Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PHB2

Gene summary for PHB2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PHB2

Gene ID

11331

Gene nameprohibitin 2
Gene AliasBAP
Cytomap12p13.31
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q99623


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11331PHB2HTA11_3410_2000001011HumanColorectumAD1.13e-083.65e-010.0155
11331PHB2HTA11_2487_2000001011HumanColorectumSER1.54e-116.33e-01-0.1808
11331PHB2HTA11_2951_2000001011HumanColorectumAD4.61e-036.33e-010.0216
11331PHB2HTA11_1938_2000001011HumanColorectumAD6.28e-115.66e-01-0.0811
11331PHB2HTA11_78_2000001011HumanColorectumAD1.15e-187.79e-01-0.1088
11331PHB2HTA11_347_2000001011HumanColorectumAD1.10e-431.03e+00-0.1954
11331PHB2HTA11_411_2000001011HumanColorectumSER2.09e-026.63e-01-0.2602
11331PHB2HTA11_3361_2000001011HumanColorectumAD8.53e-137.69e-01-0.1207
11331PHB2HTA11_83_2000001011HumanColorectumSER2.79e-075.12e-01-0.1526
11331PHB2HTA11_696_2000001011HumanColorectumAD6.95e-286.35e-01-0.1464
11331PHB2HTA11_866_2000001011HumanColorectumAD2.30e-206.06e-01-0.1001
11331PHB2HTA11_1391_2000001011HumanColorectumAD7.68e-247.81e-01-0.059
11331PHB2HTA11_2992_2000001011HumanColorectumSER8.93e-056.13e-01-0.1706
11331PHB2HTA11_5212_2000001011HumanColorectumAD3.56e-064.49e-01-0.2061
11331PHB2HTA11_5216_2000001011HumanColorectumSER2.64e-026.12e-01-0.1462
11331PHB2HTA11_546_2000001011HumanColorectumAD1.19e-107.77e-01-0.0842
11331PHB2HTA11_9341_2000001011HumanColorectumSER4.88e-035.17e-01-0.00410000000000005
11331PHB2HTA11_866_3004761011HumanColorectumAD1.11e-246.81e-010.096
11331PHB2HTA11_4255_2000001011HumanColorectumSER5.98e-118.28e-010.0446
11331PHB2HTA11_8622_2000001021HumanColorectumSER6.56e-076.04e-010.0528
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00704827LiverCirrhoticresponse to oxygen levels125/4634347/187231.55e-063.02e-05125
GO:001921611LiverCirrhoticregulation of lipid metabolic process119/4634331/187233.05e-065.39e-05119
GO:004340111LiverCirrhoticsteroid hormone mediated signaling pathway58/4634136/187233.44e-065.95e-0558
GO:00073463LiverCirrhoticregulation of mitotic cell cycle154/4634457/187238.73e-061.29e-04154
GO:003051811LiverCirrhoticintracellular steroid hormone receptor signaling pathway50/4634116/187231.11e-051.59e-0450
GO:00362937LiverCirrhoticresponse to decreased oxygen levels113/4634322/187231.87e-052.52e-04113
GO:00096155LiverCirrhoticresponse to virus126/4634367/187232.10e-052.77e-04126
GO:00016667LiverCirrhoticresponse to hypoxia108/4634307/187232.51e-053.26e-04108
GO:19012241LiverCirrhoticpositive regulation of NIK/NF-kappaB signaling33/463469/187232.70e-053.46e-0433
GO:00170387LiverCirrhoticprotein import77/4634206/187233.56e-054.32e-0477
GO:001050811LiverCirrhoticpositive regulation of autophagy51/4634124/187234.25e-055.03e-0451
GO:000975511LiverCirrhotichormone-mediated signaling pathway71/4634190/187237.09e-057.98e-0471
GO:00714536LiverCirrhoticcellular response to oxygen levels67/4634177/187237.10e-057.98e-0467
GO:00459313LiverCirrhoticpositive regulation of mitotic cell cycle49/4634121/187239.47e-051.01e-0349
GO:00447721LiverCirrhoticmitotic cell cycle phase transition139/4634424/187231.02e-041.06e-03139
