 | -2.70e-01 | -0.0994 |
3098 | HK1 | A015-C-106 | Human | Colorectum | FAP | 6.60e-05 | -2.11e-01 | -0.0511 |
3098 | HK1 | A002-C-114 | Human | Colorectum | FAP | 6.04e-11 | -3.02e-01 | -0.1561 |
3098 | HK1 | A015-C-104 | Human | Colorectum | FAP | 2.93e-13 | -3.88e-01 | -0.1899 |
3098 | HK1 | A001-C-014 | Human | Colorectum | FAP | 2.99e-03 | -2.30e-01 | 0.0135 |
3098 | HK1 | A002-C-016 | Human | Colorectum | FAP | 1.38e-08 | -2.76e-01 | 0.0521 |
3098 | HK1 | A015-C-002 | Human | Colorectum | FAP | 8.17e-07 | -3.08e-01 | -0.0763 |
3098 | HK1 | A001-C-203 | Human | Colorectum | FAP | 8.29e-04 | -1.62e-01 | -0.0481 |
3098 | HK1 | A002-C-116 | Human | Colorectum | FAP | 7.19e-14 | -2.75e-01 | -0.0452 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009150112 | Skin | cSCC | purine ribonucleotide metabolic process | 131/4864 | 368/18723 | 2.42e-05 | 2.76e-04 | 131 |
GO:004814422 | Skin | cSCC | fibroblast proliferation | 38/4864 | 81/18723 | 3.88e-05 | 4.17e-04 | 38 |
GO:0034614111 | Skin | cSCC | cellular response to reactive oxygen species | 63/4864 | 155/18723 | 4.50e-05 | 4.72e-04 | 63 |
GO:003109825 | Skin | cSCC | stress-activated protein kinase signaling cascade | 92/4864 | 247/18723 | 5.78e-05 | 5.74e-04 | 92 |
GO:004814522 | Skin | cSCC | regulation of fibroblast proliferation | 37/4864 | 80/18723 | 7.15e-05 | 6.87e-04 | 37 |
GO:005140325 | Skin | cSCC | stress-activated MAPK cascade | 88/4864 | 239/18723 | 1.32e-04 | 1.20e-03 | 88 |
GO:007030225 | Skin | cSCC | regulation of stress-activated protein kinase signaling cascade | 74/4864 | 195/18723 | 1.50e-04 | 1.33e-03 | 74 |
GO:000155824 | Skin | cSCC | regulation of cell growth | 140/4864 | 414/18723 | 2.07e-04 | 1.72e-03 | 140 |
GO:00610255 | Skin | cSCC | membrane fusion | 63/4864 | 163/18723 | 2.49e-04 | 2.03e-03 | 63 |
GO:003287225 | Skin | cSCC | regulation of stress-activated MAPK cascade | 72/4864 | 192/18723 | 2.76e-04 | 2.22e-03 | 72 |
GO:0009132110 | Skin | cSCC | nucleoside diphosphate metabolic process | 49/4864 | 124/18723 | 6.45e-04 | 4.64e-03 | 49 |
GO:00069064 | Skin | cSCC | vesicle fusion | 43/4864 | 106/18723 | 7.14e-04 | 5.03e-03 | 43 |
GO:00901744 | Skin | cSCC | organelle membrane fusion | 44/4864 | 110/18723 | 8.82e-04 | 6.07e-03 | 44 |
GO:00703019 | Skin | cSCC | cellular response to hydrogen peroxide | 40/4864 | 98/18723 | 9.33e-04 | 6.38e-03 | 40 |
GO:003461226 | Skin | cSCC | response to tumor necrosis factor | 88/4864 | 253/18723 | 1.11e-03 | 7.31e-03 | 88 |
GO:19012248 | Skin | cSCC | positive regulation of NIK/NF-kappaB signaling | 30/4864 | 69/18723 | 1.19e-03 | 7.75e-03 | 30 |
GO:003030722 | Skin | cSCC | positive regulation of cell growth | 61/4864 | 166/18723 | 1.39e-03 | 8.78e-03 | 61 |
GO:0009185110 | Skin | cSCC | ribonucleoside diphosphate metabolic process | 42/4864 | 106/18723 | 1.42e-03 | 8.98e-03 | 42 |
GO:004693920 | Skin | cSCC | nucleotide phosphorylation | 40/4864 | 101/18723 | 1.84e-03 | 1.11e-02 | 40 |
GO:003320915 | Skin | cSCC | tumor necrosis factor-mediated signaling pathway | 39/4864 | 99/18723 | 2.33e-03 | 1.36e-02 | 39 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513120 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0406618 | Cervix | CC | HIF-1 signaling pathway | 27/1267 | 109/8465 | 4.72e-03 | 1.64e-02 | 9.72e-03 | 27 |
hsa0523010 | Cervix | CC | Central carbon metabolism in cancer | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa05131110 | Cervix | CC | Shigellosis | 69/1267 | 247/8465 | 7.64e-08 | 1.03e-06 | 6.10e-07 | 69 |
hsa0406619 | Cervix | CC | HIF-1 signaling pathway | 27/1267 | 109/8465 | 4.72e-03 | 1.64e-02 | 9.72e-03 | 27 |
hsa0523013 | Cervix | CC | Central carbon metabolism in cancer | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa052301 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa051318 | Colorectum | FAP | Shigellosis | 76/1404 | 247/8465 | 1.57e-08 | 5.84e-07 | 3.55e-07 | 76 |
hsa040666 | Colorectum | FAP | HIF-1 signaling pathway | 38/1404 | 109/8465 | 2.43e-06 | 4.28e-05 | 2.60e-05 | 38 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HK1 | SNV | Missense_Mutation | novel | c.862G>A | p.Gly288Arg | p.G288R | P19367 | protein_coding | tolerated(0.21) | probably_damaging(0.982) | TCGA-A7-A4SC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
HK1 | SNV | Missense_Mutation | c.100C>T | p.Arg34Trp | p.R34W | P19367 | protein_coding | deleterious(0.03) | probably_damaging(0.979) | TCGA-A7-A6VV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR | |
HK1 | SNV | Missense_Mutation | novel | c.2692N>C | p.Glu898Gln | p.E898Q | P19367 | protein_coding | deleterious(0.01) | probably_damaging(0.958) | TCGA-D8-A4Z1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
HK1 | deletion | Frame_Shift_Del | novel | c.797delG | p.Gly266GlufsTer9 | p.G266Efs*9 | P19367 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
HK1 | SNV | Missense_Mutation | rs747689299 | c.1414C>T | p.Arg472Trp | p.R472W | P19367 | protein_coding | deleterious(0.01) | probably_damaging(0.945) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HK1 | SNV | Missense_Mutation | rs867948527 | c.2740C>T | p.Arg914Trp | p.R914W | P19367 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HK1 | SNV | Missense_Mutation | novel | c.703G>A | p.Gly235Ser | p.G235S | P19367 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HK1 | SNV | Missense_Mutation | rs146727978 | c.2548N>T | p.Arg850Cys | p.R850C | P19367 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HK1 | SNV | Missense_Mutation | novel | c.1492G>A | p.Glu498Lys | p.E498K | P19367 | protein_coding | deleterious(0.01) | probably_damaging(0.975) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HK1 | SNV | Missense_Mutation | novel | c.932G>A | p.Arg311Gln | p.R311Q | P19367 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3098 | HK1 | ENZYME, KINASE | ADENOVIRUS VECTOR | 8804424 |
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