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Gene: MIF |
Gene summary for MIF |
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Gene information | Species | Human | Gene symbol | MIF | Gene ID | 4282 |
Gene name | macrophage migration inhibitory factor | |
Gene Alias | GIF | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | I4AY87 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4282 | MIF | GSM4909281 | Human | Breast | IDC | 1.08e-77 | 6.83e-01 | 0.21 |
4282 | MIF | GSM4909285 | Human | Breast | IDC | 3.07e-22 | -3.93e-01 | 0.21 |
4282 | MIF | GSM4909286 | Human | Breast | IDC | 8.78e-17 | 4.21e-01 | 0.1081 |
4282 | MIF | GSM4909287 | Human | Breast | IDC | 1.14e-64 | 6.20e-01 | 0.2057 |
4282 | MIF | GSM4909288 | Human | Breast | IDC | 1.58e-02 | -2.18e-01 | 0.0988 |
4282 | MIF | GSM4909289 | Human | Breast | IDC | 8.47e-24 | 6.06e-01 | 0.1064 |
4282 | MIF | GSM4909290 | Human | Breast | IDC | 6.70e-79 | 7.59e-01 | 0.2096 |
4282 | MIF | GSM4909291 | Human | Breast | IDC | 8.23e-96 | 9.02e-01 | 0.1753 |
4282 | MIF | GSM4909292 | Human | Breast | IDC | 1.56e-10 | 4.37e-01 | 0.1236 |
4282 | MIF | GSM4909293 | Human | Breast | IDC | 8.84e-15 | -2.18e-01 | 0.1581 |
4282 | MIF | GSM4909294 | Human | Breast | IDC | 5.48e-12 | 1.47e-01 | 0.2022 |
4282 | MIF | GSM4909296 | Human | Breast | IDC | 2.28e-100 | 7.95e-01 | 0.1524 |
4282 | MIF | GSM4909297 | Human | Breast | IDC | 4.42e-22 | 9.80e-02 | 0.1517 |
4282 | MIF | GSM4909298 | Human | Breast | IDC | 1.16e-07 | 3.32e-01 | 0.1551 |
4282 | MIF | GSM4909300 | Human | Breast | IDC | 1.08e-14 | 4.42e-01 | 0.0334 |
4282 | MIF | GSM4909301 | Human | Breast | IDC | 1.40e-12 | 3.11e-01 | 0.1577 |
4282 | MIF | GSM4909302 | Human | Breast | IDC | 1.21e-18 | 2.14e-01 | 0.1545 |
4282 | MIF | GSM4909305 | Human | Breast | IDC | 4.92e-06 | 2.89e-01 | 0.0436 |
4282 | MIF | GSM4909306 | Human | Breast | IDC | 4.10e-81 | 7.13e-01 | 0.1564 |
4282 | MIF | GSM4909307 | Human | Breast | IDC | 6.23e-27 | 4.11e-01 | 0.1569 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00435184 | Skin | AK | negative regulation of DNA damage response, signal transduction by p53 class mediator | 6/1910 | 15/18723 | 2.48e-03 | 1.61e-02 | 6 |
GO:000181917 | Skin | AK | positive regulation of cytokine production | 67/1910 | 467/18723 | 2.59e-03 | 1.67e-02 | 67 |
GO:00321024 | Skin | AK | negative regulation of response to external stimulus | 61/1910 | 420/18723 | 2.96e-03 | 1.87e-02 | 61 |
GO:190216518 | Skin | AK | regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 6/1910 | 16/18723 | 3.63e-03 | 2.17e-02 | 6 |
GO:00482467 | Skin | AK | macrophage chemotaxis | 10/1910 | 38/18723 | 3.89e-03 | 2.29e-02 | 10 |
GO:00434108 | Skin | AK | positive regulation of MAPK cascade | 66/1910 | 480/18723 | 7.41e-03 | 3.78e-02 | 66 |
GO:00703717 | Skin | AK | ERK1 and ERK2 cascade | 48/1910 | 330/18723 | 7.52e-03 | 3.83e-02 | 48 |
GO:19055176 | Skin | AK | macrophage migration | 12/1910 | 55/18723 | 8.41e-03 | 4.16e-02 | 12 |
GO:19021665 | Skin | AK | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 5/1910 | 14/18723 | 1.00e-02 | 4.80e-02 | 5 |
GO:2001233112 | Skin | SCCIS | regulation of apoptotic signaling pathway | 51/919 | 356/18723 | 5.51e-12 | 7.43e-09 | 51 |
GO:0097193112 | Skin | SCCIS | intrinsic apoptotic signaling pathway | 42/919 | 288/18723 | 2.40e-10 | 2.12e-07 | 42 |
GO:2001242112 | Skin | SCCIS | regulation of intrinsic apoptotic signaling pathway | 28/919 | 164/18723 | 7.32e-09 | 2.95e-06 | 28 |
GO:003059515 | Skin | SCCIS | leukocyte chemotaxis | 33/919 | 230/18723 | 3.03e-08 | 7.00e-06 | 33 |
GO:005092012 | Skin | SCCIS | regulation of chemotaxis | 32/919 | 223/18723 | 4.88e-08 | 8.19e-06 | 32 |
GO:000268318 | Skin | SCCIS | negative regulation of immune system process | 49/919 | 434/18723 | 4.92e-08 | 8.19e-06 | 49 |
GO:005090016 | Skin | SCCIS | leukocyte migration | 44/919 | 369/18723 | 4.93e-08 | 8.19e-06 | 44 |
GO:006032615 | Skin | SCCIS | cell chemotaxis | 39/919 | 310/18723 | 6.84e-08 | 1.04e-05 | 39 |
GO:0007568110 | Skin | SCCIS | aging | 41/919 | 339/18723 | 9.54e-08 | 1.29e-05 | 41 |
GO:009752916 | Skin | SCCIS | myeloid leukocyte migration | 31/919 | 220/18723 | 1.20e-07 | 1.52e-05 | 31 |
GO:004001315 | Skin | SCCIS | negative regulation of locomotion | 44/919 | 391/18723 | 2.61e-07 | 2.61e-05 | 44 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | ADJ |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | ADJ |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | DCIS |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | DCIS |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | DCIS |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Healthy |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Healthy |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | Healthy |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | IDC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | IDC |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Precancer |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Precancer |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | ADJ |
MIF | ACKR3 | MIF_ACKR3 | MIF | Cervix | ADJ |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | CC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | CC |
MIF | ACKR3 | MIF_ACKR3 | MIF | Cervix | CC |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | Healthy |
Page: 1 2 3 4 5 6 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIF | SNV | Missense_Mutation | novel | c.266N>C | p.Arg89Pro | p.R89P | P14174 | protein_coding | tolerated(0.21) | benign(0.219) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MIF | insertion | Frame_Shift_Ins | rs767392036 | c.99_100insC | p.Gln36ProfsTer? | p.Q36Pfs*? | P14174 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIF | SNV | Missense_Mutation | novel | c.95N>A | p.Gly32Asp | p.G32D | P14174 | protein_coding | tolerated(0.06) | benign(0.136) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MIF | insertion | Frame_Shift_Ins | rs767392036 | c.99_100insC | p.Gln36ProfsTer? | p.Q36Pfs*? | P14174 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIF | SNV | Missense_Mutation | c.52N>T | p.Gly18Trp | p.G18W | P14174 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | ANTI-MIF MONOCLONAL ANTIBODY | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | COR100140 | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | PPD | 393437 | ||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | Anti-MIF antibodies | 22238348 | ||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | TCMDC-124484 | CHEMBL524449 | 21719283 | |
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | ISO-1 | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | PMA | 3305746 |
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