![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: BMP2 |
Gene summary for BMP2 |
![]() |
Gene information | Species | Human | Gene symbol | BMP2 | Gene ID | 650 |
Gene name | bone morphogenetic protein 2 | |
Gene Alias | BDA2 | |
Cytomap | 20p12.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | C8C060 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
650 | BMP2 | AEH-subject3 | Human | Endometrium | AEH | 3.87e-05 | -1.08e-01 | -0.2576 |
650 | BMP2 | AEH-subject4 | Human | Endometrium | AEH | 1.17e-02 | -1.08e-01 | -0.2657 |
650 | BMP2 | AEH-subject5 | Human | Endometrium | AEH | 3.87e-05 | -1.04e-01 | -0.2953 |
650 | BMP2 | EEC-subject3 | Human | Endometrium | EEC | 2.79e-05 | -4.58e-02 | -0.2525 |
650 | BMP2 | EEC-subject5 | Human | Endometrium | EEC | 3.71e-04 | -1.08e-01 | -0.249 |
650 | BMP2 | GSM5276934 | Human | Endometrium | EEC | 1.36e-22 | 7.64e-01 | -0.0913 |
650 | BMP2 | GSM5276937 | Human | Endometrium | EEC | 5.33e-25 | 7.57e-01 | -0.0897 |
650 | BMP2 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 4.67e-04 | -5.12e-02 | -0.1875 |
650 | BMP2 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.51e-03 | -1.08e-01 | -0.1934 |
650 | BMP2 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 8.23e-05 | -1.08e-01 | -0.1917 |
650 | BMP2 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.97e-05 | -1.08e-01 | -0.1916 |
650 | BMP2 | LZE4T | Human | Esophagus | ESCC | 1.56e-02 | -4.23e-01 | 0.0811 |
650 | BMP2 | LZE8T | Human | Esophagus | ESCC | 4.52e-06 | -3.25e-01 | 0.067 |
650 | BMP2 | LZE24T | Human | Esophagus | ESCC | 1.37e-04 | -3.50e-01 | 0.0596 |
650 | BMP2 | P2T-E | Human | Esophagus | ESCC | 1.85e-13 | -2.72e-01 | 0.1177 |
650 | BMP2 | P5T-E | Human | Esophagus | ESCC | 1.23e-02 | -1.52e-02 | 0.1327 |
650 | BMP2 | P8T-E | Human | Esophagus | ESCC | 1.55e-03 | -8.66e-02 | 0.0889 |
650 | BMP2 | P11T-E | Human | Esophagus | ESCC | 4.01e-06 | 1.32e+00 | 0.1426 |
650 | BMP2 | P12T-E | Human | Esophagus | ESCC | 4.07e-09 | -3.44e-01 | 0.1122 |
650 | BMP2 | P15T-E | Human | Esophagus | ESCC | 3.32e-02 | -3.30e-01 | 0.1149 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001649111 | Thyroid | PTC | osteoblast differentiation | 102/5968 | 229/18723 | 3.66e-05 | 3.40e-04 | 102 |
GO:004544418 | Thyroid | PTC | fat cell differentiation | 102/5968 | 229/18723 | 3.66e-05 | 3.40e-04 | 102 |
GO:004825918 | Thyroid | PTC | regulation of receptor-mediated endocytosis | 55/5968 | 110/18723 | 5.64e-05 | 4.99e-04 | 55 |
GO:005196214 | Thyroid | PTC | positive regulation of nervous system development | 117/5968 | 272/18723 | 6.72e-05 | 5.89e-04 | 117 |
GO:001092116 | Thyroid | PTC | regulation of phosphatase activity | 44/5968 | 84/18723 | 7.53e-05 | 6.48e-04 | 44 |
GO:005109016 | Thyroid | PTC | regulation of DNA-binding transcription factor activity | 178/5968 | 440/18723 | 7.63e-05 | 6.54e-04 | 178 |
GO:00519608 | Thyroid | PTC | regulation of nervous system development | 177/5968 | 443/18723 | 1.72e-04 | 1.32e-03 | 177 |
GO:00603486 | Thyroid | PTC | bone development | 90/5968 | 205/18723 | 1.89e-04 | 1.42e-03 | 90 |
GO:00900925 | Thyroid | PTC | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 108/5968 | 256/18723 | 3.07e-04 | 2.14e-03 | 108 |
GO:001071812 | Thyroid | PTC | positive regulation of epithelial to mesenchymal transition | 29/5968 | 52/18723 | 3.09e-04 | 2.15e-03 | 29 |
GO:00301986 | Thyroid | PTC | extracellular matrix organization | 124/5968 | 301/18723 | 3.75e-04 | 2.53e-03 | 124 |
GO:00032055 | Thyroid | PTC | cardiac chamber development | 72/5968 | 161/18723 | 4.13e-04 | 2.77e-03 | 72 |
GO:00430626 | Thyroid | PTC | extracellular structure organization | 124/5968 | 302/18723 | 4.38e-04 | 2.92e-03 | 124 |
GO:190152213 | Thyroid | PTC | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | 15/5968 | 22/18723 | 5.11e-04 | 3.32e-03 | 15 |
GO:00452296 | Thyroid | PTC | external encapsulating structure organization | 124/5968 | 304/18723 | 5.96e-04 | 3.79e-03 | 124 |
GO:004876215 | Thyroid | PTC | mesenchymal cell differentiation | 99/5968 | 236/18723 | 6.72e-04 | 4.22e-03 | 99 |
GO:003017810 | Thyroid | PTC | negative regulation of Wnt signaling pathway | 74/5968 | 170/18723 | 8.99e-04 | 5.48e-03 | 74 |
GO:007190112 | Thyroid | PTC | negative regulation of protein serine/threonine kinase activity | 55/5968 | 120/18723 | 9.30e-04 | 5.65e-03 | 55 |
GO:005109115 | Thyroid | PTC | positive regulation of DNA-binding transcription factor activity | 107/5968 | 260/18723 | 9.44e-04 | 5.70e-03 | 107 |
GO:19030554 | Thyroid | PTC | positive regulation of extracellular matrix organization | 16/5968 | 25/18723 | 9.53e-04 | 5.72e-03 | 16 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043909 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa043504 | Endometrium | AEH | TGF-beta signaling pathway | 26/1197 | 108/8465 | 3.82e-03 | 2.18e-02 | 1.59e-02 | 26 |
hsa0439014 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0435011 | Endometrium | AEH | TGF-beta signaling pathway | 26/1197 | 108/8465 | 3.82e-03 | 2.18e-02 | 1.59e-02 | 26 |
hsa0439023 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa043502 | Endometrium | EEC | TGF-beta signaling pathway | 26/1237 | 108/8465 | 5.95e-03 | 3.12e-02 | 2.33e-02 | 26 |
hsa0439033 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa043503 | Endometrium | EEC | TGF-beta signaling pathway | 26/1237 | 108/8465 | 5.95e-03 | 3.12e-02 | 2.33e-02 | 26 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa043906 | Stomach | CAG with IM | Hippo signaling pathway | 21/640 | 157/8465 | 7.26e-03 | 4.05e-02 | 2.84e-02 | 21 |
hsa0439011 | Stomach | CAG with IM | Hippo signaling pathway | 21/640 | 157/8465 | 7.26e-03 | 4.05e-02 | 2.84e-02 | 21 |
hsa0439021 | Stomach | CSG | Hippo signaling pathway | 21/633 | 157/8465 | 6.42e-03 | 3.62e-02 | 2.61e-02 | 21 |
hsa0439031 | Stomach | CSG | Hippo signaling pathway | 21/633 | 157/8465 | 6.42e-03 | 3.62e-02 | 2.61e-02 | 21 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | AD |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | ADJ |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | ADJ |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | FAP |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | FAP |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | CRC | Healthy |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | CRC | Healthy |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | Endometrium | AEH |
BMP2 | BMPR1B_BMPR2 | BMP2_BMPR1B_BMPR2 | BMP | Endometrium | AEH |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | Endometrium | EEC |
BMP2 | BMPR1A_ACVR2B | BMP2_BMPR1A_ACVR2B | BMP | Esophagus | ESCC |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | HNSCC | Precancer |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | Lung | AAH |
BMP2 | BMPR1B_BMPR2 | BMP2_BMPR1B_BMPR2 | BMP | Lung | AAH |
BMP2 | BMPR1A_ACVR2A | BMP2_BMPR1A_ACVR2A | BMP | THCA | ADJ |
BMP2 | BMPR1A_BMPR2 | BMP2_BMPR1A_BMPR2 | BMP | THCA | ADJ |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMP2 | SNV | Missense_Mutation | rs759121274 | c.871N>T | p.Arg291Cys | p.R291C | P12643 | protein_coding | deleterious(0) | possibly_damaging(0.523) | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BMP2 | SNV | Missense_Mutation | novel | c.1099N>T | p.Ser367Cys | p.S367C | P12643 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
BMP2 | insertion | Frame_Shift_Ins | novel | c.1174_1175insAACTTACAGAACAGAGAGAAGGGAGGCTCCATGTTTATTTAAA | p.Gly392GlufsTer25 | p.G392Efs*25 | P12643 | protein_coding | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | ||
BMP2 | insertion | In_Frame_Ins | novel | c.1101_1102insGTCCACTTAGCTTGCATGATGACTGTTGCTTTGATGATGAAG | p.Ser367_Ala368insValHisLeuAlaCysMetMetThrValAlaLeuMetMetLys | p.S367_A368insVHLACMMTVALMMK | P12643 | protein_coding | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
BMP2 | insertion | Frame_Shift_Ins | novel | c.874_875insACGATGAGGT | p.Leu292HisfsTer5 | p.L292Hfs*5 | P12643 | protein_coding | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
BMP2 | SNV | Missense_Mutation | rs763897233 | c.73N>A | p.Val25Ile | p.V25I | P12643 | protein_coding | tolerated(1) | benign(0) | TCGA-VS-A957-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMP2 | SNV | Missense_Mutation | novel | c.113N>G | p.Ser38Trp | p.S38W | P12643 | protein_coding | deleterious(0.01) | benign(0.084) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMP2 | SNV | Missense_Mutation | novel | c.142G>A | p.Glu48Lys | p.E48K | P12643 | protein_coding | tolerated(0.21) | benign(0.009) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
BMP2 | SNV | Missense_Mutation | rs756645581 | c.292C>T | p.Arg98Trp | p.R98W | P12643 | protein_coding | tolerated(0.17) | possibly_damaging(0.571) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
BMP2 | SNV | Missense_Mutation | rs190569855 | c.979N>A | p.Gly327Arg | p.G327R | P12643 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | BUTAMBEN | BUTAMBEN | 22041064 | |
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | METHYL 4-AMINOBENZOATE | CHEMBL1927048 | 22041064 | |
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | DWP-431 | |||
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | BUTYL 4-ACETAMIDOBENZOATE | CHEMBL1321401 | 22041064 | |
650 | BMP2 | CELL SURFACE, GROWTH FACTOR, DRUGGABLE GENOME, TRANSCRIPTION FACTOR | ISOPROPYL 4-AMINOBENZOATE | CHEMBL1467165 | 22041064 |
Page: 1 |