Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0070972111 | Thyroid | PTC | protein localization to endoplasmic reticulum | 51/5968 | 74/18723 | 6.57e-11 | 2.30e-09 | 51 |
GO:0032535112 | Thyroid | PTC | regulation of cellular component size | 181/5968 | 383/18723 | 1.70e-10 | 5.64e-09 | 181 |
GO:0034620113 | Thyroid | PTC | cellular response to unfolded protein | 60/5968 | 96/18723 | 6.36e-10 | 1.97e-08 | 60 |
GO:1905897113 | Thyroid | PTC | regulation of response to endoplasmic reticulum stress | 52/5968 | 82/18723 | 4.18e-09 | 1.10e-07 | 52 |
GO:0030968111 | Thyroid | PTC | endoplasmic reticulum unfolded protein response | 48/5968 | 74/18723 | 5.52e-09 | 1.41e-07 | 48 |
GO:0006984110 | Thyroid | PTC | ER-nucleus signaling pathway | 32/5968 | 46/18723 | 1.72e-07 | 3.21e-06 | 32 |
GO:1903573113 | Thyroid | PTC | negative regulation of response to endoplasmic reticulum stress | 30/5968 | 44/18723 | 8.27e-07 | 1.27e-05 | 30 |
GO:007005925 | Thyroid | PTC | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 39/5968 | 63/18723 | 8.90e-07 | 1.35e-05 | 39 |
GO:003530427 | Thyroid | PTC | regulation of protein dephosphorylation | 51/5968 | 90/18723 | 1.01e-06 | 1.50e-05 | 51 |
GO:003530324 | Thyroid | PTC | regulation of dephosphorylation | 67/5968 | 128/18723 | 1.19e-06 | 1.72e-05 | 67 |
GO:001631116 | Thyroid | PTC | dephosphorylation | 174/5968 | 417/18723 | 1.20e-05 | 1.31e-04 | 174 |
GO:00435557 | Thyroid | PTC | regulation of translation in response to stress | 16/5968 | 20/18723 | 1.31e-05 | 1.42e-04 | 16 |
GO:014046714 | Thyroid | PTC | integrated stress response signaling | 17/5968 | 22/18723 | 1.58e-05 | 1.67e-04 | 17 |
GO:000647020 | Thyroid | PTC | protein dephosphorylation | 123/5968 | 281/18723 | 1.69e-05 | 1.77e-04 | 123 |
GO:00435587 | Thyroid | PTC | regulation of translational initiation in response to stress | 12/5968 | 14/18723 | 4.96e-05 | 4.42e-04 | 12 |
GO:001092116 | Thyroid | PTC | regulation of phosphatase activity | 44/5968 | 84/18723 | 7.53e-05 | 6.48e-04 | 44 |
GO:190010117 | Thyroid | PTC | regulation of endoplasmic reticulum unfolded protein response | 20/5968 | 30/18723 | 9.53e-05 | 7.85e-04 | 20 |
GO:004366620 | Thyroid | PTC | regulation of phosphoprotein phosphatase activity | 32/5968 | 58/18723 | 2.01e-04 | 1.50e-03 | 32 |
GO:003649914 | Thyroid | PTC | PERK-mediated unfolded protein response | 13/5968 | 18/18723 | 5.21e-04 | 3.37e-03 | 13 |
GO:00353075 | Thyroid | PTC | positive regulation of protein dephosphorylation | 25/5968 | 45/18723 | 8.54e-04 | 5.23e-03 | 25 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414118 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414119 | Breast | Precancer | Protein processing in endoplasmic reticulum | 33/684 | 174/8465 | 2.78e-06 | 3.83e-05 | 2.94e-05 | 33 |
hsa0414124 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414134 | Breast | IDC | Protein processing in endoplasmic reticulum | 36/867 | 174/8465 | 2.73e-05 | 2.86e-04 | 2.14e-04 | 36 |
hsa0414143 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414153 | Breast | DCIS | Protein processing in endoplasmic reticulum | 36/846 | 174/8465 | 1.60e-05 | 1.91e-04 | 1.41e-04 | 36 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0414125 | Cervix | HSIL_HPV | Protein processing in endoplasmic reticulum | 21/459 | 174/8465 | 4.54e-04 | 3.80e-03 | 3.07e-03 | 21 |
hsa0414135 | Cervix | HSIL_HPV | Protein processing in endoplasmic reticulum | 21/459 | 174/8465 | 4.54e-04 | 3.80e-03 | 3.07e-03 | 21 |
hsa0414126 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa04141111 | Endometrium | AEH | Protein processing in endoplasmic reticulum | 62/1197 | 174/8465 | 5.97e-13 | 1.39e-11 | 1.01e-11 | 62 |
hsa0414127 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414136 | Endometrium | EEC | Protein processing in endoplasmic reticulum | 64/1237 | 174/8465 | 2.17e-13 | 5.09e-12 | 3.80e-12 | 64 |
hsa0414139 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa04141114 | Esophagus | HGIN | Protein processing in endoplasmic reticulum | 67/1383 | 174/8465 | 1.06e-12 | 2.16e-11 | 1.72e-11 | 67 |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0414114 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
hsa0414115 | Liver | Cirrhotic | Protein processing in endoplasmic reticulum | 114/2530 | 174/8465 | 1.16e-22 | 9.67e-21 | 5.96e-21 | 114 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1R15A | SNV | Missense_Mutation | novel | c.682N>A | p.Glu228Lys | p.E228K | O75807 | protein_coding | deleterious(0.03) | probably_damaging(0.914) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
PPP1R15A | SNV | Missense_Mutation | novel | c.776N>T | p.Ser259Phe | p.S259F | O75807 | protein_coding | deleterious(0) | benign(0.087) | TCGA-GM-A2DF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | CR |
PPP1R15A | insertion | Nonsense_Mutation | novel | c.2017_2018insATAATGAATAAATAAATAAATAAATA | p.Arg673HisfsTer4 | p.R673Hfs*4 | O75807 | protein_coding | | | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
PPP1R15A | deletion | Frame_Shift_Del | rs764798313 | c.996delN | p.Pro334HisfsTer6 | p.P334Hfs*6 | O75807 | protein_coding | | | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1R15A | deletion | Frame_Shift_Del | | c.1977_1992delNNNNNNNNNNNNNNNN | p.Ser660LeufsTer26 | p.S660Lfs*26 | O75807 | protein_coding | | | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD |
PPP1R15A | SNV | Missense_Mutation | novel | c.545C>T | p.Ser182Leu | p.S182L | O75807 | protein_coding | deleterious(0.03) | possibly_damaging(0.588) | TCGA-C5-A2LV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PPP1R15A | SNV | Missense_Mutation | | c.1412C>T | p.Ser471Phe | p.S471F | O75807 | protein_coding | deleterious(0.04) | benign(0.038) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
PPP1R15A | SNV | Missense_Mutation | | c.403N>A | p.Ala135Thr | p.A135T | O75807 | protein_coding | tolerated(1) | benign(0.003) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PPP1R15A | SNV | Missense_Mutation | novel | c.849N>T | p.Glu283Asp | p.E283D | O75807 | protein_coding | tolerated(0.42) | benign(0.003) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1R15A | SNV | Missense_Mutation | | c.697G>A | p.Glu233Lys | p.E233K | O75807 | protein_coding | tolerated(0.06) | possibly_damaging(0.876) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |