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Gene: ARPC2 |
Gene summary for ARPC2 |
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Gene information | Species | Human | Gene symbol | ARPC2 | Gene ID | 10109 |
Gene name | actin related protein 2/3 complex subunit 2 | |
Gene Alias | ARC34 | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O15144 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10109 | ARPC2 | GSM4909282 | Human | Breast | IDC | 4.95e-04 | 3.04e-01 | -0.0288 |
10109 | ARPC2 | GSM4909285 | Human | Breast | IDC | 9.28e-08 | 4.50e-01 | 0.21 |
10109 | ARPC2 | GSM4909286 | Human | Breast | IDC | 8.16e-03 | -1.50e-01 | 0.1081 |
10109 | ARPC2 | GSM4909288 | Human | Breast | IDC | 1.91e-04 | 2.33e-01 | 0.0988 |
10109 | ARPC2 | GSM4909294 | Human | Breast | IDC | 2.63e-07 | -8.71e-02 | 0.2022 |
10109 | ARPC2 | GSM4909296 | Human | Breast | IDC | 8.23e-17 | 3.63e-02 | 0.1524 |
10109 | ARPC2 | GSM4909297 | Human | Breast | IDC | 2.97e-24 | -1.60e-01 | 0.1517 |
10109 | ARPC2 | GSM4909311 | Human | Breast | IDC | 7.72e-49 | -5.04e-01 | 0.1534 |
10109 | ARPC2 | GSM4909312 | Human | Breast | IDC | 2.44e-16 | 4.21e-02 | 0.1552 |
10109 | ARPC2 | GSM4909315 | Human | Breast | IDC | 9.50e-24 | 5.09e-01 | 0.21 |
10109 | ARPC2 | GSM4909316 | Human | Breast | IDC | 1.55e-17 | 5.56e-01 | 0.21 |
10109 | ARPC2 | GSM4909319 | Human | Breast | IDC | 5.28e-62 | -2.72e-01 | 0.1563 |
10109 | ARPC2 | GSM4909320 | Human | Breast | IDC | 3.00e-07 | -3.54e-01 | 0.1575 |
10109 | ARPC2 | GSM4909321 | Human | Breast | IDC | 1.78e-19 | -2.05e-01 | 0.1559 |
10109 | ARPC2 | brca1 | Human | Breast | Precancer | 3.32e-28 | 6.35e-01 | -0.0338 |
10109 | ARPC2 | brca2 | Human | Breast | Precancer | 5.93e-04 | 3.11e-01 | -0.024 |
10109 | ARPC2 | brca3 | Human | Breast | Precancer | 7.10e-07 | 3.84e-01 | -0.0263 |
10109 | ARPC2 | brca10 | Human | Breast | Precancer | 1.95e-05 | 3.33e-01 | -0.0029 |
10109 | ARPC2 | M2 | Human | Breast | IDC | 2.35e-12 | 4.81e-01 | 0.21 |
10109 | ARPC2 | NCCBC11 | Human | Breast | DCIS | 4.27e-03 | -1.21e-02 | 0.1232 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1902905113 | Thyroid | PTC | positive regulation of supramolecular fiber organization | 114/5968 | 209/18723 | 8.48e-12 | 3.57e-10 | 114 |
GO:005149526 | Thyroid | PTC | positive regulation of cytoskeleton organization | 121/5968 | 226/18723 | 1.04e-11 | 4.27e-10 | 121 |
GO:0031346110 | Thyroid | PTC | positive regulation of cell projection organization | 173/5968 | 353/18723 | 1.09e-11 | 4.40e-10 | 173 |
GO:000815426 | Thyroid | PTC | actin polymerization or depolymerization | 117/5968 | 218/18723 | 1.85e-11 | 7.21e-10 | 117 |
GO:0032271113 | Thyroid | PTC | regulation of protein polymerization | 123/5968 | 233/18723 | 2.45e-11 | 9.38e-10 | 123 |
GO:0032535112 | Thyroid | PTC | regulation of cellular component size | 181/5968 | 383/18723 | 1.70e-10 | 5.64e-09 | 181 |
GO:0031334113 | Thyroid | PTC | positive regulation of protein-containing complex assembly | 121/5968 | 237/18723 | 5.70e-10 | 1.81e-08 | 121 |
GO:0010810112 | Thyroid | PTC | regulation of cell-substrate adhesion | 113/5968 | 221/18723 | 1.87e-09 | 5.28e-08 | 113 |
GO:0031589111 | Thyroid | PTC | cell-substrate adhesion | 169/5968 | 363/18723 | 2.73e-09 | 7.57e-08 | 169 |
GO:000806423 | Thyroid | PTC | regulation of actin polymerization or depolymerization | 98/5968 | 188/18723 | 6.00e-09 | 1.53e-07 | 98 |
GO:003004125 | Thyroid | PTC | actin filament polymerization | 99/5968 | 191/18723 | 7.40e-09 | 1.85e-07 | 99 |
GO:003083220 | Thyroid | PTC | regulation of actin filament length | 98/5968 | 189/18723 | 8.58e-09 | 2.10e-07 | 98 |
GO:0010769111 | Thyroid | PTC | regulation of cell morphogenesis involved in differentiation | 57/5968 | 96/18723 | 2.50e-08 | 5.62e-07 | 57 |