GO:1901222LiverCirrhoticregulation of NIK/NF-kappaB signaling46/4634112/187231.03e-041.06e-0346
GO:00190482LiverCirrhoticmodulation by virus of host process9/463411/187231.15e-041.15e-039
GO:01400142LiverCirrhoticmitotic nuclear division97/4634287/187233.32e-042.87e-0397
GO:0038061LiverCirrhoticNIK/NF-kappaB signaling54/4634143/187233.64e-043.07e-0354
GO:00619124LiverCirrhoticselective autophagy30/463468/187233.72e-043.12e-0330
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
EFNA5EPHB2EFNA5_EPHB2EPHACervixCC
EFNB1EPHB2EFNB1_EPHB2EPHBCervixCC
EFNB2EPHB2EFNB2_EPHB2EPHBCervixCC
EFNB1EPHB2EFNB1_EPHB2EPHBCRCAD
EFNB2EPHB2EFNB2_EPHB2EPHBCRCAD
EFNA5EPHB2EFNA5_EPHB2EPHACRCAD
EFNA5EPHB2EFNA5_EPHB2EPHACRCADJ
EFNB1EPHB2EFNB1_EPHB2EPHBCRCADJ
EFNB2EPHB2EFNB2_EPHB2EPHBCRCADJ
EFNA5EPHB2EFNA5_EPHB2EPHACRCCRC
EFNB2EPHB2EFNB2_EPHB2EPHBCRCCRC
EFNA5EPHB2EFNA5_EPHB2EPHACRCFAP
EFNB2EPHB2EFNB2_EPHB2EPHBCRCFAP
EFNA5EPHB2EFNA5_EPHB2EPHACRCHealthy
EFNB2EPHB2EFNB2_EPHB2EPHBCRCHealthy
EFNA5EPHB2EFNA5_EPHB2EPHACRCMSI-H
EFNB1EPHB2EFNB1_EPHB2EPHBCRCMSI-H
EFNB2EPHB2EFNB2_EPHB2EPHBCRCMSI-H
EFNB1EPHB2EFNB1_EPHB2EPHBCRCMSS
EFNB2EPHB2EFNB2_EPHB2EPHBCRCMSS
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PHB2SNVMissense_Mutationc.896A>Cp.Lys299Thrp.K299TQ99623protein_codingdeleterious_low_confidence(0)benign(0.143)TCGA-EW-A1PE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilSD
PHB2insertionFrame_Shift_Insnovelc.377_378insATTGGGAATTAp.Asp127LeufsTer31p.D127Lfs*31Q99623protein_codingTCGA-A8-A08T-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
PHB2SNVMissense_Mutationc.415N>Cp.Glu139Glnp.E139QQ99623protein_codingdeleterious(0)probably_damaging(1)TCGA-IR-A3LA-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
PHB2insertionFrame_Shift_Insnovelc.44_45insCCCATp.Arg17CysfsTer9p.R17Cfs*9Q99623protein_codingTCGA-A6-6653-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
PHB2insertionFrame_Shift_Insnovelc.43_44insTp.Gly15ValfsTer68p.G15Vfs*68Q99623protein_codingTCGA-A6-6653-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
PHB2SNVMissense_Mutationrs782150944c.368G>Ap.Arg123Hisp.R123HQ99623protein_codingtolerated(0.14)benign(0.013)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
PHB2SNVMissense_Mutationc.283N>Tp.Gly95Cysp.G95CQ99623protein_codingdeleterious(0)probably_damaging(0.995)TCGA-AP-A051-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
PHB2SNVMissense_Mutationnovelc.754C>Tp.Arg252Cysp.R252CQ99623protein_codingdeleterious(0)probably_damaging(1)TCGA-AX-A2HC-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapypaclitaxelPD
PHB2SNVMissense_Mutationnovelc.895A>Cp.Lys299Glnp.K299QQ99623protein_codingdeleterious_low_confidence(0.01)benign(0.146)TCGA-AX-A2IO-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIChemotherapycarboplatinSD
PHB2SNVMissense_Mutationc.196N>Cp.Glu66Glnp.E66QQ99623protein_codingdeleterious(0.02)probably_damaging(0.992)TCGA-B5-A11R-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapypaclitaxelSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
11331PHB2CELL SURFACESTEROID HORMONE10850416
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