Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/C1QBP_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/C1QBP_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/C1QBP_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/C1QBP_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/C1QBP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/C1QBP_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/C1QBP_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/C1QBP_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/C1QBP_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/C1QBP_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/C1QBP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002253 | Stomach | GC | activation of immune response | 36/1159 | 375/18723 | 6.03e-03 | 4.55e-02 | 36 |
GO:0002449 | Stomach | GC | lymphocyte mediated immunity | 34/1159 | 350/18723 | 6.25e-03 | 4.69e-02 | 34 |
GO:0071677 | Stomach | GC | positive regulation of mononuclear cell migration | 10/1159 | 65/18723 | 6.34e-03 | 4.73e-02 | 10 |
GO:0006956 | Stomach | GC | complement activation | 16/1159 | 130/18723 | 6.54e-03 | 4.83e-02 | 16 |
GO:0006958 | Stomach | GC | complement activation, classical pathway | 14/1159 | 108/18723 | 6.75e-03 | 4.90e-02 | 14 |
GO:004225511 | Stomach | CAG with IM | ribosome assembly | 18/1050 | 61/18723 | 3.44e-09 | 3.53e-07 | 18 |
GO:002260411 | Stomach | CAG with IM | regulation of cell morphogenesis | 41/1050 | 309/18723 | 2.63e-07 | 1.61e-05 | 41 |
GO:004578511 | Stomach | CAG with IM | positive regulation of cell adhesion | 49/1050 | 437/18723 | 3.01e-06 | 1.23e-04 | 49 |
GO:00069591 | Stomach | CAG with IM | humoral immune response | 39/1050 | 317/18723 | 3.43e-06 | 1.36e-04 | 39 |
GO:004572711 | Stomach | CAG with IM | positive regulation of translation | 22/1050 | 136/18723 | 6.73e-06 | 2.42e-04 | 22 |
GO:004225411 | Stomach | CAG with IM | ribosome biogenesis | 36/1050 | 299/18723 | 1.31e-05 | 4.29e-04 | 36 |
GO:002261311 | Stomach | CAG with IM | ribonucleoprotein complex biogenesis | 49/1050 | 463/18723 | 1.47e-05 | 4.77e-04 | 49 |
GO:003425011 | Stomach | CAG with IM | positive regulation of cellular amide metabolic process | 23/1050 | 162/18723 | 3.71e-05 | 1.02e-03 | 23 |
GO:00509001 | Stomach | CAG with IM | leukocyte migration | 40/1050 | 369/18723 | 5.16e-05 | 1.32e-03 | 40 |
GO:190002411 | Stomach | CAG with IM | regulation of substrate adhesion-dependent cell spreading | 12/1050 | 57/18723 | 6.16e-05 | 1.51e-03 | 12 |
GO:00305951 | Stomach | CAG with IM | leukocyte chemotaxis | 28/1050 | 230/18723 | 9.52e-05 | 2.16e-03 | 28 |
GO:003444611 | Stomach | CAG with IM | substrate adhesion-dependent cell spreading | 17/1050 | 108/18723 | 1.03e-04 | 2.28e-03 | 17 |
GO:00026851 | Stomach | CAG with IM | regulation of leukocyte migration | 26/1050 | 210/18723 | 1.27e-04 | 2.64e-03 | 26 |
GO:00026871 | Stomach | CAG with IM | positive regulation of leukocyte migration | 19/1050 | 135/18723 | 1.92e-04 | 3.62e-03 | 19 |
GO:00716211 | Stomach | CAG with IM | granulocyte chemotaxis | 18/1050 | 125/18723 | 2.10e-04 | 3.90e-03 | 18 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C1QBP | SNV | Missense_Mutation | novel | c.529N>C | p.Asp177His | p.D177H | Q07021 | protein_coding | tolerated(0.13) | possibly_damaging(0.807) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
C1QBP | SNV | Missense_Mutation | | c.352N>A | p.Ala118Thr | p.A118T | Q07021 | protein_coding | deleterious(0.04) | possibly_damaging(0.601) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | novel | c.304N>A | p.Leu102Ile | p.L102I | Q07021 | protein_coding | tolerated(0.22) | possibly_damaging(0.562) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | novel | c.814N>A | p.Leu272Ile | p.L272I | Q07021 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | | c.245N>C | p.Phe82Ser | p.F82S | Q07021 | protein_coding | deleterious(0) | possibly_damaging(0.764) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | rs115819590 | c.643N>A | p.Gly215Ser | p.G215S | Q07021 | protein_coding | tolerated_low_confidence(0.09) | benign(0.107) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | novel | c.751A>G | p.Thr251Ala | p.T251A | Q07021 | protein_coding | tolerated(0.1) | possibly_damaging(0.559) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
C1QBP | SNV | Missense_Mutation | novel | c.677N>C | p.Leu226Pro | p.L226P | Q07021 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C1QBP | SNV | Missense_Mutation | novel | c.296N>G | p.His99Arg | p.H99R | Q07021 | protein_coding | tolerated(0.38) | benign(0.055) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
C1QBP | SNV | Missense_Mutation | | c.481N>A | p.Glu161Lys | p.E161K | Q07021 | protein_coding | deleterious(0.02) | possibly_damaging(0.684) | TCGA-18-5595-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |