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Gene: SPR |
Gene summary for SPR |
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Gene information | Species | Human | Gene symbol | SPR | Gene ID | 6697 |
Gene name | sepiapterin reductase | |
Gene Alias | SDR38C1 | |
Cytomap | 2p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | P35270 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6697 | SPR | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.11e-08 | 2.38e-01 | 0.0155 |
6697 | SPR | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.92e-14 | 4.48e-01 | -0.1808 |
6697 | SPR | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.79e-12 | 4.81e-01 | -0.0811 |
6697 | SPR | HTA11_78_2000001011 | Human | Colorectum | AD | 1.17e-02 | 2.62e-01 | -0.1088 |
6697 | SPR | HTA11_347_2000001011 | Human | Colorectum | AD | 1.36e-25 | 5.76e-01 | -0.1954 |
6697 | SPR | HTA11_411_2000001011 | Human | Colorectum | SER | 3.05e-06 | 6.82e-01 | -0.2602 |
6697 | SPR | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.64e-02 | 4.98e-01 | -0.2196 |
6697 | SPR | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.20e-08 | 3.63e-01 | -0.1207 |
6697 | SPR | HTA11_83_2000001011 | Human | Colorectum | SER | 1.41e-10 | 4.74e-01 | -0.1526 |
6697 | SPR | HTA11_696_2000001011 | Human | Colorectum | AD | 1.38e-18 | 4.38e-01 | -0.1464 |
6697 | SPR | HTA11_866_2000001011 | Human | Colorectum | AD | 1.14e-07 | 2.54e-01 | -0.1001 |
6697 | SPR | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.26e-15 | 4.78e-01 | -0.059 |
6697 | SPR | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.78e-08 | 4.70e-01 | -0.1706 |
6697 | SPR | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.30e-10 | 5.49e-01 | -0.2061 |
6697 | SPR | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.30e-07 | 6.16e-01 | -0.1462 |
6697 | SPR | HTA11_546_2000001011 | Human | Colorectum | AD | 1.94e-02 | 2.83e-01 | -0.0842 |
6697 | SPR | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.64e-06 | 3.85e-01 | -0.0179 |
6697 | SPR | HTA11_866_3004761011 | Human | Colorectum | AD | 1.23e-11 | 3.94e-01 | 0.096 |
6697 | SPR | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.10e-02 | 3.00e-01 | 0.0446 |
6697 | SPR | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.18e-08 | 4.57e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200102025 | Thyroid | HT | regulation of response to DNA damage stimulus | 27/1272 | 219/18723 | 1.95e-03 | 1.73e-02 | 27 |
GO:19038449 | Thyroid | HT | regulation of cellular response to transforming growth factor beta stimulus | 18/1272 | 131/18723 | 3.30e-03 | 2.59e-02 | 18 |
GO:00703726 | Thyroid | HT | regulation of ERK1 and ERK2 cascade | 34/1272 | 309/18723 | 3.77e-03 | 2.81e-02 | 34 |
GO:004354218 | Thyroid | HT | endothelial cell migration | 31/1272 | 279/18723 | 4.78e-03 | 3.29e-02 | 31 |
GO:00902874 | Thyroid | HT | regulation of cellular response to growth factor stimulus | 33/1272 | 304/18723 | 5.25e-03 | 3.50e-02 | 33 |
GO:00170158 | Thyroid | HT | regulation of transforming growth factor beta receptor signaling pathway | 17/1272 | 128/18723 | 5.97e-03 | 3.77e-02 | 17 |
GO:00105949 | Thyroid | HT | regulation of endothelial cell migration | 26/1272 | 232/18723 | 8.27e-03 | 4.78e-02 | 26 |
GO:00604858 | Thyroid | HT | mesenchyme development | 31/1272 | 291/18723 | 8.69e-03 | 4.92e-02 | 31 |
GO:0010563113 | Thyroid | PTC | negative regulation of phosphorus metabolic process | 219/5968 | 442/18723 | 4.47e-15 | 3.07e-13 | 219 |
GO:0045936113 | Thyroid | PTC | negative regulation of phosphate metabolic process | 218/5968 | 441/18723 | 7.08e-15 | 4.75e-13 | 218 |
GO:005165620 | Thyroid | PTC | establishment of organelle localization | 193/5968 | 390/18723 | 2.21e-13 | 1.15e-11 | 193 |
GO:0001933113 | Thyroid | PTC | negative regulation of protein phosphorylation | 173/5968 | 342/18723 | 3.46e-13 | 1.75e-11 | 173 |
