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Gene: CCT5 |
Gene summary for CCT5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CCT5 | Gene ID | 22948 |
| Gene name | chaperonin containing TCP1 subunit 5 | |
| Gene Alias | CCT-epsilon | |
| Cytomap | 5p15.2 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DX08 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 22948 | CCT5 | GSM4909282 | Human | Breast | IDC | 2.85e-20 | 5.90e-01 | -0.0288 |
| 22948 | CCT5 | GSM4909285 | Human | Breast | IDC | 4.43e-23 | 6.30e-01 | 0.21 |
| 22948 | CCT5 | GSM4909286 | Human | Breast | IDC | 1.57e-03 | -6.90e-02 | 0.1081 |
| 22948 | CCT5 | GSM4909288 | Human | Breast | IDC | 3.72e-04 | 3.12e-01 | 0.0988 |
| 22948 | CCT5 | GSM4909293 | Human | Breast | IDC | 9.82e-03 | -1.12e-01 | 0.1581 |
| 22948 | CCT5 | GSM4909296 | Human | Breast | IDC | 2.19e-11 | -3.38e-01 | 0.1524 |
| 22948 | CCT5 | GSM4909297 | Human | Breast | IDC | 3.63e-07 | -8.96e-02 | 0.1517 |
| 22948 | CCT5 | GSM4909301 | Human | Breast | IDC | 2.05e-04 | -2.72e-01 | 0.1577 |
| 22948 | CCT5 | GSM4909307 | Human | Breast | IDC | 6.30e-06 | -2.84e-01 | 0.1569 |
| 22948 | CCT5 | GSM4909311 | Human | Breast | IDC | 1.89e-25 | -2.72e-01 | 0.1534 |
| 22948 | CCT5 | GSM4909312 | Human | Breast | IDC | 1.01e-06 | -4.73e-02 | 0.1552 |
| 22948 | CCT5 | GSM4909313 | Human | Breast | IDC | 6.29e-05 | -2.99e-01 | 0.0391 |
| 22948 | CCT5 | GSM4909318 | Human | Breast | IDC | 3.11e-09 | 7.13e-01 | 0.2031 |
| 22948 | CCT5 | GSM4909319 | Human | Breast | IDC | 8.51e-27 | -3.80e-01 | 0.1563 |
| 22948 | CCT5 | GSM4909320 | Human | Breast | IDC | 1.30e-02 | -3.16e-01 | 0.1575 |
| 22948 | CCT5 | GSM4909321 | Human | Breast | IDC | 9.26e-09 | -1.47e-01 | 0.1559 |
| 22948 | CCT5 | brca1 | Human | Breast | Precancer | 8.88e-31 | 6.44e-01 | -0.0338 |
| 22948 | CCT5 | brca2 | Human | Breast | Precancer | 2.36e-11 | 4.02e-01 | -0.024 |
| 22948 | CCT5 | brca3 | Human | Breast | Precancer | 4.68e-05 | 3.82e-01 | -0.0263 |
| 22948 | CCT5 | M2 | Human | Breast | IDC | 1.03e-18 | 7.91e-01 | 0.21 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00322009 | Thyroid | PTC | telomere organization | 74/5968 | 159/18723 | 7.46e-05 | 6.43e-04 | 74 |
| GO:0071897110 | Thyroid | PTC | DNA biosynthetic process | 82/5968 | 180/18723 | 7.98e-05 | 6.81e-04 | 82 |
| GO:003221218 | Thyroid | PTC | positive regulation of telomere maintenance via telomerase | 22/5968 | 34/18723 | 8.41e-05 | 7.03e-04 | 22 |
| GO:007020310 | Thyroid | PTC | regulation of establishment of protein localization to telomere | 10/5968 | 11/18723 | 8.42e-05 | 7.03e-04 | 10 |
| GO:190486917 | Thyroid | PTC | regulation of protein localization to Cajal body | 10/5968 | 11/18723 | 8.42e-05 | 7.03e-04 | 10 |
| GO:190487117 | Thyroid | PTC | positive regulation of protein localization to Cajal body | 10/5968 | 11/18723 | 8.42e-05 | 7.03e-04 | 10 |
| GO:190485119 | Thyroid | PTC | positive regulation of establishment of protein localization to telomere | 9/5968 | 10/18723 | 2.41e-04 | 1.74e-03 | 9 |
| GO:2000573111 | Thyroid | PTC | positive regulation of DNA biosynthetic process | 35/5968 | 66/18723 | 2.91e-04 | 2.06e-03 | 35 |
| GO:007020220 | Thyroid | PTC | regulation of establishment of protein localization to chromosome | 10/5968 | 12/18723 | 3.59e-04 | 2.44e-03 | 10 |
| GO:190340517 | Thyroid | PTC | protein localization to nuclear body | 10/5968 | 12/18723 | 3.59e-04 | 2.44e-03 | 10 |
| GO:190486717 | Thyroid | PTC | protein localization to Cajal body | 10/5968 | 12/18723 | 3.59e-04 | 2.44e-03 | 10 |
| GO:00702009 | Thyroid | PTC | establishment of protein localization to telomere | 12/5968 | 16/18723 | 4.97e-04 | 3.25e-03 | 12 |
| GO:00345026 | Thyroid | PTC | protein localization to chromosome | 43/5968 | 92/18723 | 2.00e-03 | 1.07e-02 | 43 |
| GO:00701998 | Thyroid | PTC | establishment of protein localization to chromosome | 15/5968 | 25/18723 | 3.45e-03 | 1.67e-02 | 15 |
| GO:19019989 | Thyroid | PTC | toxin transport | 21/5968 | 40/18723 | 5.37e-03 | 2.47e-02 | 21 |
| GO:007259429 | Thyroid | ATC | establishment of protein localization to organelle | 247/6293 | 422/18723 | 2.88e-26 | 1.40e-23 | 247 |
| GO:000645733 | Thyroid | ATC | protein folding | 140/6293 | 212/18723 | 3.46e-22 | 8.09e-20 | 140 |
| GO:003450423 | Thyroid | ATC | protein localization to nucleus | 175/6293 | 290/18723 | 6.23e-21 | 1.23e-18 | 175 |
| GO:000640326 | Thyroid | ATC | RNA localization | 132/6293 | 201/18723 | 1.13e-20 | 1.93e-18 | 132 |
| GO:1903829210 | Thyroid | ATC | positive regulation of cellular protein localization | 167/6293 | 276/18723 | 3.32e-20 | 5.38e-18 | 167 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CCT5 | SNV | Missense_Mutation | rs762786367 | c.1046N>T | p.Thr349Ile | p.T349I | P48643 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
| CCT5 | SNV | Missense_Mutation | c.1031G>T | p.Arg344Met | p.R344M | P48643 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCT5 | SNV | Missense_Mutation | c.1018C>T | p.Arg340Trp | p.R340W | P48643 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| CCT5 | SNV | Missense_Mutation | c.1018N>T | p.Arg340Trp | p.R340W | P48643 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| CCT5 | SNV | Missense_Mutation | rs768768696 | c.1006G>A | p.Ala336Thr | p.A336T | P48643 | protein_coding | tolerated(0.07) | benign(0.325) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CCT5 | SNV | Missense_Mutation | novel | c.359N>T | p.Ala120Val | p.A120V | P48643 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| CCT5 | SNV | Missense_Mutation | rs768768696 | c.1006N>A | p.Ala336Thr | p.A336T | P48643 | protein_coding | tolerated(0.07) | benign(0.325) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| CCT5 | SNV | Missense_Mutation | c.338N>A | p.Ala113Asp | p.A113D | P48643 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| CCT5 | SNV | Missense_Mutation | novel | c.819N>G | p.Asp273Glu | p.D273E | P48643 | protein_coding | tolerated(1) | benign(0.019) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| CCT5 | SNV | Missense_Mutation | c.1400N>A | p.Gly467Asp | p.G467D | P48643 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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