Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/C1QBP_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/C1QBP_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/C1QBP_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/C1QBP_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/C1QBP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/C1QBP_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/C1QBP_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/C1QBP_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/C1QBP_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/C1QBP_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/C1QBP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00026831 | Stomach | CAG with IM | negative regulation of immune system process | 43/1050 | 434/18723 | 2.14e-04 | 3.94e-03 | 43 |
GO:00160641 | Stomach | CAG with IM | immunoglobulin mediated immune response | 25/1050 | 207/18723 | 2.50e-04 | 4.46e-03 | 25 |
GO:00197241 | Stomach | CAG with IM | B cell mediated immunity | 25/1050 | 210/18723 | 3.12e-04 | 5.27e-03 | 25 |
GO:003311911 | Stomach | CAG with IM | negative regulation of RNA splicing | 7/1050 | 25/18723 | 3.37e-04 | 5.49e-03 | 7 |
GO:190002611 | Stomach | CAG with IM | positive regulation of substrate adhesion-dependent cell spreading | 9/1050 | 41/18723 | 3.65e-04 | 5.89e-03 | 9 |
GO:00716241 | Stomach | CAG with IM | positive regulation of granulocyte chemotaxis | 7/1050 | 27/18723 | 5.64e-04 | 8.28e-03 | 7 |
GO:00975301 | Stomach | CAG with IM | granulocyte migration | 19/1050 | 148/18723 | 6.27e-04 | 8.92e-03 | 19 |
GO:00975291 | Stomach | CAG with IM | myeloid leukocyte migration | 25/1050 | 220/18723 | 6.28e-04 | 8.92e-03 | 25 |
GO:19026241 | Stomach | CAG with IM | positive regulation of neutrophil migration | 7/1050 | 28/18723 | 7.16e-04 | 9.88e-03 | 7 |
GO:00096151 | Stomach | CAG with IM | response to virus | 36/1050 | 367/18723 | 8.12e-04 | 1.08e-02 | 36 |
GO:001076911 | Stomach | CAG with IM | regulation of cell morphogenesis involved in differentiation | 14/1050 | 96/18723 | 9.03e-04 | 1.17e-02 | 14 |
GO:003052211 | Stomach | CAG with IM | intracellular receptor signaling pathway | 28/1050 | 265/18723 | 9.76e-04 | 1.26e-02 | 28 |
GO:00027641 | Stomach | CAG with IM | immune response-regulating signaling pathway | 43/1050 | 468/18723 | 1.03e-03 | 1.29e-02 | 43 |
GO:000641711 | Stomach | CAG with IM | regulation of translation | 43/1050 | 468/18723 | 1.03e-03 | 1.29e-02 | 43 |
GO:003158911 | Stomach | CAG with IM | cell-substrate adhesion | 35/1050 | 363/18723 | 1.29e-03 | 1.53e-02 | 35 |
GO:00026881 | Stomach | CAG with IM | regulation of leukocyte chemotaxis | 16/1050 | 122/18723 | 1.30e-03 | 1.54e-02 | 16 |
GO:00603261 | Stomach | CAG with IM | cell chemotaxis | 31/1050 | 310/18723 | 1.33e-03 | 1.57e-02 | 31 |
GO:001081011 | Stomach | CAG with IM | regulation of cell-substrate adhesion | 24/1050 | 221/18723 | 1.50e-03 | 1.69e-02 | 24 |
GO:00716741 | Stomach | CAG with IM | mononuclear cell migration | 22/1050 | 196/18723 | 1.52e-03 | 1.70e-02 | 22 |
GO:004348411 | Stomach | CAG with IM | regulation of RNA splicing | 18/1050 | 148/18723 | 1.61e-03 | 1.78e-02 | 18 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1QBP | SNV | Missense_Mutation | novel | c.529N>C | p.Asp177His | p.D177H | Q07021 | protein_coding | tolerated(0.13) | possibly_damaging(0.807) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
C1QBP | SNV | Missense_Mutation | | c.352N>A | p.Ala118Thr | p.A118T | Q07021 | protein_coding | deleterious(0.04) | possibly_damaging(0.601) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | novel | c.304N>A | p.Leu102Ile | p.L102I | Q07021 | protein_coding | tolerated(0.22) | possibly_damaging(0.562) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | novel | c.814N>A | p.Leu272Ile | p.L272I | Q07021 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | | c.245N>C | p.Phe82Ser | p.F82S | Q07021 | protein_coding | deleterious(0) | possibly_damaging(0.764) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | rs115819590 | c.643N>A | p.Gly215Ser | p.G215S | Q07021 | protein_coding | tolerated_low_confidence(0.09) | benign(0.107) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | novel | c.751A>G | p.Thr251Ala | p.T251A | Q07021 | protein_coding | tolerated(0.1) | possibly_damaging(0.559) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
C1QBP | SNV | Missense_Mutation | novel | c.677N>C | p.Leu226Pro | p.L226P | Q07021 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | novel | c.296N>G | p.His99Arg | p.H99R | Q07021 | protein_coding | tolerated(0.38) | benign(0.055) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C1QBP | SNV | Missense_Mutation | | c.481N>A | p.Glu161Lys | p.E161K | Q07021 | protein_coding | deleterious(0.02) | possibly_damaging(0.684) | TCGA-18-5595-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |