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Gene: ANG |
Gene summary for ANG |
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Gene information | Species | Human | Gene symbol | ANG | Gene ID | 283 |
Gene name | angiogenin | |
Gene Alias | ALS9 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P03950 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
283 | ANG | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.41e-07 | 1.84e-01 | 0.0155 |
283 | ANG | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.14e-15 | 4.33e-01 | -0.1808 |
283 | ANG | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.84e-10 | 3.71e-01 | -0.0811 |
283 | ANG | HTA11_78_2000001011 | Human | Colorectum | AD | 2.54e-12 | 3.19e-01 | -0.1088 |
283 | ANG | HTA11_347_2000001011 | Human | Colorectum | AD | 1.18e-22 | 4.53e-01 | -0.1954 |
283 | ANG | HTA11_411_2000001011 | Human | Colorectum | SER | 3.33e-15 | 1.24e+00 | -0.2602 |
283 | ANG | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.76e-08 | 6.35e-01 | -0.2196 |
283 | ANG | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.49e-10 | 3.09e-01 | -0.1207 |
283 | ANG | HTA11_83_2000001011 | Human | Colorectum | SER | 1.12e-08 | 3.22e-01 | -0.1526 |
283 | ANG | HTA11_696_2000001011 | Human | Colorectum | AD | 5.54e-31 | 5.89e-01 | -0.1464 |
283 | ANG | HTA11_866_2000001011 | Human | Colorectum | AD | 1.42e-14 | 3.27e-01 | -0.1001 |
283 | ANG | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.65e-19 | 4.31e-01 | -0.059 |
283 | ANG | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.72e-05 | 3.79e-01 | -0.1706 |
283 | ANG | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.47e-14 | 5.15e-01 | -0.2061 |
283 | ANG | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.52e-01 | -0.1462 |
283 | ANG | HTA11_546_2000001011 | Human | Colorectum | AD | 1.43e-09 | 3.74e-01 | -0.0842 |
283 | ANG | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.08e-04 | 1.98e-01 | -0.0179 |
283 | ANG | HTA11_866_3004761011 | Human | Colorectum | AD | 3.29e-15 | 2.98e-01 | 0.096 |
283 | ANG | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.15e-01 | 0.0446 |
283 | ANG | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.19e-02 | 2.05e-01 | 0.0528 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004341012 | Prostate | Tumor | positive regulation of MAPK cascade | 110/3246 | 480/18723 | 9.41e-04 | 6.18e-03 | 110 |
GO:001820913 | Prostate | Tumor | peptidyl-serine modification | 81/3246 | 338/18723 | 1.11e-03 | 7.14e-03 | 81 |
GO:00431161 | Prostate | Tumor | negative regulation of vascular permeability | 9/3246 | 18/18723 | 1.51e-03 | 9.27e-03 | 9 |
GO:003300211 | Prostate | Tumor | muscle cell proliferation | 61/3246 | 248/18723 | 2.26e-03 | 1.28e-02 | 61 |
GO:000189416 | Prostate | Tumor | tissue homeostasis | 65/3246 | 268/18723 | 2.39e-03 | 1.35e-02 | 65 |
GO:003162313 | Prostate | Tumor | receptor internalization | 32/3246 | 113/18723 | 2.51e-03 | 1.40e-02 | 32 |
GO:006024915 | Prostate | Tumor | anatomical structure homeostasis | 74/3246 | 314/18723 | 2.82e-03 | 1.54e-02 | 74 |
GO:004352315 | Prostate | Tumor | regulation of neuron apoptotic process | 53/3246 | 212/18723 | 2.92e-03 | 1.58e-02 | 53 |
GO:004825914 | Prostate | Tumor | regulation of receptor-mediated endocytosis | 31/3246 | 110/18723 | 3.15e-03 | 1.65e-02 | 31 |
GO:003238711 | Prostate | Tumor | negative regulation of intracellular transport | 19/3246 | 58/18723 | 3.18e-03 | 1.66e-02 | 19 |
GO:004353612 | Prostate | Tumor | positive regulation of blood vessel endothelial cell migration | 23/3246 | 76/18723 | 3.92e-03 | 1.99e-02 | 23 |
GO:0043114 | Prostate | Tumor | regulation of vascular permeability | 16/3246 | 47/18723 | 4.27e-03 | 2.13e-02 | 16 |
GO:190495011 | Prostate | Tumor | negative regulation of establishment of protein localization | 35/3246 | 131/18723 | 4.63e-03 | 2.28e-02 | 35 |
GO:007037113 | Prostate | Tumor | ERK1 and ERK2 cascade | 76/3246 | 330/18723 | 4.66e-03 | 2.29e-02 | 76 |
GO:005122411 | Prostate | Tumor | negative regulation of protein transport | 34/3246 | 127/18723 | 5.03e-03 | 2.45e-02 | 34 |
GO:190121514 | Prostate | Tumor | negative regulation of neuron death | 51/3246 | 208/18723 | 5.24e-03 | 2.52e-02 | 51 |
GO:007200613 | Prostate | Tumor | nephron development | 37/3246 | 142/18723 | 5.73e-03 | 2.67e-02 | 37 |
GO:004353412 | Prostate | Tumor | blood vessel endothelial cell migration | 44/3246 | 176/18723 | 6.27e-03 | 2.89e-02 | 44 |
GO:004427211 | Prostate | Tumor | sulfur compound biosynthetic process | 38/3246 | 148/18723 | 6.69e-03 | 3.06e-02 | 38 |
GO:00140651 | Prostate | Tumor | phosphatidylinositol 3-kinase signaling | 37/3246 | 144/18723 | 7.29e-03 | 3.25e-02 | 37 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050141 | Colorectum | AD | Amyotrophic lateral sclerosis | 164/2092 | 364/8465 | 4.28e-18 | 1.27e-16 | 8.09e-17 | 164 |
hsa050142 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa050143 | Colorectum | SER | Amyotrophic lateral sclerosis | 138/1580 | 364/8465 | 9.89e-19 | 2.99e-17 | 2.17e-17 | 138 |
hsa050144 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050145 | Colorectum | MSS | Amyotrophic lateral sclerosis | 156/1875 | 364/8465 | 1.43e-19 | 4.62e-18 | 2.83e-18 | 156 |
hsa050146 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa050147 | Colorectum | MSI-H | Amyotrophic lateral sclerosis | 95/797 | 364/8465 | 2.31e-21 | 1.50e-19 | 1.26e-19 | 95 |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501414 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0501415 | Liver | Cirrhotic | Amyotrophic lateral sclerosis | 187/2530 | 364/8465 | 1.56e-18 | 6.50e-17 | 4.01e-17 | 187 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANG | SNV | Missense_Mutation | c.265C>G | p.His89Asp | p.H89D | P03950 | protein_coding | deleterious(0) | benign(0.003) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ANG | SNV | Missense_Mutation | rs141398857 | c.356N>A | p.Arg119Gln | p.R119Q | P03950 | protein_coding | deleterious(0.01) | possibly_damaging(0.463) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANG | SNV | Missense_Mutation | rs146485834 | c.224G>A | p.Arg75His | p.R75H | P03950 | protein_coding | tolerated(0.1) | benign(0.015) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANG | SNV | Missense_Mutation | novel | c.269N>T | p.Arg90Ile | p.R90I | P03950 | protein_coding | tolerated(0.17) | benign(0.078) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANG | SNV | Missense_Mutation | novel | c.133N>T | p.Arg45Trp | p.R45W | P03950 | protein_coding | tolerated(0.08) | benign(0.139) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ANG | SNV | Missense_Mutation | novel | c.103N>G | p.Thr35Ala | p.T35A | P03950 | protein_coding | tolerated(0.75) | benign(0) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
ANG | SNV | Missense_Mutation | c.19G>A | p.Val7Ile | p.V7I | P03950 | protein_coding | tolerated(0.2) | benign(0.011) | TCGA-BS-A0UM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ANG | SNV | Missense_Mutation | novel | c.323N>T | p.His108Leu | p.H108L | P03950 | protein_coding | tolerated(0.55) | benign(0.012) | TCGA-DD-AAE9-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ANG | SNV | Missense_Mutation | novel | c.302N>T | p.Gln101Leu | p.Q101L | P03950 | protein_coding | deleterious(0.03) | possibly_damaging(0.645) | TCGA-77-8154-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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