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Gene: SRF |
Gene summary for SRF |
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Gene information | Species | Human | Gene symbol | SRF | Gene ID | 6722 |
Gene name | serum response factor | |
Gene Alias | MCM1 | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | B4DU24 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6722 | SRF | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.08e-04 | 3.42e-01 | -0.0811 |
6722 | SRF | HTA11_696_2000001011 | Human | Colorectum | AD | 7.01e-05 | 2.10e-01 | -0.1464 |
6722 | SRF | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.39e-10 | 3.69e-01 | -0.059 |
6722 | SRF | HTA11_866_3004761011 | Human | Colorectum | AD | 3.51e-03 | 2.42e-01 | 0.096 |
6722 | SRF | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.53e-07 | 2.32e-01 | 0.0674 |
6722 | SRF | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.59e-15 | 4.12e-01 | 0.294 |
6722 | SRF | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.38e-24 | 5.53e-01 | 0.3859 |
6722 | SRF | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.97e-09 | 4.77e-01 | 0.2585 |
6722 | SRF | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.10e-04 | 1.99e-01 | 0.3005 |
6722 | SRF | LZE8T | Human | Esophagus | ESCC | 1.64e-04 | 4.89e-02 | 0.067 |
6722 | SRF | LZE20T | Human | Esophagus | ESCC | 2.83e-02 | -4.23e-02 | 0.0662 |
6722 | SRF | LZE24T | Human | Esophagus | ESCC | 8.90e-06 | 2.54e-01 | 0.0596 |
6722 | SRF | P2T-E | Human | Esophagus | ESCC | 4.47e-11 | 9.40e-02 | 0.1177 |
6722 | SRF | P4T-E | Human | Esophagus | ESCC | 6.97e-14 | 2.19e-01 | 0.1323 |
6722 | SRF | P5T-E | Human | Esophagus | ESCC | 2.95e-12 | 9.77e-02 | 0.1327 |
6722 | SRF | P8T-E | Human | Esophagus | ESCC | 7.41e-05 | 3.32e-02 | 0.0889 |
6722 | SRF | P9T-E | Human | Esophagus | ESCC | 1.03e-09 | 1.76e-02 | 0.1131 |
6722 | SRF | P10T-E | Human | Esophagus | ESCC | 5.36e-14 | 1.43e-01 | 0.116 |
6722 | SRF | P11T-E | Human | Esophagus | ESCC | 5.84e-06 | 3.81e-02 | 0.1426 |
6722 | SRF | P12T-E | Human | Esophagus | ESCC | 4.59e-14 | 1.82e-02 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007048228 | Thyroid | ATC | response to oxygen levels | 193/6293 | 347/18723 | 1.83e-17 | 1.93e-15 | 193 |
GO:003158928 | Thyroid | ATC | cell-substrate adhesion | 195/6293 | 363/18723 | 1.58e-15 | 1.17e-13 | 195 |
GO:003629328 | Thyroid | ATC | response to decreased oxygen levels | 177/6293 | 322/18723 | 1.81e-15 | 1.32e-13 | 177 |
GO:0007015210 | Thyroid | ATC | actin filament organization | 227/6293 | 442/18723 | 5.96e-15 | 3.85e-13 | 227 |
GO:000166628 | Thyroid | ATC | response to hypoxia | 169/6293 | 307/18723 | 6.58e-15 | 4.12e-13 | 169 |
GO:001604927 | Thyroid | ATC | cell growth | 241/6293 | 482/18723 | 4.27e-14 | 2.35e-12 | 241 |
GO:003134623 | Thyroid | ATC | positive regulation of cell projection organization | 186/6293 | 353/18723 | 7.99e-14 | 4.23e-12 | 186 |
GO:003466021 | Thyroid | ATC | ncRNA metabolic process | 240/6293 | 485/18723 | 2.03e-13 | 9.91e-12 | 240 |
GO:004227435 | Thyroid | ATC | ribosomal small subunit biogenesis | 55/6293 | 73/18723 | 3.33e-13 | 1.55e-11 | 55 |
GO:004206034 | Thyroid | ATC | wound healing | 210/6293 | 422/18723 | 3.33e-12 | 1.37e-10 | 210 |
GO:0007160111 | Thyroid | ATC | cell-matrix adhesion | 128/6293 | 233/18723 | 1.49e-11 | 5.41e-10 | 128 |
GO:0071496210 | Thyroid | ATC | cellular response to external stimulus | 165/6293 | 320/18723 | 2.01e-11 | 7.23e-10 | 165 |
GO:003253526 | Thyroid | ATC | regulation of cellular component size | 191/6293 | 383/18723 | 2.51e-11 | 8.69e-10 | 191 |
