Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00326401 | Stomach | CAG with IM | tumor necrosis factor production | 21/1050 | 181/18723 | 1.27e-03 | 1.52e-02 | 21 |
GO:00326801 | Stomach | CAG with IM | regulation of tumor necrosis factor production | 21/1050 | 181/18723 | 1.27e-03 | 1.52e-02 | 21 |
GO:00104986 | Stomach | CAG with IM | proteasomal protein catabolic process | 44/1050 | 490/18723 | 1.43e-03 | 1.64e-02 | 44 |
GO:00712221 | Stomach | CAG with IM | cellular response to lipopolysaccharide | 23/1050 | 209/18723 | 1.56e-03 | 1.75e-02 | 23 |
GO:00717061 | Stomach | CAG with IM | tumor necrosis factor superfamily cytokine production | 21/1050 | 186/18723 | 1.79e-03 | 1.92e-02 | 21 |
GO:19035551 | Stomach | CAG with IM | regulation of tumor necrosis factor superfamily cytokine production | 21/1050 | 186/18723 | 1.79e-03 | 1.92e-02 | 21 |
GO:007005911 | Stomach | CAG with IM | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 10/1050 | 63/18723 | 2.50e-03 | 2.46e-02 | 10 |
GO:00309681 | Stomach | CAG with IM | endoplasmic reticulum unfolded protein response | 11/1050 | 74/18723 | 2.66e-03 | 2.58e-02 | 11 |
GO:000599611 | Stomach | CAG with IM | monosaccharide metabolic process | 26/1050 | 257/18723 | 2.67e-03 | 2.58e-02 | 26 |
GO:00712191 | Stomach | CAG with IM | cellular response to molecule of bacterial origin | 23/1050 | 221/18723 | 3.21e-03 | 2.96e-02 | 23 |
GO:00708731 | Stomach | CAG with IM | regulation of glycogen metabolic process | 7/1050 | 36/18723 | 3.41e-03 | 3.08e-02 | 7 |
GO:001931811 | Stomach | CAG with IM | hexose metabolic process | 24/1050 | 237/18723 | 3.77e-03 | 3.31e-02 | 24 |
GO:00431616 | Stomach | CAG with IM | proteasome-mediated ubiquitin-dependent protein catabolic process | 36/1050 | 412/18723 | 5.70e-03 | 4.45e-02 | 36 |
GO:00712161 | Stomach | CAG with IM | cellular response to biotic stimulus | 24/1050 | 246/18723 | 5.99e-03 | 4.63e-02 | 24 |
GO:000609121 | Stomach | CSG | generation of precursor metabolites and energy | 83/1034 | 490/18723 | 2.95e-20 | 3.12e-17 | 83 |
GO:001598021 | Stomach | CSG | energy derivation by oxidation of organic compounds | 63/1034 | 318/18723 | 4.03e-19 | 3.05e-16 | 63 |
GO:009875421 | Stomach | CSG | detoxification | 32/1034 | 152/18723 | 4.37e-11 | 8.90e-09 | 32 |
GO:000963621 | Stomach | CSG | response to toxic substance | 43/1034 | 262/18723 | 1.25e-10 | 2.21e-08 | 43 |
GO:200123321 | Stomach | CSG | regulation of apoptotic signaling pathway | 52/1034 | 356/18723 | 1.25e-10 | 2.21e-08 | 52 |
GO:000697921 | Stomach | CSG | response to oxidative stress | 58/1034 | 446/18723 | 1.08e-09 | 1.46e-07 | 58 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414118 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414119 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414124 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414134 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414143 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414153 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041411 | Colorectum | AD | Protein processing in endoplasmic reticulum | 80/2092 | 174/8465 | 5.96e-10 | 1.25e-08 | 7.96e-09 | 80 |
hsa041412 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041413 | Colorectum | SER | Protein processing in endoplasmic reticulum | 60/1580 | 174/8465 | 4.20e-07 | 7.33e-06 | 5.32e-06 | 60 |
hsa041414 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041415 | Colorectum | MSS | Protein processing in endoplasmic reticulum | 75/1875 | 174/8465 | 3.78e-10 | 8.44e-09 | 5.17e-09 | 75 |
hsa041418 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa041419 | Colorectum | FAP | Protein processing in endoplasmic reticulum | 50/1404 | 174/8465 | 3.64e-05 | 3.68e-04 | 2.24e-04 | 50 |
hsa0414126 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa04141111 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa0414127 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414136 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |