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Gene: FKBP1A |
Gene summary for FKBP1A |
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Gene information | Species | Human | Gene symbol | FKBP1A | Gene ID | 2280 |
Gene name | FKBP prolyl isomerase 1A | |
Gene Alias | FKBP-12 | |
Cytomap | 20p13 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | P62942 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2280 | FKBP1A | GSM4909280 | Human | Breast | Precancer | 2.88e-04 | -5.53e-01 | 0.0305 |
2280 | FKBP1A | GSM4909287 | Human | Breast | IDC | 2.16e-02 | -2.88e-01 | 0.2057 |
2280 | FKBP1A | GSM4909294 | Human | Breast | IDC | 7.64e-08 | -1.70e-01 | 0.2022 |
2280 | FKBP1A | GSM4909296 | Human | Breast | IDC | 1.09e-10 | -3.15e-01 | 0.1524 |
2280 | FKBP1A | GSM4909297 | Human | Breast | IDC | 1.65e-22 | -2.53e-01 | 0.1517 |
2280 | FKBP1A | GSM4909301 | Human | Breast | IDC | 6.99e-09 | -3.59e-01 | 0.1577 |
2280 | FKBP1A | GSM4909304 | Human | Breast | IDC | 2.97e-16 | -5.19e-01 | 0.1636 |
2280 | FKBP1A | GSM4909308 | Human | Breast | IDC | 5.52e-13 | 4.58e-01 | 0.158 |
2280 | FKBP1A | GSM4909311 | Human | Breast | IDC | 5.12e-40 | -3.15e-01 | 0.1534 |
2280 | FKBP1A | GSM4909312 | Human | Breast | IDC | 1.77e-40 | 5.33e-01 | 0.1552 |
2280 | FKBP1A | GSM4909316 | Human | Breast | IDC | 1.71e-04 | 1.73e-02 | 0.21 |
2280 | FKBP1A | GSM4909318 | Human | Breast | IDC | 9.20e-04 | 3.14e-01 | 0.2031 |
2280 | FKBP1A | GSM4909319 | Human | Breast | IDC | 1.48e-57 | -4.19e-01 | 0.1563 |
2280 | FKBP1A | GSM4909320 | Human | Breast | IDC | 1.82e-17 | -7.62e-01 | 0.1575 |
2280 | FKBP1A | GSM4909321 | Human | Breast | IDC | 1.89e-22 | -3.10e-01 | 0.1559 |
2280 | FKBP1A | brca1 | Human | Breast | Precancer | 1.96e-15 | 4.85e-01 | -0.0338 |
2280 | FKBP1A | brca2 | Human | Breast | Precancer | 1.87e-02 | 2.21e-01 | -0.024 |
2280 | FKBP1A | M1 | Human | Breast | IDC | 6.06e-08 | -4.71e-01 | 0.1577 |
2280 | FKBP1A | M2 | Human | Breast | IDC | 1.89e-09 | 4.08e-01 | 0.21 |
2280 | FKBP1A | NCCBC14 | Human | Breast | DCIS | 1.60e-15 | -4.06e-01 | 0.2021 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160419 | Skin | cSCC | protein maturation | 117/4864 | 294/18723 | 1.27e-07 | 2.93e-06 | 117 |
GO:190332217 | Skin | cSCC | positive regulation of protein modification by small protein conjugation or removal | 64/4864 | 138/18723 | 1.79e-07 | 3.94e-06 | 64 |
GO:000647024 | Skin | cSCC | protein dephosphorylation | 111/4864 | 281/18723 | 4.10e-07 | 7.96e-06 | 111 |
GO:004593628 | Skin | cSCC | negative regulation of phosphate metabolic process | 160/4864 | 441/18723 | 8.89e-07 | 1.63e-05 | 160 |
GO:00004136 | Skin | cSCC | protein peptidyl-prolyl isomerization | 26/4864 | 42/18723 | 9.92e-07 | 1.78e-05 | 26 |
GO:001056328 | Skin | cSCC | negative regulation of phosphorus metabolic process | 160/4864 | 442/18723 | 1.04e-06 | 1.85e-05 | 160 |
GO:005109927 | Skin | cSCC | positive regulation of binding | 74/4864 | 173/18723 | 1.09e-06 | 1.93e-05 | 74 |
GO:003139817 | Skin | cSCC | positive regulation of protein ubiquitination | 54/4864 | 119/18723 | 3.61e-06 | 5.49e-05 | 54 |
GO:004339325 | Skin | cSCC | regulation of protein binding | 79/4864 | 196/18723 | 7.59e-06 | 1.04e-04 | 79 |
GO:0035304112 | Skin | cSCC | regulation of protein dephosphorylation | 41/4864 | 90/18723 | 4.61e-05 | 4.80e-04 | 41 |
GO:007155917 | Skin | cSCC | response to transforming growth factor beta | 95/4864 | 256/18723 | 5.21e-05 | 5.31e-04 | 95 |
GO:007156025 | Skin | cSCC | cellular response to transforming growth factor beta stimulus | 92/4864 | 250/18723 | 9.65e-05 | 8.99e-04 | 92 |
