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Gene: ATP5F1E |
Gene summary for ATP5F1E |
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Gene information | Species | Human | Gene symbol | ATP5F1E | Gene ID | 514 |
Gene name | ATP synthase F1 subunit epsilon | |
Gene Alias | ATP5E | |
Cytomap | 20q13.32 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P56381 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
514 | ATP5F1E | GSM4909281 | Human | Breast | IDC | 2.59e-20 | 3.75e-01 | 0.21 |
514 | ATP5F1E | GSM4909282 | Human | Breast | IDC | 6.02e-23 | 5.15e-01 | -0.0288 |
514 | ATP5F1E | GSM4909285 | Human | Breast | IDC | 5.53e-35 | 2.69e-01 | 0.21 |
514 | ATP5F1E | GSM4909286 | Human | Breast | IDC | 5.99e-32 | 5.51e-01 | 0.1081 |
514 | ATP5F1E | GSM4909287 | Human | Breast | IDC | 2.39e-31 | 5.99e-01 | 0.2057 |
514 | ATP5F1E | GSM4909289 | Human | Breast | IDC | 1.97e-07 | 5.66e-01 | 0.1064 |
514 | ATP5F1E | GSM4909290 | Human | Breast | IDC | 1.59e-31 | 6.51e-01 | 0.2096 |
514 | ATP5F1E | GSM4909291 | Human | Breast | IDC | 6.17e-30 | 6.76e-01 | 0.1753 |
514 | ATP5F1E | GSM4909293 | Human | Breast | IDC | 7.20e-55 | 7.54e-01 | 0.1581 |
514 | ATP5F1E | GSM4909294 | Human | Breast | IDC | 9.29e-35 | 7.31e-01 | 0.2022 |
514 | ATP5F1E | GSM4909295 | Human | Breast | IDC | 3.16e-09 | 4.75e-01 | 0.0898 |
514 | ATP5F1E | GSM4909296 | Human | Breast | IDC | 1.30e-27 | 6.74e-01 | 0.1524 |
514 | ATP5F1E | GSM4909297 | Human | Breast | IDC | 5.82e-32 | 6.23e-01 | 0.1517 |
514 | ATP5F1E | GSM4909298 | Human | Breast | IDC | 5.11e-49 | 7.58e-01 | 0.1551 |
514 | ATP5F1E | GSM4909299 | Human | Breast | IDC | 5.87e-25 | 5.76e-01 | 0.035 |
514 | ATP5F1E | GSM4909300 | Human | Breast | IDC | 1.43e-13 | 5.15e-01 | 0.0334 |
514 | ATP5F1E | GSM4909301 | Human | Breast | IDC | 4.92e-108 | 9.88e-01 | 0.1577 |
514 | ATP5F1E | GSM4909302 | Human | Breast | IDC | 3.46e-20 | 5.01e-01 | 0.1545 |
514 | ATP5F1E | GSM4909303 | Human | Breast | IDC | 1.44e-14 | 6.74e-01 | 0.0438 |
514 | ATP5F1E | GSM4909304 | Human | Breast | IDC | 9.25e-81 | 8.84e-01 | 0.1636 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000914421 | Stomach | CSG | purine nucleoside triphosphate metabolic process | 25/1034 | 88/18723 | 5.73e-12 | 1.76e-09 | 25 |
GO:000920621 | Stomach | CSG | purine ribonucleoside triphosphate biosynthetic process | 22/1034 | 68/18723 | 5.99e-12 | 1.76e-09 | 22 |
GO:000920521 | Stomach | CSG | purine ribonucleoside triphosphate metabolic process | 24/1034 | 82/18723 | 7.49e-12 | 1.98e-09 | 24 |
GO:000914521 | Stomach | CSG | purine nucleoside triphosphate biosynthetic process | 22/1034 | 69/18723 | 8.34e-12 | 2.10e-09 | 22 |
GO:000675421 | Stomach | CSG | ATP biosynthetic process | 20/1034 | 57/18723 | 9.98e-12 | 2.40e-09 | 20 |
GO:004277621 | Stomach | CSG | mitochondrial ATP synthesis coupled proton transport | 12/1034 | 19/18723 | 2.66e-11 | 5.86e-09 | 12 |
GO:000920121 | Stomach | CSG | ribonucleoside triphosphate biosynthetic process | 22/1034 | 74/18723 | 3.97e-11 | 8.40e-09 | 22 |
GO:000919921 | Stomach | CSG | ribonucleoside triphosphate metabolic process | 24/1034 | 89/18723 | 5.12e-11 | 1.00e-08 | 24 |
GO:000914221 | Stomach | CSG | nucleoside triphosphate biosynthetic process | 23/1034 | 85/18723 | 1.20e-10 | 2.21e-08 | 23 |
GO:000683921 | Stomach | CSG | mitochondrial transport | 42/1034 | 254/18723 | 1.61e-10 | 2.75e-08 | 42 |
GO:000914121 | Stomach | CSG | nucleoside triphosphate metabolic process | 26/1034 | 112/18723 | 3.04e-10 | 4.87e-08 | 26 |
GO:000915221 | Stomach | CSG | purine ribonucleotide biosynthetic process | 28/1034 | 169/18723 | 1.72e-07 | 1.17e-05 | 28 |
GO:000915021 | Stomach | CSG | purine ribonucleotide metabolic process | 46/1034 | 368/18723 | 1.89e-07 | 1.26e-05 | 46 |
GO:000616321 | Stomach | CSG | purine nucleotide metabolic process | 48/1034 | 396/18723 | 2.61e-07 | 1.66e-05 | 48 |
GO:199054221 | Stomach | CSG | mitochondrial transmembrane transport | 20/1034 | 102/18723 | 6.40e-07 | 3.53e-05 | 20 |
GO:000925921 | Stomach | CSG | ribonucleotide metabolic process | 46/1034 | 385/18723 | 6.97e-07 | 3.75e-05 | 46 |
GO:000926021 | Stomach | CSG | ribonucleotide biosynthetic process | 28/1034 | 182/18723 | 8.22e-07 | 4.26e-05 | 28 |
GO:007252121 | Stomach | CSG | purine-containing compound metabolic process | 48/1034 | 416/18723 | 1.11e-06 | 5.64e-05 | 48 |
GO:001969321 | Stomach | CSG | ribose phosphate metabolic process | 46/1034 | 396/18723 | 1.54e-06 | 7.39e-05 | 46 |
GO:004639021 | Stomach | CSG | ribose phosphate biosynthetic process | 28/1034 | 190/18723 | 1.98e-06 | 9.02e-05 | 28 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
514 | ATP5F1E | TRANSPORTER | glucocorticoids | 26307125 | ||
514 | ATP5F1E | TRANSPORTER | etanercept | ETANERCEPT | 26307125 | |
514 | ATP5F1E | TRANSPORTER | adalimumab | ADALIMUMAB | 26307125 | |
514 | ATP5F1E | TRANSPORTER | certolizumab pegol | 26307125 | ||
514 | ATP5F1E | TRANSPORTER | methotrexate | METHOTREXATE | 26307125 | |
514 | ATP5F1E | TRANSPORTER | infliximab | INFLIXIMAB | 26307125 |
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