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Gene: PAFAH1B1 |
Gene summary for PAFAH1B1 |
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Gene information | Species | Human | Gene symbol | PAFAH1B1 | Gene ID | 5048 |
Gene name | platelet activating factor acetylhydrolase 1b regulatory subunit 1 | |
Gene Alias | LIS1 | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P43034 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5048 | PAFAH1B1 | CA_HPV_1 | Human | Cervix | CC | 7.64e-03 | -1.33e-01 | 0.0264 |
5048 | PAFAH1B1 | CA_HPV_3 | Human | Cervix | CC | 3.54e-03 | 9.12e-02 | 0.0414 |
5048 | PAFAH1B1 | N_HPV_2 | Human | Cervix | N_HPV | 3.57e-02 | 7.58e-02 | -0.0131 |
5048 | PAFAH1B1 | CCI_1 | Human | Cervix | CC | 6.23e-06 | 9.35e-01 | 0.528 |
5048 | PAFAH1B1 | CCI_2 | Human | Cervix | CC | 6.74e-08 | 1.15e+00 | 0.5249 |
5048 | PAFAH1B1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.08e-05 | -2.90e-01 | 0.0155 |
5048 | PAFAH1B1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.37e-09 | 5.75e-01 | -0.1954 |
5048 | PAFAH1B1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.33e-02 | -4.88e-01 | 0.2585 |
5048 | PAFAH1B1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.18e-02 | -2.63e-01 | 0.3005 |
5048 | PAFAH1B1 | F007 | Human | Colorectum | FAP | 1.41e-03 | -2.21e-01 | 0.1176 |
5048 | PAFAH1B1 | A002-C-010 | Human | Colorectum | FAP | 5.59e-03 | -2.39e-01 | 0.242 |
5048 | PAFAH1B1 | A001-C-207 | Human | Colorectum | FAP | 1.29e-02 | -1.27e-01 | 0.1278 |
5048 | PAFAH1B1 | A015-C-203 | Human | Colorectum | FAP | 2.48e-35 | -4.58e-01 | -0.1294 |
5048 | PAFAH1B1 | A015-C-204 | Human | Colorectum | FAP | 2.32e-09 | -3.89e-01 | -0.0228 |
5048 | PAFAH1B1 | A014-C-040 | Human | Colorectum | FAP | 2.33e-04 | -3.02e-01 | -0.1184 |
5048 | PAFAH1B1 | A002-C-201 | Human | Colorectum | FAP | 3.37e-16 | -3.89e-01 | 0.0324 |
5048 | PAFAH1B1 | A002-C-203 | Human | Colorectum | FAP | 2.33e-08 | -3.22e-01 | 0.2786 |
5048 | PAFAH1B1 | A001-C-119 | Human | Colorectum | FAP | 1.64e-09 | -2.88e-01 | -0.1557 |
5048 | PAFAH1B1 | A001-C-108 | Human | Colorectum | FAP | 9.52e-20 | -2.40e-01 | -0.0272 |
5048 | PAFAH1B1 | A002-C-205 | Human | Colorectum | FAP | 1.05e-27 | -4.63e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003070510 | Oral cavity | OSCC | cytoskeleton-dependent intracellular transport | 113/7305 | 195/18723 | 6.03e-08 | 1.09e-06 | 113 |
GO:000257310 | Oral cavity | OSCC | myeloid leukocyte differentiation | 119/7305 | 208/18723 | 7.29e-08 | 1.29e-06 | 119 |
GO:004340917 | Oral cavity | OSCC | negative regulation of MAPK cascade | 105/7305 | 180/18723 | 1.10e-07 | 1.87e-06 | 105 |
GO:005165120 | Oral cavity | OSCC | maintenance of location in cell | 121/7305 | 214/18723 | 1.39e-07 | 2.32e-06 | 121 |
GO:007030210 | Oral cavity | OSCC | regulation of stress-activated protein kinase signaling cascade | 111/7305 | 195/18723 | 2.82e-07 | 4.34e-06 | 111 |
GO:00085449 | Oral cavity | OSCC | epidermis development | 171/7305 | 324/18723 | 2.89e-07 | 4.43e-06 | 171 |
GO:00107209 | Oral cavity | OSCC | positive regulation of cell development | 159/7305 | 298/18723 | 3.06e-07 | 4.66e-06 | 159 |
GO:002260419 | Oral cavity | OSCC | regulation of cell morphogenesis | 163/7305 | 309/18723 | 5.66e-07 | 8.19e-06 | 163 |