GO:000166731 | Thyroid | ATC | ameboidal-type cell migration | 228/6293 | 475/18723 | 3.72e-11 | 1.22e-09 | 228 |
GO:000170126 | Thyroid | ATC | in utero embryonic development | 183/6293 | 367/18723 | 6.62e-11 | 2.11e-09 | 183 |
GO:004873233 | Thyroid | ATC | gland development | 210/6293 | 436/18723 | 1.50e-10 | 4.59e-09 | 210 |
GO:000155826 | Thyroid | ATC | regulation of cell growth | 201/6293 | 414/18723 | 1.57e-10 | 4.76e-09 | 201 |
GO:001097523 | Thyroid | ATC | regulation of neuron projection development | 212/6293 | 445/18723 | 4.16e-10 | 1.14e-08 | 212 |
GO:006156423 | Thyroid | ATC | axon development | 220/6293 | 467/18723 | 6.85e-10 | 1.80e-08 | 220 |
GO:000756829 | Thyroid | ATC | aging | 166/6293 | 339/18723 | 2.79e-09 | 6.60e-08 | 166 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05166 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa051661 | Colorectum | AD | Human T-cell leukemia virus 1 infection | 72/2092 | 222/8465 | 5.24e-03 | 2.44e-02 | 1.55e-02 | 72 |
hsa051662 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa04022 | Colorectum | MSS | cGMP-PKG signaling pathway | 51/1875 | 167/8465 | 6.83e-03 | 2.73e-02 | 1.67e-02 | 51 |
hsa051663 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa040221 | Colorectum | MSS | cGMP-PKG signaling pathway | 51/1875 | 167/8465 | 6.83e-03 | 2.73e-02 | 1.67e-02 | 51 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0401014 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa05166113 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
hsa0520314 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0401015 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
SRF | STM | Thyroid | ADJ | TFCP2L1,AC016831.1,ST7-AS1, etc. | 5.35e-01 | ![]() |
SRF | STM | Thyroid | goiters | TFCP2L1,AC016831.1,ST7-AS1, etc. | 6.93e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SRF | SNV | Missense_Mutation | novel | c.1081C>G | p.Gln361Glu | p.Q361E | P11831 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SRF | SNV | Missense_Mutation | novel | c.627G>C | p.Glu209Asp | p.E209D | P11831 | protein_coding | tolerated(0.14) | benign(0.269) | TCGA-BH-A0BF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SRF | SNV | Missense_Mutation | novel | c.1313N>T | p.Pro438Leu | p.P438L | P11831 | protein_coding | deleterious(0) | benign(0.015) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD |
SRF | SNV | Missense_Mutation | novel | c.857N>G | p.Ser286Cys | p.S286C | P11831 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
SRF | SNV | Missense_Mutation | novel | c.655C>A | p.Leu219Ile | p.L219I | P11831 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SRF | SNV | Missense_Mutation | rs761821794 | c.1174N>A | p.Ala392Thr | p.A392T | P11831 | protein_coding | tolerated(0.12) | probably_damaging(0.985) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SRF | SNV | Missense_Mutation | c.1036A>G | p.Met346Val | p.M346V | P11831 | protein_coding | tolerated(0.14) | possibly_damaging(0.878) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
SRF | SNV | Missense_Mutation | c.1504N>A | p.Ala502Thr | p.A502T | P11831 | protein_coding | tolerated_low_confidence(0.76) | benign(0) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SRF | SNV | Missense_Mutation | c.1328T>C | p.Val443Ala | p.V443A | P11831 | protein_coding | tolerated(0.1) | probably_damaging(0.956) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SRF | SNV | Missense_Mutation | c.1097C>T | p.Pro366Leu | p.P366L | P11831 | protein_coding | tolerated(0.08) | benign(0.115) | TCGA-A5-A0G9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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