GO:003227327 | Thyroid | PTC | positive regulation of protein polymerization | 75/5968 | 138/18723 | 3.65e-08 | 8.02e-07 | 75 |
GO:003083326 | Thyroid | PTC | regulation of actin filament polymerization | 88/5968 | 172/18723 | 1.07e-07 | 2.11e-06 | 88 |
GO:001072018 | Thyroid | PTC | positive regulation of cell development | 138/5968 | 298/18723 | 1.13e-07 | 2.22e-06 | 138 |
GO:0010770111 | Thyroid | PTC | positive regulation of cell morphogenesis involved in differentiation | 48/5968 | 79/18723 | 1.15e-07 | 2.26e-06 | 48 |
GO:0120032111 | Thyroid | PTC | regulation of plasma membrane bounded cell projection assembly | 92/5968 | 186/18723 | 4.12e-07 | 6.83e-06 | 92 |
GO:006049120 | Thyroid | PTC | regulation of cell projection assembly | 92/5968 | 188/18723 | 7.55e-07 | 1.18e-05 | 92 |
GO:0010811112 | Thyroid | PTC | positive regulation of cell-substrate adhesion | 65/5968 | 123/18723 | 1.10e-06 | 1.62e-05 | 65 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513018 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453018 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510018 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0513019 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0453019 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0510019 | Breast | Precancer | Bacterial invasion of epithelial cells | 16/684 | 77/8465 | 3.55e-04 | 2.80e-03 | 2.15e-03 | 16 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453024 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513024 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0510024 | Breast | IDC | Bacterial invasion of epithelial cells | 17/867 | 77/8465 | 1.69e-03 | 1.19e-02 | 8.93e-03 | 17 |
hsa0481014 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0453034 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513034 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513134 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARPC2 | SNV | Missense_Mutation | c.442N>A | p.Asp148Asn | p.D148N | O15144 | protein_coding | tolerated(0.08) | benign(0.01) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ARPC2 | SNV | Missense_Mutation | c.836N>A | p.Arg279His | p.R279H | O15144 | protein_coding | deleterious(0.01) | possibly_damaging(0.808) | TCGA-D8-A145-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
ARPC2 | SNV | Missense_Mutation | c.57N>G | p.Phe19Leu | p.F19L | O15144 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-C5-A7CL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
ARPC2 | SNV | Missense_Mutation | c.130N>T | p.His44Tyr | p.H44Y | O15144 | protein_coding | deleterious(0) | benign(0.33) | TCGA-MU-A5YI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ARPC2 | SNV | Missense_Mutation | c.137N>T | p.Ser46Leu | p.S46L | O15144 | protein_coding | deleterious(0) | benign(0.134) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ARPC2 | SNV | Missense_Mutation | c.836N>A | p.Arg279His | p.R279H | O15144 | protein_coding | deleterious(0.01) | possibly_damaging(0.808) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARPC2 | SNV | Missense_Mutation | c.304N>A | p.Leu102Ile | p.L102I | O15144 | protein_coding | tolerated(0.27) | benign(0.013) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
ARPC2 | SNV | Missense_Mutation | c.186N>C | p.Lys62Asn | p.K62N | O15144 | protein_coding | tolerated(0.05) | benign(0.421) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
ARPC2 | SNV | Missense_Mutation | c.679N>A | p.Leu227Met | p.L227M | O15144 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARPC2 | SNV | Missense_Mutation | c.434N>G | p.His145Arg | p.H145R | O15144 | protein_coding | tolerated(0.08) | benign(0.015) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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