GO:0042326113 | Thyroid | PTC | negative regulation of phosphorylation | 189/5968 | 385/18723 | 1.00e-12 | 4.64e-11 | 189 |
GO:0051348113 | Thyroid | PTC | negative regulation of transferase activity | 137/5968 | 268/18723 | 3.78e-11 | 1.36e-09 | 137 |
GO:0072331113 | Thyroid | PTC | signal transduction by p53 class mediator | 92/5968 | 163/18723 | 7.29e-11 | 2.54e-09 | 92 |
GO:007155919 | Thyroid | PTC | response to transforming growth factor beta | 131/5968 | 256/18723 | 9.20e-11 | 3.17e-09 | 131 |
GO:0007163111 | Thyroid | PTC | establishment or maintenance of cell polarity | 115/5968 | 218/18723 | 1.15e-10 | 3.90e-09 | 115 |
GO:000726519 | Thyroid | PTC | Ras protein signal transduction | 162/5968 | 337/18723 | 3.16e-10 | 1.02e-08 | 162 |
GO:007156019 | Thyroid | PTC | cellular response to transforming growth factor beta stimulus | 126/5968 | 250/18723 | 7.34e-10 | 2.19e-08 | 126 |
GO:2001020112 | Thyroid | PTC | regulation of response to DNA damage stimulus | 113/5968 | 219/18723 | 9.37e-10 | 2.77e-08 | 113 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0124021 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
hsa0124031 | Oral cavity | LP | Biosynthesis of cofactors | 57/2418 | 153/8465 | 1.17e-02 | 3.91e-02 | 2.52e-02 | 57 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
SPR | LUM | Prostate | ADJ | SERPINH1,LSAMP-AS1,ZFAND2A, etc. | 6.68e-01 | ![]() |
SPR | M2MAC | Skin | cSCC | LIPA,RCAN1,CHCHD10, etc. | 2.78e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPR | SNV | Missense_Mutation | c.561N>T | p.Glu187Asp | p.E187D | P35270 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPR | SNV | Missense_Mutation | c.392N>G | p.Met131Arg | p.M131R | P35270 | protein_coding | deleterious(0.03) | possibly_damaging(0.874) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPR | SNV | Missense_Mutation | c.535N>G | p.Met179Val | p.M179V | P35270 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SPR | SNV | Missense_Mutation | c.166N>A | p.Ala56Thr | p.A56T | P35270 | protein_coding | tolerated(0.19) | benign(0.041) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPR | SNV | Missense_Mutation | novel | c.406N>G | p.Ser136Ala | p.S136A | P35270 | protein_coding | tolerated(0.8) | benign(0.042) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPR | SNV | Missense_Mutation | novel | c.599C>A | p.Pro200His | p.P200H | P35270 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPR | SNV | Missense_Mutation | novel | c.479C>T | p.Ala160Val | p.A160V | P35270 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SPR | SNV | Missense_Mutation | novel | c.308N>A | p.Ser103Tyr | p.S103Y | P35270 | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPR | SNV | Missense_Mutation | rs767434287 | c.467N>T | p.Ser156Leu | p.S156L | P35270 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPR | SNV | Missense_Mutation | novel | c.529N>T | p.Arg177Cys | p.R177C | P35270 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EY-A1G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL1471 | APREPITANT | |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL105060 | DNK333 | |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL3544947 | BURAPITANT | |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL2104927 | FIGOPITANT | |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL2104992 | VESTIPITANT MESYLATE | |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL1201782 | FOSAPREPITANT DIMEGLUMINE | |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL3544984 | TRADIPITANT | |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL522302 | VOFOPITANT | |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL2105667 | ORVEPITANT | |
6697 | SPR | DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE, ENZYME | antagonist | CHEMBL515966 | EZLOPITANT |
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