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Gene: TRA2B |
Gene summary for TRA2B |
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Gene information | Species | Human | Gene symbol | TRA2B | Gene ID | 6434 |
Gene name | transformer 2 beta homolog | |
Gene Alias | Htra2-beta | |
Cytomap | 3q27.2 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | P62995 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6434 | TRA2B | GSM4909277 | Human | Breast | Precancer | 1.64e-06 | 8.56e-01 | 0.0177 |
6434 | TRA2B | GSM4909280 | Human | Breast | Precancer | 3.50e-04 | 5.93e-01 | 0.0305 |
6434 | TRA2B | GSM4909281 | Human | Breast | IDC | 2.61e-03 | 2.63e-01 | 0.21 |
6434 | TRA2B | GSM4909282 | Human | Breast | IDC | 1.15e-07 | 3.65e-01 | -0.0288 |
6434 | TRA2B | GSM4909285 | Human | Breast | IDC | 6.11e-03 | 8.85e-02 | 0.21 |
6434 | TRA2B | GSM4909286 | Human | Breast | IDC | 6.63e-04 | -2.13e-01 | 0.1081 |
6434 | TRA2B | GSM4909293 | Human | Breast | IDC | 5.99e-20 | 4.55e-01 | 0.1581 |
6434 | TRA2B | GSM4909294 | Human | Breast | IDC | 1.39e-07 | -3.96e-01 | 0.2022 |
6434 | TRA2B | GSM4909296 | Human | Breast | IDC | 7.51e-03 | -2.22e-01 | 0.1524 |
6434 | TRA2B | GSM4909297 | Human | Breast | IDC | 1.56e-12 | -1.90e-01 | 0.1517 |
6434 | TRA2B | GSM4909298 | Human | Breast | IDC | 3.87e-03 | 1.66e-01 | 0.1551 |
6434 | TRA2B | GSM4909299 | Human | Breast | IDC | 3.16e-07 | 3.54e-01 | 0.035 |
6434 | TRA2B | GSM4909302 | Human | Breast | IDC | 1.39e-03 | -3.02e-01 | 0.1545 |
6434 | TRA2B | GSM4909311 | Human | Breast | IDC | 1.11e-23 | -4.35e-01 | 0.1534 |
6434 | TRA2B | GSM4909312 | Human | Breast | IDC | 9.61e-05 | -2.17e-01 | 0.1552 |
6434 | TRA2B | GSM4909315 | Human | Breast | IDC | 1.36e-02 | -3.29e-01 | 0.21 |
6434 | TRA2B | GSM4909316 | Human | Breast | IDC | 2.71e-02 | -3.53e-01 | 0.21 |
6434 | TRA2B | GSM4909319 | Human | Breast | IDC | 1.13e-30 | -3.68e-01 | 0.1563 |
6434 | TRA2B | GSM4909321 | Human | Breast | IDC | 5.56e-08 | -6.23e-02 | 0.1559 |
6434 | TRA2B | brca2 | Human | Breast | Precancer | 7.25e-05 | 6.56e-03 | -0.024 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002198722 | Thyroid | ATC | cerebral cortex development | 55/6293 | 114/18723 | 8.32e-04 | 4.57e-03 | 55 |
GO:004802633 | Thyroid | ATC | positive regulation of mRNA splicing, via spliceosome | 15/6293 | 22/18723 | 9.63e-04 | 5.13e-03 | 15 |
GO:000974632 | Thyroid | ATC | response to hexose | 95/6293 | 219/18723 | 1.56e-03 | 7.92e-03 | 95 |
GO:000974932 | Thyroid | ATC | response to glucose | 92/6293 | 212/18723 | 1.80e-03 | 8.87e-03 | 92 |
GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
GO:003350024 | Thyroid | ATC | carbohydrate homeostasis | 109/6293 | 259/18723 | 2.56e-03 | 1.18e-02 | 109 |
GO:007132224 | Thyroid | ATC | cellular response to carbohydrate stimulus | 72/6293 | 163/18723 | 3.12e-03 | 1.41e-02 | 72 |
GO:004259325 | Thyroid | ATC | glucose homeostasis | 108/6293 | 258/18723 | 3.27e-03 | 1.47e-02 | 108 |
GO:000167825 | Thyroid | ATC | cellular glucose homeostasis | 75/6293 | 172/18723 | 3.89e-03 | 1.69e-02 | 75 |
GO:007133324 | Thyroid | ATC | cellular response to glucose stimulus | 66/6293 | 151/18723 | 6.05e-03 | 2.43e-02 | 66 |
GO:007133124 | Thyroid | ATC | cellular response to hexose stimulus | 66/6293 | 153/18723 | 8.61e-03 | 3.28e-02 | 66 |
GO:007132624 | Thyroid | ATC | cellular response to monosaccharide stimulus | 66/6293 | 154/18723 | 1.02e-02 | 3.71e-02 | 66 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030408 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304013 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304023 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304033 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304043 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa0304053 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa04936 | Liver | Cirrhotic | Alcoholic liver disease | 60/2530 | 142/8465 | 1.07e-03 | 5.85e-03 | 3.61e-03 | 60 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa049361 | Liver | Cirrhotic | Alcoholic liver disease | 60/2530 | 142/8465 | 1.07e-03 | 5.85e-03 | 3.61e-03 | 60 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRA2B | SNV | Missense_Mutation | c.62G>A | p.Gly21Glu | p.G21E | P62995 | protein_coding | deleterious_low_confidence(0.04) | benign(0.134) | TCGA-A2-A0YM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRA2B | SNV | Missense_Mutation | rs758758553 | c.221N>A | p.Arg74His | p.R74H | P62995 | protein_coding | tolerated_low_confidence(0.27) | benign(0.375) | TCGA-AR-A254-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
TRA2B | SNV | Missense_Mutation | c.544A>T | p.Met182Leu | p.M182L | P62995 | protein_coding | tolerated(0.16) | benign(0.079) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRA2B | SNV | Missense_Mutation | c.186A>C | p.Arg62Ser | p.R62S | P62995 | protein_coding | tolerated_low_confidence(0.2) | benign(0.012) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRA2B | SNV | Missense_Mutation | novel | c.734N>C | p.Gly245Ala | p.G245A | P62995 | protein_coding | tolerated_low_confidence(0.07) | possibly_damaging(0.794) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TRA2B | deletion | Frame_Shift_Del | novel | c.821delN | p.Tyr274SerfsTer18 | p.Y274Sfs*18 | P62995 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TRA2B | SNV | Missense_Mutation | novel | c.772N>G | p.Gln258Glu | p.Q258E | P62995 | protein_coding | tolerated_low_confidence(0.22) | benign(0.042) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRA2B | SNV | Missense_Mutation | c.275N>A | p.Arg92Lys | p.R92K | P62995 | protein_coding | deleterious(0.04) | possibly_damaging(0.745) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TRA2B | SNV | Missense_Mutation | novel | c.650N>T | p.Arg217Leu | p.R217L | P62995 | protein_coding | deleterious(0.01) | benign(0.003) | TCGA-JX-A5QV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRA2B | SNV | Missense_Mutation | novel | c.296N>G | p.Ser99Cys | p.S99C | P62995 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-MY-A5BF-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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