GO:005134627 | Skin | cSCC | negative regulation of hydrolase activity | 130/4864 | 379/18723 | 1.74e-04 | 1.49e-03 | 130 |
GO:003530818 | Skin | cSCC | negative regulation of protein dephosphorylation | 19/4864 | 34/18723 | 2.03e-04 | 1.69e-03 | 19 |
GO:199000024 | Skin | cSCC | amyloid fibril formation | 18/4864 | 34/18723 | 7.18e-04 | 5.04e-03 | 18 |
GO:003530514 | Skin | cSCC | negative regulation of dephosphorylation | 22/4864 | 45/18723 | 8.01e-04 | 5.55e-03 | 22 |
GO:0035303112 | Skin | cSCC | regulation of dephosphorylation | 49/4864 | 128/18723 | 1.46e-03 | 9.17e-03 | 49 |
GO:001631115 | Skin | cSCC | dephosphorylation | 134/4864 | 417/18723 | 2.65e-03 | 1.50e-02 | 134 |
GO:000717917 | Skin | cSCC | transforming growth factor beta receptor signaling pathway | 69/4864 | 198/18723 | 3.39e-03 | 1.84e-02 | 69 |
GO:005123527 | Skin | cSCC | maintenance of location | 106/4864 | 327/18723 | 5.17e-03 | 2.61e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FKBP1A | SNV | Missense_Mutation | novel | c.206N>G | p.Val69Gly | p.V69G | P62942 | protein_coding | deleterious(0) | possibly_damaging(0.747) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FKBP1A | SNV | Missense_Mutation | c.298N>C | p.Phe100Leu | p.F100L | P62942 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FKBP1A | SNV | Missense_Mutation | c.116N>A | p.Ser39Tyr | p.S39Y | P62942 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
FKBP1A | SNV | Missense_Mutation | c.116N>G | p.Ser39Cys | p.S39C | P62942 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-CL-5917-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
FKBP1A | SNV | Missense_Mutation | c.173N>A | p.Arg58Gln | p.R58Q | P62942 | protein_coding | tolerated(0.12) | benign(0.309) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
FKBP1A | SNV | Missense_Mutation | novel | c.253G>A | p.Ala85Thr | p.A85T | P62942 | protein_coding | deleterious(0.04) | benign(0.009) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FKBP1A | SNV | Missense_Mutation | novel | c.240T>G | p.Asp80Glu | p.D80E | P62942 | protein_coding | tolerated(0.16) | benign(0.029) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
FKBP1A | SNV | Missense_Mutation | novel | c.263N>G | p.His88Arg | p.H88R | P62942 | protein_coding | tolerated(0.22) | probably_damaging(0.981) | TCGA-66-2763-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FKBP1A | SNV | Missense_Mutation | c.208N>T | p.Gly70Cys | p.G70C | P62942 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CD-8529-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | epirubicin | CR | |
FKBP1A | SNV | Missense_Mutation | rs760096309 | c.121N>T | p.Arg41Trp | p.R41W | P62942 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-CD-8531-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | epirubicin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | inhibitor | CHEMBL3545142 | OLOCROLIMUS | |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | SCY-641 | RUCLOSPORIN | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | AP1903 | RIMIDUCID | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | Rapamycin | SIROLIMUS | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | SIROLIMUS | SIROLIMUS | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | inhibitor | CHEMBL413 | SIROLIMUS | |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | TACROLIMUS | TACROLIMUS | ||
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | AZD-8055 | AZD-8055 | 23375793 | |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | inhibitor | 178102653 | SIROLIMUS | |
2280 | FKBP1A | DRUGGABLE GENOME, ENZYME, KINASE | EVEROLIMUS | EVEROLIMUS | 24836070 |
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