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Gene: NOP53 |
Gene summary for NOP53 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | NOP53 | Gene ID | 29997 |
| Gene name | NOP53 ribosome biogenesis factor | |
| Gene Alias | GLTSCR2 | |
| Cytomap | 19q13.33 | |
| Gene Type | protein-coding | GO ID | GO:0000027 | UniProtAcc | Q9NZM5 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 29997 | NOP53 | GSM4909281 | Human | Breast | IDC | 2.59e-17 | -1.95e-01 | 0.21 |
| 29997 | NOP53 | GSM4909282 | Human | Breast | IDC | 1.33e-16 | -4.27e-01 | -0.0288 |
| 29997 | NOP53 | GSM4909285 | Human | Breast | IDC | 1.01e-26 | 9.00e-02 | 0.21 |
| 29997 | NOP53 | GSM4909286 | Human | Breast | IDC | 5.34e-29 | 6.51e-01 | 0.1081 |
| 29997 | NOP53 | GSM4909287 | Human | Breast | IDC | 4.59e-08 | -4.97e-01 | 0.2057 |
| 29997 | NOP53 | GSM4909290 | Human | Breast | IDC | 1.74e-05 | -2.74e-01 | 0.2096 |
| 29997 | NOP53 | GSM4909293 | Human | Breast | IDC | 3.04e-30 | -4.66e-01 | 0.1581 |
| 29997 | NOP53 | GSM4909294 | Human | Breast | IDC | 3.09e-19 | -6.15e-01 | 0.2022 |
| 29997 | NOP53 | GSM4909296 | Human | Breast | IDC | 3.40e-02 | -3.38e-01 | 0.1524 |
| 29997 | NOP53 | GSM4909298 | Human | Breast | IDC | 2.52e-21 | 1.92e-01 | 0.1551 |
| 29997 | NOP53 | GSM4909299 | Human | Breast | IDC | 1.92e-11 | 3.45e-01 | 0.035 |
| 29997 | NOP53 | GSM4909300 | Human | Breast | IDC | 1.58e-03 | 3.79e-01 | 0.0334 |
| 29997 | NOP53 | GSM4909301 | Human | Breast | IDC | 8.87e-12 | -4.52e-01 | 0.1577 |
| 29997 | NOP53 | GSM4909304 | Human | Breast | IDC | 2.19e-27 | -5.62e-01 | 0.1636 |
| 29997 | NOP53 | GSM4909305 | Human | Breast | IDC | 2.57e-20 | 6.04e-01 | 0.0436 |
| 29997 | NOP53 | GSM4909306 | Human | Breast | IDC | 7.83e-08 | 1.64e-01 | 0.1564 |
| 29997 | NOP53 | GSM4909307 | Human | Breast | IDC | 1.20e-03 | -1.48e-02 | 0.1569 |
| 29997 | NOP53 | GSM4909308 | Human | Breast | IDC | 2.35e-24 | 2.05e-01 | 0.158 |
| 29997 | NOP53 | GSM4909311 | Human | Breast | IDC | 2.43e-17 | -2.17e-01 | 0.1534 |
| 29997 | NOP53 | GSM4909313 | Human | Breast | IDC | 8.45e-04 | 3.70e-01 | 0.0391 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:002261832 | Liver | Cyst | ribonucleoprotein complex assembly | 27/496 | 220/18723 | 3.54e-11 | 9.46e-09 | 27 |
| GO:004227332 | Liver | Cyst | ribosomal large subunit biogenesis | 16/496 | 72/18723 | 4.86e-11 | 1.22e-08 | 16 |
| GO:000609132 | Liver | Cyst | generation of precursor metabolites and energy | 40/496 | 490/18723 | 3.01e-10 | 6.43e-08 | 40 |
| GO:001607221 | Liver | Cyst | rRNA metabolic process | 24/496 | 236/18723 | 1.94e-08 | 3.06e-06 | 24 |
| GO:190332032 | Liver | Cyst | regulation of protein modification by small protein conjugation or removal | 24/496 | 242/18723 | 3.15e-08 | 4.64e-06 | 24 |
| GO:00063643 | Liver | Cyst | rRNA processing | 23/496 | 225/18723 | 3.48e-08 | 4.80e-06 | 23 |
| GO:000002732 | Liver | Cyst | ribosomal large subunit assembly | 8/496 | 27/18723 | 3.27e-07 | 3.67e-05 | 8 |
| GO:190179632 | Liver | Cyst | regulation of signal transduction by p53 class mediator | 12/496 | 93/18723 | 6.22e-06 | 4.83e-04 | 12 |
| GO:004586132 | Liver | Cyst | negative regulation of proteolysis | 25/496 | 351/18723 | 8.03e-06 | 5.72e-04 | 25 |
| GO:005082132 | Liver | Cyst | protein stabilization | 17/496 | 191/18723 | 1.38e-05 | 9.07e-04 | 17 |
| GO:007233132 | Liver | Cyst | signal transduction by p53 class mediator | 15/496 | 163/18723 | 2.97e-05 | 1.78e-03 | 15 |
| GO:200005932 | Liver | Cyst | negative regulation of ubiquitin-dependent protein catabolic process | 8/496 | 48/18723 | 3.41e-05 | 1.94e-03 | 8 |
| GO:003164732 | Liver | Cyst | regulation of protein stability | 21/496 | 298/18723 | 4.94e-05 | 2.67e-03 | 21 |
| GO:00344703 | Liver | Cyst | ncRNA processing | 25/496 | 395/18723 | 5.78e-05 | 3.01e-03 | 25 |
| GO:00346602 | Liver | Cyst | ncRNA metabolic process | 28/496 | 485/18723 | 1.05e-04 | 4.67e-03 | 28 |
| GO:004217632 | Liver | Cyst | regulation of protein catabolic process | 24/496 | 391/18723 | 1.30e-04 | 5.59e-03 | 24 |
| GO:190336331 | Liver | Cyst | negative regulation of cellular protein catabolic process | 9/496 | 75/18723 | 1.59e-04 | 6.53e-03 | 9 |
| GO:190336232 | Liver | Cyst | regulation of cellular protein catabolic process | 18/496 | 255/18723 | 1.65e-04 | 6.59e-03 | 18 |
| GO:0043491 | Liver | Cyst | protein kinase B signaling | 16/496 | 211/18723 | 1.67e-04 | 6.59e-03 | 16 |
| GO:190305131 | Liver | Cyst | negative regulation of proteolysis involved in cellular protein catabolic process | 8/496 | 64/18723 | 2.76e-04 | 9.36e-03 | 8 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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