GO:003287210 | Oral cavity | OSCC | regulation of stress-activated MAPK cascade | 108/7305 | 192/18723 | 8.97e-07 | 1.22e-05 | 108 |
GO:00019594 | Oral cavity | OSCC | regulation of cytokine-mediated signaling pathway | 87/7305 | 150/18723 | 1.82e-06 | 2.35e-05 | 87 |
GO:003086510 | Oral cavity | OSCC | cortical cytoskeleton organization | 42/7305 | 61/18723 | 2.23e-06 | 2.84e-05 | 42 |
GO:00607594 | Oral cavity | OSCC | regulation of response to cytokine stimulus | 92/7305 | 162/18723 | 3.25e-06 | 3.90e-05 | 92 |
GO:00311226 | Oral cavity | OSCC | cytoplasmic microtubule organization | 39/7305 | 56/18723 | 3.29e-06 | 3.93e-05 | 39 |
GO:00109706 | Oral cavity | OSCC | transport along microtubule | 88/7305 | 155/18723 | 5.35e-06 | 6.02e-05 | 88 |
GO:003001016 | Oral cavity | OSCC | establishment of cell polarity | 82/7305 | 143/18723 | 6.56e-06 | 7.24e-05 | 82 |
GO:00507696 | Oral cavity | OSCC | positive regulation of neurogenesis | 120/7305 | 225/18723 | 8.45e-06 | 9.02e-05 | 120 |
GO:00705077 | Oral cavity | OSCC | regulation of microtubule cytoskeleton organization | 84/7305 | 148/18723 | 8.80e-06 | 9.33e-05 | 84 |
GO:00099139 | Oral cavity | OSCC | epidermal cell differentiation | 109/7305 | 202/18723 | 1.08e-05 | 1.14e-04 | 109 |
GO:00420635 | Oral cavity | OSCC | gliogenesis | 154/7305 | 301/18723 | 1.10e-05 | 1.14e-04 | 154 |
GO:00723845 | Oral cavity | OSCC | organelle transport along microtubule | 53/7305 | 85/18723 | 1.10e-05 | 1.14e-04 | 53 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAFAH1B1 | SNV | Missense_Mutation | c.1062N>C | p.Leu354Phe | p.L354F | P43034 | protein_coding | tolerated(0.06) | benign(0.112) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
PAFAH1B1 | SNV | Missense_Mutation | c.603N>T | p.Met201Ile | p.M201I | P43034 | protein_coding | tolerated(0.6) | benign(0.203) | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
PAFAH1B1 | SNV | Missense_Mutation | c.170N>G | p.Ser57Cys | p.S57C | P43034 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
PAFAH1B1 | deletion | Frame_Shift_Del | novel | c.1045delN | p.Lys351SerfsTer4 | p.K351Sfs*4 | P43034 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
PAFAH1B1 | SNV | Missense_Mutation | novel | c.19N>G | p.Gln7Glu | p.Q7E | P43034 | protein_coding | deleterious(0) | possibly_damaging(0.709) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PAFAH1B1 | SNV | Missense_Mutation | novel | c.1162N>G | p.Phe388Val | p.F388V | P43034 | protein_coding | tolerated(0.16) | benign(0.07) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PAFAH1B1 | SNV | Missense_Mutation | c.239N>T | p.Thr80Met | p.T80M | P43034 | protein_coding | tolerated(0.11) | benign(0.206) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PAFAH1B1 | SNV | Missense_Mutation | novel | c.212N>G | p.Lys71Arg | p.K71R | P43034 | protein_coding | tolerated(1) | benign(0.005) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PAFAH1B1 | SNV | Missense_Mutation | c.431N>A | p.Arg144Gln | p.R144Q | P43034 | protein_coding | tolerated(0.06) | benign(0.3) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PAFAH1B1 | SNV | Missense_Mutation | c.1112N>A | p.Arg371Gln | p.R371Q | P43034 | protein_coding | deleterious(0.04) | possibly_damaging(0.5) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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