Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/STK3_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/STK3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/STK3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/STK3_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/STK3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/STK3_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/STK3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/STK3_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/STK3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/STK3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/STK3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/STK3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00486385 | Lung | IAC | regulation of developmental growth | 59/2061 | 330/18723 | 1.17e-04 | 2.22e-03 | 59 |
GO:00447733 | Lung | IAC | mitotic DNA damage checkpoint | 21/2061 | 81/18723 | 1.34e-04 | 2.50e-03 | 21 |
GO:00459301 | Lung | IAC | negative regulation of mitotic cell cycle | 45/2061 | 235/18723 | 1.49e-04 | 2.73e-03 | 45 |
GO:19019881 | Lung | IAC | negative regulation of cell cycle phase transition | 47/2061 | 249/18723 | 1.53e-04 | 2.80e-03 | 47 |
GO:00109481 | Lung | IAC | negative regulation of cell cycle process | 53/2061 | 294/18723 | 2.05e-04 | 3.58e-03 | 53 |
GO:00712146 | Lung | IAC | cellular response to abiotic stimulus | 58/2061 | 331/18723 | 2.30e-04 | 3.96e-03 | 58 |
GO:01040046 | Lung | IAC | cellular response to environmental stimulus | 58/2061 | 331/18723 | 2.30e-04 | 3.96e-03 | 58 |
GO:00018416 | Lung | IAC | neural tube formation | 24/2061 | 102/18723 | 2.35e-04 | 4.04e-03 | 24 |
GO:00020287 | Lung | IAC | regulation of sodium ion transport | 22/2061 | 90/18723 | 2.37e-04 | 4.05e-03 | 22 |
GO:00434103 | Lung | IAC | positive regulation of MAPK cascade | 78/2061 | 480/18723 | 2.72e-04 | 4.50e-03 | 78 |
GO:00447743 | Lung | IAC | mitotic DNA integrity checkpoint | 21/2061 | 85/18723 | 2.78e-04 | 4.56e-03 | 21 |
GO:00315703 | Lung | IAC | DNA integrity checkpoint | 27/2061 | 123/18723 | 3.34e-04 | 5.24e-03 | 27 |
GO:20012384 | Lung | IAC | positive regulation of extrinsic apoptotic signaling pathway | 14/2061 | 48/18723 | 4.72e-04 | 6.92e-03 | 14 |
GO:20012355 | Lung | IAC | positive regulation of apoptotic signaling pathway | 27/2061 | 126/18723 | 5.01e-04 | 7.25e-03 | 27 |
GO:00510998 | Lung | IAC | positive regulation of binding | 34/2061 | 173/18723 | 5.58e-04 | 7.76e-03 | 34 |
GO:00456002 | Lung | IAC | positive regulation of fat cell differentiation | 17/2061 | 66/18723 | 6.14e-04 | 8.46e-03 | 17 |
GO:00454443 | Lung | IAC | fat cell differentiation | 42/2061 | 229/18723 | 6.19e-04 | 8.50e-03 | 42 |
GO:00433938 | Lung | IAC | regulation of protein binding | 37/2061 | 196/18723 | 7.28e-04 | 9.60e-03 | 37 |
GO:00000752 | Lung | IAC | cell cycle checkpoint | 33/2061 | 169/18723 | 7.51e-04 | 9.82e-03 | 33 |
GO:00320926 | Lung | IAC | positive regulation of protein binding | 20/2061 | 85/18723 | 7.54e-04 | 9.82e-03 | 20 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK3 | SNV | Missense_Mutation | | c.533N>T | p.Gly178Val | p.G178V | Q13188 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | rs545643657 | c.1306N>A | p.Glu436Lys | p.E436K | Q13188 | protein_coding | tolerated(0.62) | benign(0.007) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | novel | c.1419N>T | p.Leu473Phe | p.L473F | Q13188 | protein_coding | tolerated(0.63) | benign(0.013) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
STK3 | insertion | Nonsense_Mutation | novel | c.775_776insAGAAATCAG | p.Phe259delinsTer | p.F259delins* | Q13188 | protein_coding | | | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
STK3 | insertion | Frame_Shift_Ins | novel | c.1417_1418insCC | p.Leu473SerfsTer2 | p.L473Sfs*2 | Q13188 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
STK3 | insertion | Frame_Shift_Ins | novel | c.719_720insCCTCAGACCAAAGAAG | p.Glu241LeufsTer9 | p.E241Lfs*9 | Q13188 | protein_coding | | | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | | c.244N>A | p.Ala82Thr | p.A82T | Q13188 | protein_coding | deleterious(0.02) | probably_damaging(0.981) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
STK3 | SNV | Missense_Mutation | novel | c.541N>T | p.Leu181Phe | p.L181F | Q13188 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EA-A3Y4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | | c.721N>C | p.Glu241Gln | p.E241Q | Q13188 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
STK3 | SNV | Missense_Mutation | | c.425N>A | p.Arg142Gln | p.R142Q | Q13188 | protein_coding | tolerated(0.06) | possibly_damaging(0.723) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | SOTRASTAURIN | SOTRASTAURIN | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | ALSTERPAULLONE | ALSTERPAULLONE | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | SP-600125 | SP-600125 | 23634759 |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | inhibitor | 249565869 | CEP-11981 | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | BAY-613606 | CHEMBL541400 | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | TAE-684 | TAE-684 | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | LAUROGUADINE | LAUROGUADINE | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | PF-562271 | PF-00562271 | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | GW441756X | GW441756X | |
6788 | STK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ENZYME | | ILORASERTIB | ILORASERTIB | |